Chemotherapy Flashcards

1
Q

Includes _______ drugs and hormone _____

A
  • Anticancer

- therapy

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2
Q

Hormone therapy:

A
  • Some tumors require hormones for growth
  • Some tumors are inhibited by hormones
  • Corticosteroids
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3
Q

Some tumors require hormones for growth:

A

Hormone dependent and will regress temporarily if deprived of their hormone

  • prostate tumors require testosterone and are inhibited by the removal of the testes or by administration of estrogen (blocking the effect of testosterone)
  • Some great cancers can be temporarily controlled
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4
Q

Some tumors are inhibited by hormones

A

Some great carcinomas in postmenopausal women are inhibited by estrogen

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5
Q

Corticosteroids can inhibit:

A

Growth of many tumors by inhibiting protein synthesis which suppresses growth and division of tumor cells

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6
Q

Side effects: Hormone therapy

A
  • Hot flashes
  • sweating
  • Impotence
  • Decreased libido
  • Nausea & vomiting
  • Blood dyscrasias: pathological/abnormal elements in blood (with tamoxifen teats advanced breast cancer)
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7
Q

Anticancer drugs

A

Alkylating agents
Antimetabolites
Antitumor Antibodies
Plant alkaloids

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8
Q

Alkylating agents:

A

React with DNA and inhibit cell division by biding DNA strands together

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9
Q

Antimetabolites:

A

resemble essential compounds required for cell growth but cannot be utilized by the cell so the metabolic process is disrupted

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10
Q

Antitumor Antibodies:

A

Bind with DNA and interfere with DNA-dependent RNA synthesis.

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11
Q

Plant alkaloids:

A

Disrupt mitosis

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12
Q

Used to (anticancer drugs)

A
  • Induce regression of tumor and its metastasis
  • Adjunct to surgery or radiation
  • Control residual disease
  • Relieve pain
  • Relieve other symptoms
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13
Q

Side effects: (Anticancer drugs)

A

Can cause transient change in normal tissues especially rapidly proliferating cells

  • Depress bone marrow
  • Irritate GI epithelial cells
  • Destroy cells of hair follicles & skin
  • pain during administration
  • venous sclerosis
  • Extravasated
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14
Q

Depress bone marrow:

A
  • Anemia
  • Leukopenia
  • Thrombocytopenia: abnormally low blood clotting platelets (reduced)
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15
Q

Irritated gastrointestinal epithelial cells:

A
  • Ulceration
  • Bleeding
  • Vomiting
  • Diarrhea
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16
Q

Destroy cells of hair follicles and skin:

A
  • Alopecia: hair loss/baldness

- Dermatitis: skin inflammation

17
Q

Pain during administration:

A

just know its a side effects

18
Q

Venous sclerosis:

A

Hardening of tissue

19
Q

If extraverted:

A

(Let/force fluid from vessel) especially with deep cutaneous necrosis