Chemotherapy Flashcards
What are the 3 classifications of Antineoplastic agents?
- Cell cycle non-specific drugs
- Cell cycle specific drugs
- Tissue-specific agents
What are the 2 types of cell cycle non-specific agents?
- Alkylating agents
2. Antineoplastic antibiotics
How do antineoplastic antibiotics work?
cytotoxic antibiotics are toxic to bacterial cells as well as other cells. They prevent reproduction of RNA.
Antineoplastic antibiotics are a cell cycle _____ drug.
non-specific
Doxorubicin is a ______drug
antibiotic-type antineoplastic-cytotoxic antibiotic
Red urine and cardiac toxicity are ADRs of what drug?
Doxorubicin
What are S phase cell cycle specific drugs?
MTX is an antimetabolite
What drugs target the M phase of the cell cycle?
Mitotic poisons - Vincristine and Vinblastine
True/False: Vincristine and Vinblastine can be given SC.
False. They are IV only.
Vincristine and Vinblastine can cause _______ toxicity.
Neurological.
What does MTX treat, as well as cancer?
Rheumatoid Arthritis
MTX targets rapidly ________ cells. Such as ____ ,____ and ____.
proliferating, hair, bone marrow, GI tract.
What is the antidote for MTX?
Leucovorin.
What drug is a folic acid antagoist?
MTX
What are the precautions regarding MTX and conception?
MTX is a folic acid antagonist and also attacks proliferating cells - including the fetus.