Chapter 9 - Pharmaceutical analysis

Question 1

Target

Answer 1

A protein (receptor) related to a disease state.

Question 2

Hit or lead

Answer 2

A compound that binds to the target and possibly mitigates the disease.

Question 3

Drug candidate

Answer 3

A lead with optimized structure motifs to be developed as a new drug.

Question 4

NCE

Answer 4

New chemical entity

Question 5

CTM

Answer 5

Clinical trial materials

Question 6

NDA

Answer 6

New drug application

Question 7

GLP

Answer 7

Good lab practice

Question 8

GMP

Answer 8

Good manufacturing practice

Question 9

CMC

Answer 9

Chemistry, manufacturing, and controls

Question 10

DMPK

Answer 10

Drug metabolism and pharmacokinetics

Question 11

A process of ____ ⇒ ____ ⇒ ____ ⇒ ____ is commonly used for solid dosage forms.

Answer 11

grind, extract, dilute, filter

Question 12

In RPC, all components can be washed out with a strong mobile phase because of

Answer 12

the weak hydrophobic interactions in RPC.

Question 13

Diastereomers can be separated by ___________

Answer 13

achiral RPC.

Question 14

Enantiomers can only be separated by

Answer 14

chiral HPLC.