Chapter 8 Flashcards
Glycolysis
Glucose crosses the cell membrane and broken down into pyruvic acid molecules -
ATP
Adenosine TriPhosphate - energy source required by cells to release more energy and needed for cells to function
What are the by-products of aerobic metabolism?
heat
carbon dioxide
water
What are the by-products of anaerobic metabolism?
lactic acid and small amounts of ATP -
lack of oxygen doesn’t allow pyruvic acid to continue the process of metabolism inside mitochondria of the cell and is converted into lactic acid
What happens when the sodium/potassium pump fails?
Sodium collects inside the cell, water follows sodium, swells and eventually will rupture and die
What is needed for adequate perfusion?
ambient air patent airways ventilation ventilation/perfusion ratio oxygen and carbon dioxide transport blood volume pump function of heart systemic vascular resistance microcirculation blood pressure
What is considered ambient air?
78% nitrogen, 21% oxygen, 1 % argon, .03% Carbon dioxide
What concentration of oxygen must be available?
21%
What may cause cellular hypoxia?
low amount of oxygen (need at least 21%)
FiO2
fraction of INSPIRED air -on own
.21
FDO2
fraction of DELIVERED air - with support or device - .95-.98 in non breather mask
What would happen if patient was breathing poisoned air?
may be breathing oxygen but the toxic gases would prevent it from being 21% and not being used effectively and would cause hypoxia
What would happen if a patient has a blocked airway?
lower amount of oxygen would cause hypoxia and eventually death.
Boyle’s Law
volume of gas is inversely proportionate to pressure - increasing size, decreases pressure
increase pressure will decrease volume of gas
decrease in pressure will increase volume of gas
(squeezing a container)
Which is active and passive process of breathing?
inhaling - active - pull out and down to allow in
exhaling - passive - relaxes and pushes air out
Compliance
measure of the ability of the chest wall and lungs to stretch, distend and expand, decrease in compliance makes it more difficult to breath in and out
Minute Ventilation
amount (volume) of air moved in and out of the lungs in one minute
Tidal volume x frequency
What is the average size adult tidal volume?
500 mL
What is the average adult size minute ventilation?
500 mL per breath x 12/min= 6,000mL
What would hyperventilating cause?
lower volume decreases minute ventilation, decreasing air to alveoli, decreasing gas exchange leading to hypoxia.
Alveolar Ventilation
amount of air moved in and out of Alveoli in one minute (dead air space) so (500-150) x 12/min
Dead air space
area of the respiratory tract where air is collected during inhalation however no gas exchange occurs…approx 150 mL