????Characteristics of the water-electrolyte and acid-base balance in childhood. Flashcards

1
Q

in chich compartment s fluid higher intracellular or extracellular ?

A

intracellular - 67 percent

extracellular - 
interstitial fluid 26 percent 
blood plasma - 7 percent 
cerebrospinal fluid - less than 1 percent 
=34 percent
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2
Q

what the cations and anions found intracellular

A

cations (+) = POTASSIUM
sodium
mg

balances with

anions (-)
PHOSPHATES
proteins- 
HCO3
chlorin
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3
Q

what are the cations and anions found extracellularly int he plasma ?

A

cations
SODIUM
little bit of potassium , calcium , magnesium

what are the anions
CHLORIDE
hco3
proteins

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4
Q

what are the main ways of water loss ?

A

60 percent through urine

35 percent through perspiration and lungs

5 percent = through stool

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5
Q

what are the causes for dehydration

A

gastroenteritis = vomiting diarrhoea

DKA 
diabestes mellitus 
burns 
psycho states
temperate 
poor oral intake - stomatitis , pharyngitis
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6
Q

what is important when assesing dehydration pediatrics ?

A

degree of dehydration - mild , moderate or sevrere

OSMOLARITY OF BLOOD - isotonic , hypotonic , hypertonic ( hypernatermeic )

the age of the child

how quickly the dehydration developed

concomitant disease

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7
Q

in infants what percentage of water loss relates to the degree of of dehydration

A

mild = 5 percent water loss
in infancy
3% adolescent

moderate = 10 pecrent water loss in infancy
6 percent adolescent

severe 15 percent water loss in infancy
9 percent adolescent

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8
Q

in adolescencewhat percentage of water loss relates to the degree of of dehydration

A

mild = 3 percent of water loss

moderate = 6 percent

severe 9 percent

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9
Q

in infants if there is mild dehydration what are the mild symptoms and signs

A

thirsty
alert
restless

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10
Q

in infants and young what are the moderate signs and symptoms

A

thirsty
restless / lethargic
irritable
drowsy

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11
Q

in infants and young what are the severe signs and symptoms

A
drowsy 
limp 
cold 
sweaty 
cyanotic extremities 
comatose
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12
Q

in older children what are the symptoms

A

mild - thirsty , alert , restless and excitement

moderate - thirsty , alert , irritable

severe - reduced conciseness but still conscious 
cold 
sweaty 
cystic extremities 
wrinkled skin 
muscle cramps
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13
Q

what are the further signs of dehydration in relation to its degree

A

presence of tallest 3 or more of this indicate moderate dehydration

mild = mucous membrane moist
decreased urin output - EARLY INDICATOR

moderate 
orthstatic tachycardia 
weak palpable pulse
orthostatic hypotension 
slightly reduction in skin poor turgor 
fontanel slightly depressed
mucous membranes dry 
respirations deep and may be rapid 
oliguria 
ANTERIOIR FONTANEL SUNKEN
sunken eyes
decrease amount of tears 
marbled perfusion 
3-4 s capillary refill 
INCREASED UREA
decrease in PCO2 levels 
severe - tachycardia 
palpable pulses 
hypotension 
cutaneous perfusion reduced 
skin turgor reduced 
fontanel sunken 
mucous membrane dry 
tears absent 
deep and rapid breathing 
anuria and oliguria
more than 4 sec capillary refill
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14
Q

dehydration has three phases when curing what are they

A

oral rehydration solution

should contain glucose and sodium in a ration not to exceed 2:1

use isotonic solution in the beginning because most electrolyte balances disappear that way

containing 5 percent dextrose in 1/4 normal saline
15mEq/l bicarbonate
25mEq/l potassium chloride

50ml/kg within 4 hours = mild

100ml/kg over 4 hours = moderate

additional 10ml/kg is given for each stool

it relies on the transporters of sodium and glucose in the intestinale

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15
Q

breast feeding should only be allowed when during this oral rehydrtion therapy

A

AFTER IT - breast milk or formula mils should not be delayed for more than 24 hours

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16
Q

what is maintencae therapy of the mild to moderate dehydration through diarrhea ?

A

0-10kg
dehydration is complete - 100ml of ORSL/kg/24 until diarrhea stops or for each diarrhoea stool
hourly rate of 4ml/kg/hr

11-20kg
1000ml + 50ml/kg for each 1kg
40ml/hr

more than 20kg
1500ml + 20mL/kg for each 1 kg
60ml/hr

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17
Q

the volume of ORS ingested should be equal to the volume of ?

A

stool loss through diarrhoea

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18
Q

what are the equation to calculate water deficit and electrolyte deficit

A

water :
dehydration percentage x weight

sodium deficit 
water deficit (l) X 80Meq/L
potassium deficit 
water deficit (l)x 30mEq/L
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19
Q

what is the fluid management for dehydration ?

A

norma saline : 20ml/kg over 20 mins (normal saline contains sodium and chloride in equal amounts )

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20
Q

ho w is the fluid therapy adjusted for polyuria ?

A

measure the urine

electrolytes and replace the urine output for ml/ml based on the urine electrolytes

on 5 percent dextrose in 1/2 normal saline with 20mEq/L potassium chloride 20ml/kg over 20 mins until intravascular volume is restored

the time period is determined based on the sodium concentration of the initial dignsosi

21
Q

in hypernatremic dehydration or polyuria the time for fluid repleshment is adjusted according to the initial sodium conc , describe it

A

145-157 mEq/l (na+) = 24hr

158-170 mEq/L = 48hr

171 -183 mEq/L = 72 hr

184-196 mEq/L = 84hr

22
Q

whee is the source of water

A

intake

metabolic catabolic breakdown

23
Q

infants younger than 6 weeks do not produce what ?

24
Q

in an infant what may indicate dehydration ?

A

sunken fontanel

25
infants ability to dilute and concentrate urine is what ?
limited
26
water balance is regulated by which hormone
ADH released by the pitotory acting on the DCT and collecting ducts
27
what increases the water needs
anything which raises the metabolic needs = such as fever or sepsis diabetes burns shock
28
dehydration is further classified into three types depending on the basis of serum sodium concentration such as ?
isotonic - sodium 130-150 mmol/l hypotonic - na less than 130 hypertonic - na more than 150mmol
29
how can we diagnose dehydration ?
weight loss serum sodium hematocrit rapid glucose test or serum glucose urine specific gravity - elevated early in dehydration - not elevated in young children with sickle cell
30
why do infants suffer with dehydration
renal function is still immature and glomerular filtration reaches adult level at 6 months
31
what are the daily needs in infants
3 months = 150ml/kg 6 months = 120 ml/kg 9 months =110ml/kg 1 year old - 100ml/kg for first 10kg second 10kg = 50ml/kg over 20 = 20ml per kg
32
what are the daily fluid needs in new borns ?
``` more 2500kg 1st day = 60ml/kg 2nd = 80ml/kg 3 = 90 5-7 = 120 after 7 = 130-160 ``` ``` less than 2000 kg 1st day = 60 2nd =80 3rd = 100 4 = 110 5-7 = 130 after 7 = 150 -200 ``` ``` less than 1500 1st day = 7 2nd day = 80 3rd day = 100 4th day = 120 5-7= 130 after 7 days = 150- 200 ``` ``` less than 1000 1st day = 90 2nd = 100 3rd = 110 4th = 120 5-7 days = 130 afte 7 days = 150-200 ```
33
how can we determine the deficit of water ?
difference between the body weight before the disease and admission and percentage of dehydration deficiency in L = BW(kg) x %D / 100
34
relate the type of dehydration to the symptoms in isotonic dehydration - proportionate water and electrolytes ``` thirst vomiting skin elasticity skin pulse arterial pressure heart tones size of the heart ```
thirst - moderate vomiting - possible skin elasticity - reduced - MARBELED if very bad and acrocyanosis skin - DRY cool pulse - DISTINCT arterial pressure - low heart tones - different
35
relate the type of dehydration the symptoms in hypotonic - sodium loss is higher than of water loss ``` thirst vomiting skin elasticity skin pulse arterial pressure heart tones size of the heart ```
``` thirst - None vomiting - yes skin elasticity - very bad skin - MOIST cool pulse - BROKEN AND SOFT- filiform arterial pressure - very low heart tones - dEAF ```
36
relate the type of dehydration the symptoms in hypotonic - water loss exceeding that of sodium ``` thirst vomiting skin elasticity skin pulse arterial pressure heart tones size of the heart ```
thirst - strong vomiting skin elasticity - slightly reduced skin - DRY and WARM pulse - FAST arterial pressure - Normal to slightly low heart tones - CLEAR
37
what causes isotonic dehydration
vomiting and diarrhea = gastroenteritis
38
how to describe the water electrolyte in schwartz batter syndrome or syndrome inappropriate adh have ?
euvolumic ( extracellular fluid volume is normal) hyposmolar (low solutes ) hyponatremia (low sodium conc in blood) - high sodium loss in urine THERE IS MILD EDEMA
39
schwartz batter syndrome or syndrome inappropriate adh is caused by ?
lung cell carcinoma - releasing ADH
40
how to describe the water electrolyte balance in diabetes inspidus
hypernatremia (high sodium in blood) - low sodium in urine hyperdiuresis
41
how can we treat hyponatremia ?
infusion of 3 percent NaCl for 1ml/ kg / 20-30min serum level of sodium would increase with 1 mmol/l objective of 135mmol/l
42
how do we calculate sodium deficiency ?
(130- serum na concentration) x0.6 x TT kg
43
what causes hypernatremia ?
1) normal hydration and mild hypervolumia = hypothalamic hypodipisa = iatrogenic hyperaldosteronism =cushing syndrome ``` with dehydration = diabetes insipidus , DM, diuretic hypertensive dehydration burns , sweating , alcohol and diuretics fever less water intake drink sea water for survival ``` children - feeding milk hyperosmolar without giving enough water
44
which type of dehydration is underestimated ?
hypernateremic dehydration - because water moves from ICF to ECFA and preserve blood volume
45
what causes hyponateremic dehydration ?
mucovisidosis - cutaneous salt loss | renal insuffienceny - salt loss
46
hyponateremic dehydration leads to affects which bodily system the most ?
cardiovascular - low blood pressure , tachycardia then nervous system
47
when there is hyponatremic dehydration why is it important to increase the sodium levels slowly
Central pontine myelinolysis - pulls water from brain cells
48
hypernateremic dehydration leads to affects which bodily system the most ?
CNS - delirium , hypersensitivity , seizures , agitation, HYPERREFLEXIA
49
why does correction of hypernatermia have to be slow
when there is hypernatermic dehydration state - the brain cells make idiogenic osmoses to Procters the brain cells from shrinking with the slow correction to isotonic sates these osmoses tend to dissipate fast correction leads to cerebral edema - seiners , brain herniation