Chemotherapy Flashcards
Includes _______ drugs and hormone _____
- Anticancer
- therapy
Hormone therapy:
- Some tumors require hormones for growth
- Some tumors are inhibited by hormones
- Corticosteroids
Some tumors require hormones for growth:
Hormone dependent and will regress temporarily if deprived of their hormone
- prostate tumors require testosterone and are inhibited by the removal of the testes or by administration of estrogen (blocking the effect of testosterone)
- Some great cancers can be temporarily controlled
Some tumors are inhibited by hormones
Some great carcinomas in postmenopausal women are inhibited by estrogen
Corticosteroids can inhibit:
Growth of many tumors by inhibiting protein synthesis which suppresses growth and division of tumor cells
Side effects: Hormone therapy
- Hot flashes
- sweating
- Impotence
- Decreased libido
- Nausea & vomiting
- Blood dyscrasias: pathological/abnormal elements in blood (with tamoxifen teats advanced breast cancer)
Anticancer drugs
Alkylating agents
Antimetabolites
Antitumor Antibodies
Plant alkaloids
Alkylating agents:
React with DNA and inhibit cell division by biding DNA strands together
Antimetabolites:
resemble essential compounds required for cell growth but cannot be utilized by the cell so the metabolic process is disrupted
Antitumor Antibodies:
Bind with DNA and interfere with DNA-dependent RNA synthesis.
Plant alkaloids:
Disrupt mitosis
Used to (anticancer drugs)
- Induce regression of tumor and its metastasis
- Adjunct to surgery or radiation
- Control residual disease
- Relieve pain
- Relieve other symptoms
Side effects: (Anticancer drugs)
Can cause transient change in normal tissues especially rapidly proliferating cells
- Depress bone marrow
- Irritate GI epithelial cells
- Destroy cells of hair follicles & skin
- pain during administration
- venous sclerosis
- Extravasated
Depress bone marrow:
- Anemia
- Leukopenia
- Thrombocytopenia: abnormally low blood clotting platelets (reduced)
Irritated gastrointestinal epithelial cells:
- Ulceration
- Bleeding
- Vomiting
- Diarrhea