Chapter 10::The Immunological Structure of the Skin Flashcards
What type of white blood cells contain histamine-filled granules and also a rich source of cytokines such as interleukin -4 and -13?
Basohphils
What cell resembles basophils and also plays an important role in allergic tissue inflammation?
Mast Cells
These are by far the largest, and probably the most important, lymphocyte population within NHS.
T Lymphocytes
Cells derived from bone marrow?
Dendric Cells
What are the cells of the cutaneous adaptive response needed for the elicitation and expression of adaptive immunity?
Dendric APC and T Lymphocytes
A prototype of a Th17-driven disease.
Psoriasis
A skin disease that has a strong Th2/Th22 signature.
Atopic dermatitis
Term called for the dual role of skin its ability to separate the host’s structural constituents from the environment, and at the same time, allowing the communication between the inside and and the outside world.
Skin barrier functions
The skin is devoid of _______.
B lymphocytes
Maintenance of cellular and tissue homeostasis requires…
Prevention of exaggerated responses to innocuous substances and occurrence of host-defence reactions at a subclinical level in the absence of inflammation.
Most skin T cells are localised in the _______ and only 10% in the ________.
Dermis / Epidermis
________ and _________ are heavily involved in the elimination of invading microbes.
Macrophages / Mononuclear phagocytes
_______ play a major role in antiviral defense by the massive production of type I interferons upon activation of TLR7 and TLR9.
pDCs
LCs contain endocytic organelles called __________.
Birbeck granules
What do you call the phenomenon where T-cell response is channeled in the MHC class I presentation pathway.
Cross presentation
