Chapter 8: Pulmonology Flashcards

1
Q

Most common cause of congenital stridor

A

Laryngomalacia

large floppy epiglottis or floppy arytenoid cartilages

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2
Q

Tx of Laryngomalacia

A

usually resolves w/ growth over the first 1-3 years

-most only need to be followed

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3
Q

Children who present in first year w/ persistent stridor and or hoarseness most likely have?

A

Vocal Cord paralysis or laryngeal papillomatosis

-most only need to be followed

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4
Q

Presentation of OSA

A
  • restless sleep with frequent position changes
  • irregular snoring
  • daytime somnolence
  • poor growth
  • behavioral problems
  • enuresis
  • poor academic performance
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5
Q

Study of choice for OSA

A

polysomnography

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6
Q

Tx of OSA

A

First: try to normalize airway anatomy by removing enlarged tonsils and/or adenoids (if indicated)
If that doesn’t work: CPAP is indicated

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7
Q

Two major LOWER airway obstructive diseases in childhood

A

1) Asthma
2) Cystic Fibrosis
3) Primary ciliary dyskinesia (rare)
* *most patients with asthma wheeze but not all patients who wheeze have asthma**

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8
Q

Risk Factors for Asthma

A
  • genetic predisposition
  • atopy
  • cigarette smoke exposure
  • living in urban areas in poverty
  • African American race
  • Puerto Rican ethnicity
  • Upper respiratory tract infections w/ certain viruses (rhinovirus, RSV) at critical times in early life
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9
Q

What is cough variant asthma?

A

Relatively uncommon

  • produces a chronic cough that may be triggered by exercise or noted primarily at night during sleep
  • wheezing may or may not be present
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10
Q

Patients w/ persistent asthma should have PFTs how often?

A

at least once a year

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11
Q

What do baseline CXR look like in asthma?

A

Mild hyperinflation and/or increased bronchial markings

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12
Q

Obstructive PFTs =

A

find it

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13
Q

Restrictive PFTs=

A

find it

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14
Q

Mainstays of medical treatment of asthma

A
  • inhaled corticosteroids
  • leukotriene receptor antagonists
  • short acting B2 agonists
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15
Q

What is tx of exercise induced asthma?

A

-use SABA 5-20 minutes before vigorous activity

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16
Q

Most effective treatment for chronic asthma?

A

Inhaled corticosteroid treatment

17
Q

Theophylline

A

has fallen out of favor as a first line treatment option

18
Q

Patients >12 w/ severe allergic asthma that remains poorly controlled with use of inhaled corticosteroids and leukotriene receptor antagonists and LABS may benefit from treatment w/?

A

-Omalizumab an injectable monoclonal antibody directed against IgE
(expensive; must be given q2-4 wks)

19
Q

Other tx for severe obstruction

A
  • Ipratropium (anticholinergic)
  • SubQ epinephrine
  • Terbutaline
20
Q

Factors that increase risk of death from asthma

A
  • noncompliance
  • poor recognition of symptoms
  • delay in treatment
  • history of intubation
  • AA race
  • steroid dependence
21
Q

Pathogenesis of Cystic Fibrosis

A
  • autosomal recessively inherited multi system disease characterized by disordered exocrine gland function
  • *most common in caucasians 1/3500**
  • average life expectancy is mid to late 30s
22
Q

Nasal polyps

A

should prompt further testing for CF

23
Q

What bugs usually colonize patients w/ CF?

A

Early childhood = s. aureus and h. influx
Later = p. aeruginosa (90% acquire and it is rarely eradicated)
Particularly ominous = burkholderia cepacia (accelerated pulmonary deterioration and early death)

24
Q

Most common manifestation of untreated CF in infants and children

A

failure to thrive

25
Q

Meconium ileus is pathognomonic for

A
Cystic fibrosis
(neonatal intestinal obstruction in the absence of anatomic abnormalities)
26
Q

Classic diagnostic findings of CF

A
  • elevated sweat chloride concnetration
  • pancreatic insufficiency
  • chronic pulmonary disease
27
Q

Initial diagnostic study of choice

A

-sweat chloride test

level >60 is is generally considered abnormal

28
Q

Tx of CF

A

1) most fundamental = maintain effective airway clearance
-chest PT, vigorous exercise, frequent couging
-Recominbinant human deoxyribonuclease admin via neb breaks down thick complexes
-Alternate months of inhaled tobramycin maybe indicated for patient infected w/ Pseudomonas
(frequently bacterial infections have to be treated w/ IV abx)
2) Maintain Near normal growth
-Pancreatic enzyme replacement
-fat soluble vitamin replacement
-high calorie/high protein diets
(maintenance above 25th%ile = best prognosis)
3) may develop insulin deficiency

29
Q

Complications of CF

A

1) Hemopthysis

2) Spontaneous Pneumothorax

30
Q

Primary ciliary dyskinesia

A

-symptoms are similar to CF or asthma
-Dx is made by demonstration of abnormal ciliary beat under light microscopy or characteristic US changes in samples of ciliated cells obtained from scrapings of the nasal or bronchial epithelium
TX: similar to the pulmonary tx of CF but not same risk of p.aeuroginosa infection

31
Q

Tracheomalacia presentation

A

(common cause of expiratory airway obstruction)
-si-widening of posterior membranous portion of the trachea w/ dynamic collapse during exhalation (severe) or forced expiration (less severe)
HARSH, BRASSY, CROUPY COUGH (often misdiagnosed as having recurrent croup)

32
Q

What makes you think tracheomalacia vs asthma?

A
  • *wheezing of tracheomalacia is made worse by bronchodilator**
  • often misdiagnosed as severe asthma
33
Q

Tx of tracheomalacia

A

most require no intervention

-there are surgical procedures to help some children

34
Q

List some examples of restrictive lung disease

A
  • pectus excavatum
  • pectus carinatum
  • severe scoliosis
  • marked obesity
  • any lesion that occupies intrathoracic space
  • pulmonary hemosiderosis
35
Q

Symptoms of restrictive lung disease

A
  • exercise intolerance
  • tachypnea
  • eventual dyspnea
36
Q

Define apnea

A

cessation of breathing for longer than 20 seconds or pauses of any duration tha are associated w/ color changes, hypotonia, decreased responsiveness or bradycardia

37
Q

Apnea is: diagnosis or sign?

A

Sign that is potentially dangerous that requires aggressive evaluation to define the underlying cause

38
Q

What is ALTE?

A

Apparent life threatening event

  • this is how apnea may come to medical attention
  • cause is not found in about 50%
  • when no treatable cause is found infant may be placed on a him monitor that senses chest movement, heart rate and sounds alarm when child may be apneic or bradycardic
39
Q

Apnea and SIDS

A

Apnea of infancy does not increase the risk of an infant dying from SIDS.
this may be why home monitors have never been proven to decrease the likelihood of SIDS