Chapter 6:: Skin Glands: Sebaceous, Eccrine, and Apocrine Glands Flashcards
The periphery of the sebaceous gland is a basal cell layer composed of small, _____, _______, ________.
cuboidal, nucleated, highly mitotic sebocytes
A sebaceous gland associated with a hair follicle is termed a _______.
pilosebaceous unit
The hairs associated with these large glands are often tiny, and the total structure is more specifically termed ______, being a pilosebaceous unit variant, the other two being the ______ and the ______.
sebaceous follicles, terminal hair follicle, vellus hair follicle
The earliest known signal necessary for sebaceous gland development is _____
SOX9
Antagonizing _______signaling constitutes an impor- tant prerequisite for normal sebaceous differentiation in postnatal skin tissue.
Wnt–β-catenin
The sebaceous glands exude lipids by disintegration of entire cells, a process known as _________.
holocrine secretion
Sebaceous glands require ________ stimulation to produce significant quantities of sebum.
androgenic
The weak adrenal androgen, ___________, is probably a significant regulator of sebaceous gland activity through its conversion to testosterone
dehydroepiandros- terone sulfate (DHEAS)
___________ is the most potent pharmacologic inhibitor of sebum secretion.
Isotretinoin
___________ may reduce sebaceous lipid synthesis and as such may be useful in the treatment of acne.
PPAR-α agonists and PPAR-γ antagonists
The average transit time of sebaceous gland cells from formation to discharge, has been calculated as______days in the human gland, with 4 to 7 days in undifferentiated and 14 to 25 in differentiated lipid- producing cells.
The synthesis and discharge of the lipids contained in the sebaceous cells require more than 1 week. The size of sebaceous glands ______________ with age.
7.4
increases
