chemotherapeutic agents Flashcards
What is a chemotherapeutic agent?
A chemotherapeutic agent is a chemical used for therapeutic reasons, often to treat infections or conditions.
What is the difference between bactericidal and bacteriostatic effects?
Bactericidal kills bacteria, while bacteriostatic stops the growth of bacteria.
What are the modes of administration for antimicrobial agents?
Systemic Administration: Affects larger areas but can cause bacterial resistance.
Local Delivery: Site-specific, concentrated, with less risk of resistance.
What are the advantages of antimicrobial therapy in periodontal treatment?
Reduces subgingival bacteria.
Reduces probing depths.
Enhances clinical attachment levels.
Reduces bleeding.
What are common local delivery agents in periodontal therapy?
Doxycycline Polymer (Atridox®)
Minocycline Hydrochloride (Arestin®)
Chlorhexidine Chip (Perio Chip®)
What must antimicrobial agents do to be effective?
They must reach the infection site and have substantivity to remain effective over time.
How are local delivery agents typically used in periodontal treatment?
They are used alongside scaling and root planing (SRP) and maintenance appointments to enhance treatment outcomes.
What are the contraindications for using local delivery agents?
Pregnancy/Nursing
Allergies to the agent
Noncompliant patients
Pocket depths <5mm
Cost concerns
What is the active ingredient in Doxycycline Polymer (Atridox®)?
The active ingredient is Doxycycline hyclate 10% (50mg).
What is the expected pocket depth reduction with Doxycycline Polymer (Atridox®) when used with SRP?
Pocket depth reduction is approximately 0.47mm.
What is the advantage of Minocycline Hydrochloride (Arestin®)?
Arestin® is bioresorbable and does not require removal, and the pocket depth reduction is approximately 0.49mm when used with SRP.
Post-Op Instructions for Arestin:
Avoid touching or brushing the treated area for 12 hours.
Avoid hard, crunchy, or sticky foods for 1 week.
Postpone flossing or using interdental cleaning devices for 10 days.
What is the CDT Code for crevicular agents used in periodontal disease treatment?
D4381 and D4381A from the Student Access Program
