Chapter 9 Flashcards
Fat soluble vitamins
Vitamin A, D, E, K
Fat soluble vitamins require what for absorption
Bile and dietary fat
Vitamin A function
- Vision
- regulate growth and cellular differentiation
- necessary for maintenance of epithelial tissue
Vitamin A sources
- found preformed
- animal products or supplements or in precursor form from plant foods
Eggs, dairy, liver, fish
Orange, yellow and dark green veggies
Retinoids
The chemical forms of preformed vitamin A: retinol, retinal and Retinoic acid
-liver, fish, egg yolk and milk
Animal products
Carotenoids
Natural pigments synthesized by plants and many micro-organisms. They give yellow and red-orange fruits and veggies their colour.
- a precursor converted to retinoids
- provitamin A
- function as antioxidants
Ex: beta-carotene, provitamin converted into vitamin A
Beta-carotene
A carotenoid that’s has more provitamin A activity than other carotenoids. It also acts as an antioxidant.
Vitamin A digestion steps
- Preformed vitamin A and carotenoids are bound to proteins in food. To be absorbed they must be release from the rite in by pepsin
- In small intestine, released retinol and carotenoids combine with bile acids to form micelles which facilitate diffusion into mucosal cells.
- Preformed vitamin A is absorbed more than carotenoids.
- Once inside mucosal cells, much of Beta-carotene is converted to retinoids.
- Preformed vitamin A and carotenoids absorbed are transported from intestine by chylomicrons to body tissues
Retinol-binding protein
A protein that is necessary to transport vitamin A from the liver to other tissues
Rhodopsin
A light absorbing compound found in the retina of the eye that is composed of the protein Opsin loosely bound to retinal
-rhodopsin helps transform the energy from light into a nerve impulse that is sent to the brain
Night blindness
The inability of the eye to adapt to reduced light, causing poor vision in dim light
-caused by vitamin A deficiency
Keratin
A hard protein that makes up hair and nails
-mucus secreting cells during vitamin A deficiency become keratinized and hard
All _______tissues are affected by a deficiency in vitamin A
Epithelial
Xerophthalmia
A spectrum of eye conditions resulting from vitamin A deficiency that may lead to blindness. An early symptom is night blindness, and as deficiency worsens, lack of muscle leaves the eye dry and vulnerable to cracking and infection
- abnormal jaw bone growth in children
- increased infections
Keratomalacia
Softening and drying and ulceration of the cornea resulting from vitamin A deficiency
Vitamin A and D in gene expression
Have functions that regulate gene expression
- cell differentiation: immature cells change in structure and function to become specialized by changing gene expression (on and off)
- vitamin A helps ensure healthy eyes
- vitamin D promoters strong bones
Unconverted carotenoids circulate in blood and may function as
Antioxidants
Retinol activity equivalents (RAE)
The amount of retinol, B-carotene, alpha-carotene or B-cyrptoxanthin that provides vitamin A activity equal to 1 microgram of retinol
Toxicity of vitamin A symptoms
- acute
- chronic
Nausea, vomiting, headache, dizziness, blurred vision, and lack of muscle coordination
Weight loss, muscle and joint pain, liver damage, vision defects, dry scaling skin
Due to excess supplementation
Hypercarotenemia
A condition in which carotenoids accumulate in the adipose tissue, causing the skin to appear yellow-orange, especially the palms of the hands and the soles of the feet
- not dangerous
- when intake lowers, colour disappears
Caused by excess B-carotene
Vitamin D is produced where
In the skin by exposure to ultraviolet light
- inactive until modified in liver and kidneys
- essential in the diet only hen exposure to sunlight is limited or the body’s ability to synthesize it is reduced (winter)
Natural food sources of vitamin D include
Liver, fatty fish like salmon, cod liver oil and egg yolks. These foods contain cholecalciferol
Cholecalciferol
The chemical name for vitamin D3. It can be formed in the skin of a sinks by the action of sunlight in a form of cholesterol called 7-dehydrocholesterol