Chemical Pathways of Drug Metabolism: Termination of Drug Action, Bioactivation of Drugs/ Prodrugs

Question 1

Duration of action and half life are significant __________ properties of a drug

Answer 1

Pharmacokinetic

Question 2

True or false: Atorvastatin (Lipitor) is an inactive compound converted to its active metabolite via CYP3A4

Answer 2

False. Atorvastatin is an active compound that undergoes metabolism to an equipotent active metabolite

Question 3

True or false: Losartan’s active metabolite EXP-3174 is 10-40 more times potent than losartan

Answer 3

True

Question 4

More potent metabolites express (inc/dec) therapeutic effect and (inc/dec) adverse effects

Answer 4

Increased, increased

Question 5

What is the most commonly administered CCB?

Answer 5

Amlodipine

Question 6

What is the structure of CCBs?

Answer 6

1,4-Dihydropyridines

Question 7

How do antibiotics interfere with birth control efficacy?

Answer 7

Antibiotics kill gut microflora, which are necessary to breakdown birth control metabolites necessary for their contraceptive action

Question 8

Which of the following is not an example of a drug metabolism process?
Active -> Active
Active -> Inactive
Active -> Altered active
Inactive -> Inactive
Inactive -> Active

Answer 8

Inactive -> Inactive

Question 9

Enalapril being metabolized to Enalaprilat is an example of which type of drug metabolism?
Active -> Active
Active -> Inactive
Active -> Altered active
Inactive -> Active

Answer 9

Inactive -> Active

Question 10

How does Prilosec interact with Clopidogrel (Plavix)?

Answer 10

Prilosec is a PPI which inhibits CYP2C19, reducing the amount of active metabolite formed from Clopidogrel