Chapter 9:: Cutaneous Vasculature Flashcards
What causes tethering and rolling of leukocytes?
Selectins
In, ___________, numbers of MECA-79-positive vessels were found to correlate with survival.
Squamous Cell Carcinoma
Which skin vascular has a composition of paired arterioles and venues that form an interconnected network of vessels coursing on a plane parallel to and just beneath the epidermal surface?
Super Vascular Plexus (SVP)
What cell primarily exits the blood stream through post capillary venules?
Leukocytes
What is a one-cell-thick layer of epithelium-like mesenchymal cells?
Endothelium
What chronic skin disease has an enlarged blood microcirculatory bed within the papillary dermis?
Lichen Rubber Planus
Which skin vascular is parallel to the SVP?
Deep Vascular Plexus
What contains proteins of the coagulation system that produces fibrin gels as well as platelet that can form a primary hemostatic plug?
Blood Plasma
What is a source of thermal information and the executive organ for thermal homeostasis?
The Skin
What part of the skin senses temperature?
Primary Somatosensory Afferent Nerves
How does the skin conserve heat?
Constriction of Cutaneous Vessels
What is the skin’s normal blood flow?
250 to 300 mL/min.
What contribute to thermoregulation through shunts from the arterial directly into the venous beds, thereby bypassing capillary loops, the thermosensitivity of the hand being significantly greater than that of soles?
Glabrous Skin
What is induced during rapid tutor growth without adequate blood supply?
Hypoxia
What is being secreted when hypoxia stimulates tumor cells and macrophages?
TGF-β, PDGF, and CXCL2
What are the proteins that induce proinflammatory changes in Ecstatics that typically do not distinguish among different leukocyte types?
Tumor Necrosis Factor Alpha and Interleukin 1
Stem cells and endothelial progenitor cells have been identified in vessel walls as __________.
Resident Cells
What do call the embryotic tissue from which blood vessels arise?
Angioblasts
What do you call the process where Mesenchymal cells are recruited into the vessel wall, where they subsequently differentiate into SMCs and PCs?
Vascular Remodeling
What do you call this disease that is caused by mutations affecting the encoding SCN9A gene that leads to channelopathies?
Erythromelalgia
The blood also contains a population of circulating ________, characterised as _____________ that function to seek out the presence of microbial antigens to which a prior immune response has been made.
Effector memory T cells
These are also known as intracellular storage granules.
Weibel- Palade bodies
What do you call a skin condition where Ecstatics express high levels of E- and P- selection and moderate amounts of VCAM-1 and ICAM-1?
Acute dermatitis
These family of cells are prominently stored in cytoplasms of a variety of cells and are released when cells are injured, acting as ‘wound hormones’ to stimulate local angiogenesis and connective tissue growth of adults.
Fibroblast growth factor 1 and 2
Enumerate the three kinds of anastomosing connections formed by veins of the dermis.
large anastomoses, small anastomoses, very small anastomoses
