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Cancer Y2 > Chemotherapy > Flashcards

Chemotherapy Flashcards

1
Q

Types of systematic anti cancer therapy

A

Chemo
Targeted therapy
Anti angiogenic
Immunotherapy
Hormonal

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2
Q

How do anti angiogenics treat cancer

A

Inhibit blood supply to tumour

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3
Q

How do immunotherapies treat cancer

A

Stimulate immune system to target cancer

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4
Q

How do hormonal therapies treat cancer

A

Target hormones driving cancer

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5
Q

How does electrochemotherapy increase chemo effects

A

Current makes cells more permeable

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6
Q

What type of cancer treatment is crizotinib

A

Targeted

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7
Q

What type of cancer treatment is bevacizumab

A

Anti angiogenic

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8
Q

What type of cancer treatment is carboplatin

A

Chemo

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9
Q

What type of cancer treatment is tamoxifen

A

Hormonal

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10
Q

What type of cancer treatments are pembrolizumab and atezolizumab

A

Immunotherapy

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11
Q

Which treatment are germ cell cancers often exclusively responsive to

A

Chemo

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12
Q

Curative chemo

A

Get rid of cancer without other interventions

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13
Q

Neo adjuvant chemo

A

Given prior to surgery/radio to improve pt fitness, downstage cancer, and eradicate micro metastases

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14
Q

Adjuvant chemo

A

Chemo Given after surgery/radio to eradicate micro metastasis

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15
Q

Palliative chemo

A

Given to improve cancer symptoms

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16
Q

Administration methods of chemo

A

Topical
SC
IM
Oral
Intra arterial
Intra cavity
Intra the cal
IV

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17
Q

5 types of chemo drugs

A

Alkylating agents
Platinum agents
Antimetabolites
Topoisomerase inhibitors
Tubulin active agents

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18
Q

Alkylating agent MOA

A

Bind to nucleophilic moieties on all molecules, treats cancer by binding to DNA

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19
Q

Alkylating agent drug examples

A

Cyclophosphamide
Ifosfamide
Busulfan

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20
Q

Platinum agent MOA

A

Develop covalent addicts with DNA with kills cells directly and increases indirect cell death during division

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21
Q

Platinum agent drug examples

A

Carboplatin
Cisplatin
Oxaliplatin

22
Q

Antimetabolite MOA

A

Incorporated into DNA/RNA and interfere with synthesis

23
Q

Antimetabolite drug examples

A

Methotrexate
6-mercaptopurine
5-fluorouracil

24
Q

Why are antimetabolites e corporates into DNA and RNA

A

structural analogues of molecules normally incorporated

25
Q

Topoisomerase inhibitor MOA

A

Loss of DNA topological state regulation during replication, transcription, and chromatin remodelling

26
Q

2 types of Topoisomerase inhibitor types

A

Topoisomerase-I inhibitor
Topoisomerase-II inhibitor

27
Q

Topoisomerase inhibitor drug examples

A

Ironotecan T1 inhib
Topotecan T1 inhib
Doxorubicin T2 inhib
Epirubicin T2 inhib

28
Q

2 types of Tubulin active agents

A

Vinca alkaloids
Taxanes

29
Q

Vinca alkaloid Tubulin active agent MOA

A

prevent microtubule assembly mitotic spindle formation preventing mitosis

30
Q

Vinca alkaloid Tubulin active agent drugs examples

A

Vinblastine
Vincristine

31
Q

Taxane Tubulin active agent MOA

A

bind to microtubules preventing disassembly

32
Q

Taxane Tubulin active agent drug examples

A

Paclitaxel
Docetaxel

33
Q

Bleomycin MOA

A

Cytotoxic Antibiotic mixture with Antitumour and antibacterial properties

34
Q

Actinomycin D MOA

A

Cytotoxic antibiotic which inhibits mRNA synthesis

35
Q

L asparaginase MOA

A

depletes asparaginine in blood and extracellular space depriving tumour of amino acids

36
Q

Trabectedin MOA

A

distorts DNA shape interfering with intracellular transcription and DNA repair

37
Q

Cell cycle specific chemotherapy

A

Agents with major activity in a particular cell cycle phase

38
Q

Cell cycle non specific chemo

A

Agents with significant activity in multiple cell cycle phases

39
Q

Are cell cycle specific drugs schedule dependent or dose dependent

A

Schedule dependent
Cell cycle non specific are dose dependent

40
Q

Which cell cycle phases does vinblastine have significant effect in

41
Q

Which cell cycle phase do tubulin active agents have significant effects in

42
Q

Which cell cycle phase do antimetabolites have significant effects in

43
Q

Which cell cycle phase do bleomycin, etoposide, topotecan, and daunorubicin have significant effects in

44
Q

Which drugs are cell cycle non specific

A

Cyclophosphamide
Chlorambucil
Cisplatin
Actinomycin D

45
Q

Chemo general side effects

A

Nausea, vomiting
Mouth ulcers
Metallic taste in mouth
Diarrhoea
Constipation
Fatigue
Bleeding and bruising
Infection risk
Rash, skin and nail changes
Liver, cardiac, lung, and renal function changes
Neuropathy
Tinnitus
Early menopause, loss of libido, infertility
Blood clot
Hair loss
Allergic reaction

46
Q

Which drug causes flagellate erythema

47
Q

What drug causes raspberry urine

A

Doxorubicin

48
Q

What drug causes pulmonary fibrosis

49
Q

What drug causes palmar plantar erythrodysesthesia

A

Capecitabine

50
Q

Which drug causes peri orbital oedema

Cancer Y2 (11 decks)

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