Chapter 9 - Glycolysis Flashcards
Glycolysis
Catabolic pathway of glucose oxidation to pyruvate
Glucose
C6H12O6
O-glycosidic Bond
Covalent bond links monosaccharides together through O
Pyruvate Aerobic
ATP production through the citric acid cycle and ETC
Pyruvate Anaerobic
Lactate production, ethanol production
Anaerobic 2
C6H12O6 + 2NAD + 2ADP + 2Pi >< 2Pyruvate + 2NADH + 2H + 2ATP + 2H2O
Step 1
Phosphorylation of glucose by hexokinase/glucokinase
Step 2
Isomerization of glucose-6TP to fructose-6-P by phosphoglucoisomerase
Step 3
Phosphorylation of fructose-6-P to fructose-1,6-BP by phosphofructokinase
Step 4
Cleavage of fructose-1,6-BP into glyceraldehyde-3-P/dihydroxyacetone by aldolase
Step 5
Isomerization of dihydroxyacetone-P to glyceraldehyde-3-P by triose phosphate isomerase
Step 6
Oxidation/phosphorylation of glyceraldehyde-3-P to form 1,3-bisphosphoglycerate by glyceraldehyde-3-P dehydrogenase
Step 7
Substrate-level phosphorylation to generate ATP in conversion of 1,3-bisphosphoglycerate to 3-phosphoglycerate by phosphoglycerate kinase
Step 8
Phosphoryl shift in 3-phosphoglycerate to form 2-phosphoglycerate by phosphoglycerate mutase
Step 9
Dehydration of 2-phosphoglycerate to form phosphoenolpyruvate by enolase
Step 10
Substrate-level phosphorylation to generate ATP in conversion of phosphoenolpyruvate to pyruvate by pyruvate kinase
Regulation
Based on the supply-demand of glycolytic intermediates