Chapter 8: Physical and Chemical Injuries Flashcards
what is associated with pressure, irritation, or sucking trauma, is present in 10% of the population, and is a single white line on the occlusal plane of the buccal mucosa?
linea alba
is linea alba typical unilateral or bilateral?
bilateral
what is the treatment for linea alba?
no biopsy or treatment is necessary
___ is the scientific name for cheek chewing
morsicatio buccarum
what are the scientific names for labial mucosa chewing and tongue chewing?
- morsicatio laborium
- morsicatio linguarum
there is a higher prevalence of morsicatio buccarum in those under ___ or with ___
under stress or with psychologic conditions
morsicatio buccarum is typically found where?
bilaterally on the anterior buccal mucosa
how does morsicatio buccarum appear clinically?
thickened, shredded white areas which may be ulcerated
what is the treatment for morsicatio buccarum?
no treatment is required; not a premalignant condition
___ is the result of acute or chronic trauma that can cause surface ulcerations
traumatic ulcerations
where are the most common oral locations of traumatic ulcerations? what is the injury due to?
- lips, tongue, and buccal mucosa
- injured from dentition
___ appears as areas of erythema surrounding a central removable, yellow fibrinopurulent membrane
traumatic ulcerations
___ can develop immediately adjacent to an oral traumatic ulceration
a rolled white border of hyperkeratosis
the unique form of chronic traumatic ulceration is termed ___ or ___
eosinophilic ulceration or TUGSE (traumatic ulcerative granuloma with stromal eosinophilia)
describe TUGSE and its treatment
- traumatic ulcerative granuloma with stromal eosinophilia
- exhibits a deep pseudoinvasive inflammatory process and is slow to resolve
- incisional biopsy is usually curative
___ are chronic ulcerations found under the tongue in infants due to trauma from nursing
riga-fede disease (a form of traumatic ulcerations)
what is the treatment for traumatic ulcerations?
- remove source of injury if possible
- medications for pain releif - topical analgesics
- biopsy is warranted in cases that do not resolve after 2-4 weeks
5% of all burn admissions to hospitals are from what?
electrical burns to the oral cavity
what are the two types of electrical burns?
contact and arc
what is required for contact burns?
a good ground and must involve electrical current passing through the body from the point of contact to the ground site
what can electric current cause?
cardiopulmonary arrest and it can be fatal
most electrical burns affecting the oral cavity are what type?
arc
in arc electrical burns of the oral cavity, ___ acts as a conducting medium and an electrical arc flows between the electrical source and the mouth
saliva
most cases of oral electrical burns are a result of what?
chewing on the female end of an extension cord or biting a live wire
most electrical burns occur in what age patient? what area is affected?
kids younger than 5 and affect the lip
what is the clinical presentation of oral electrical burns?
- appears as a painless, charred, yellow area that doesn’t bleed
- edema develops within a few hours
- on the 4th day, the area becomes necrotic and begins to slough (may bleed profusely)
most thermal burns of the oral cavity arise from what?
the ingestion of hot foods or beverages
describe the location and clinical appearance of thermal burns
- typically appear on the palate or posterior buccal mucosa as zones of erythema and ulceration
some patients hold medications within their mouths rather than swallow them, which can be caustic. what type of injury does this describe?
chemical injury
what are common medications that can cause chemical injuries in the oral cavity?
- aspirin
- bisphosphonates
- two psychoactive drugs - chlorpromazine and promazine
other than medications, what are some other things that cause mucosal necrosis (chemical injury) by patient or dentist misuse?
- tooth-whitening products
- hydrogen peroxide
- phenol
- silver nitrate
- certain endodontic materials
- cotton roll
what tissues are targeted in noninfectious oral complications or antineoplastic therapy (aka anticancer treatment)?
tissues with rapid turnover, like the oral epithelium
how many people a year suffer acute or chronic oral side effects from anticancer treatment?
half a million people
___% of patients receiving head and neck radiation have oral ramifications
100%
___% of patients receiving BMT have oral complications
75%
what are the two predominant problems with anticancer therapy?
mucositis and hemorrhage
hemorrhage associated with anticancer treatments is secondary to ___. what are the most common presentations of hemorrhage?
- secondary to thrombocytopenia (from bone marrow suppression)
- oral petechiae and ecchymosis secondary to minor trauma are the most common presentations
how does mucositis that results from anticancer therapy present clinically?
- white discoloration from a lack of sufficient desquamation of keratin
- soon follows by a loss of keratin and replacement by atrophic mucosa
- areas of ulceration develop
what are 5 main complications of anticancer therapy other than hemorrhage and mucositis?
- xerostomia
- loss of taste
- osteoradionecrosis
- trismus
- developmental abnormalities
describe xerostomia that results from anticancer treatment
- salivary glands are very sensitive to radiation
- increase in caries risk
describe loss of taste that results from anticancer treatment
- loss of all four tastes (hypogeusia) develops, but taste returns in about 4 months
- some patients have a permanent altered taste (dysgeusia)
osteoradionecrosis associated with anticancer treatment occurs in about ___% of people receiving head and neck radiation
5%
the risk of osteoradionecrosis associated with anticancer treatment increases dramatically if what procedure is performed and during what time frame?
local surgical procedure is performed within 3 weeks of therapy or within 1 year after therapy
most cases of osteoradionecrosis associated with anticancer treatment are secondary to ___
local trauma
___ is the main associated factor for osteoradionecrosis associated with anticancer treatment
radiation dose
before therapy, what should be eliminated to avoid cases of osteoradionecrosis associated with anticancer treatment?
all foci of infection should be eliminated
what is BRONJ?
bisphosphonate-related osteonecrosis of the jaw
what are bisphosphonates used for?
- inhibit osteoclasts
- possibly interfere with angiogenesis
- slow osseous involvement of cancer
- treat paget’s disease
- reverse osteoporosis
which generation bisphosphonates have a low potency and are readily metabolized?
first generation
second generation bisphosphonates are more potent than first generation, and are termed ___ due to the addition of a nitrogen side chain
aminobisphophonates
___ generation bisphosphonates are incorporated into the skeleton and have a half-life of 10 years; what location is the incorporation of the medication the highest?
- second
- the incorporation of the medication is highest in areas of active remodeling, such as the jaws
there is a strong association of ___ with aminobisphosphonates
gnathic osteonecrosis
95% of BRONJ occurs in patients who have received ___ for cancer. 85% of these patients had what type of cancer?
- IV formulations for cancer
- multiple myeloma
what is the prevalence of osteonecrosis in pateints taking IV bisphosphonates? what bout patients taking oral bisphosphonates?
- 6-8%
- 1:100,000
60% of BRONJ occurs after ___, ad the remaining 40% occur ___. what fraction are asymptomatic?
- dental procedures
- spontaneously
- 1/3
what is the treatment for BRONJ?
- formulation of the drug
- extend of disease
- duration of drug use
should routine dental therapy be modified for patients with BRONJ?
no