Chapter 7: Muscular System Flashcards
What are the functions of the muscular system?
- Movement
- Maintenance of posture
- Respiration
- Production of body heat
- Communication
- Constriction of organs and vessels
- Contraction of heart
What are the general properties of muscle tissues?
- Contractility
- Excitability
- Extensibility
- Elasticity
Skeletal muscle - causes attached structures to move
Smooth muscle - increase pressure inside hollow organs
Cardiac muscle - increase pressure inside the heart
Contractility
Opposing contraction cause muscle to _______
Lengthen
Ability of muscle to shorten forcefully
Contractility
Capacity of muscles to respond to a stimulus
Excitability
Skeletal muscle - stimulus to contract from nerves (controllable)
Smooth and Cardiac muscle - stimulus to contract involuntarily from neural and hormonal signals (spontaneous)
Excitability
Ability to stretch beyond normal resting length and still be able to contract
Extensibility
Ability of muscles to recoil to its original resting length
Elasticity
what are the 3 types of muscle?
- Skeletal muscle
- Smooth muscle
- Cardiac muscle
- attached to bones
- long, cylindrical
- multiple, peripherally located nucleus
- no cell-to-cell attachments
- has striations
- rhythmic
- voluntary and involuntary (reflexes)
- body movements
Skeletal muscle
- walls of hollow organs, blood vessels, and glands
- spindle shaped
- single, centrally located nucleus
- gap junctions
- doesn’t have striations
- autorhythmic (some)
- involuntary
- moving food through the digestive tract, empties urinary bladder, regulates blood vessel diameter, contracts many gland ducts
Smooth muscle
- heart
- branche, cylindrical
- single, centrally located nucleus
- intercolated disks
- has striations
- autorhythmic
- involuntary
- pumping blood
Cardiac muscle
Skeletal muscle is also called?
Striated muscle
What are muscle cells also called?
Muscle fibers
what is the skeletal muscle composed of?
Skeletal muscle tissue, nervous tissue, connective tissue, and adipose tissue
What are the 3 layers of connective tissue?
- Epimysium
- Perimysium
- Endomysium
- also called as muscular fascia
- connective tissue sheath surrounding each skeletal muscle
Epimysium
numerous visible bundles of muscle fibers that subdivides a whole muscle
Fascicles
- loose connective tissue serving as a passageway for blood vessels and nerves that supply fascicles
- separates muscle fascicle from each other
Perimysium
- passageway for blood vessels and nerves that supply each and separate muscle fiber
- separate each muscle fiber within each fascicles
Endomysium
- enormous cells that has several hundreds of nuclei under the cell membrane
Most: 1mm to 4cm in length
Some: 30cm to 1ft in length
Muscle fiber
what are the 3 muscle fiber components that respond and transmit electrical signals
- Sarcolemma
- Transverse tubules (T tubules)
- Sarcoplasmic reticulum
- cell membrane of muscle fiber
- multiple nuclei of the muscle fiber are located just deep to it
Sarcolemma
- inward folds of the sarcolemma
- carry electrical impulses into the center of the muscle fiber
Transverse tubules or T tubules
- stores high levels of calcium
- its release of calcium is the “switch” for muscle contraction
Sarcoplasmic reticulum
the enlarged portions of the sarcoplasmic reticulum is called?
Terminal cisternae
Cytoplasm of a musle fiber
Sarcoplasm
What are the 2 main structures of muscle fibers?
- Myofibrils
- Myofilaments
- bundles of protein filaments
- interact to shorten the muscle fiber during contraction
- long thread-like structures that extends the length of muscle fibers
Myofibrils
What are the 2 types of myofilament?
- Actin
- Myosin
- thin filaments
- attachment site for the myosin myofilament
Actin myofilaments
2 components of actin myofilaments which dictates when the skeletal muscle will contract?
- Tropomyosin
- Troponin
- covers the active attachment sites
- long, fibrous protein lying along the groove of actin strand
Tropomyosin
- consists of 3 subunits
- anchors troponin to actin
- prevents tropomyosin from uncovering the actin myofilament attachment sites in a relaxed muscle
- binds calcium
Troponin
- structural and functional units of skeletal muscles
- forms myofibrils
- as it shortens, myofibrils shorten too, causing muscle fiber contraction
Sarcomeres
- forms stationary anchor for actin myofilaments
- network of protein fibers forming an attachment site for actin myofilaments
- separate one sarcomere from the next
Z discs
- light-staining bands
- consists only of actin myofilaments
- spans each Z disk and ends at the myosin myofilaments
I band
- dark-staining band
- center of the sarcomere
- contains both actin and myosin myofilaments overlapping
A band
- center of the A band
- contains myosin filaments
H zone
- dark line in the middle of the H zone
- consist of delicate protein filaments that holds myosin filaments in place
M line
- composed of elongated myosin molecules (tiny golf clubs)
- thick myofilaments
Myosin myofilaments
what are myosin filaments consist of?
- Rod portion
- Two myosin heads
Lying parallel to the myosin myofilaments
Rod portion
3 properties of myosin heads
- bind attachment sites on the actin myofilaments to form cross-bridges
- can bend and straighten during contraction
- break down ATP to release energy
- point of contact of motor neuro axon branches with the muscle fiber
- consist of enlarged axon terminals that rest in a portion of sarcolemma
Neuromuscular junction or synapse
axon terminal is called
Presynaptic terminal
Space between the presynaptic terminal and muscle fiber membrane
Synaptic cleft
Muscle cell membrane in the area of the junction
Motor end-plate or postsynaptic membrane
- Each presynaptic terminal has numerous mitochondria and many small spherical sacs called
- Contains the neurotransmitter acetylcholine
synaptic vesicles
- a molecule that allows a neuron to communicate
- can stimulate or inhibit the production of an action potential in the motor-end plate (sarcolemma) by binding it to ligand-gated ion channels
- action potential = release of acetylcholine
Neurotransmitter
- specialized membrane transport proteins
- when opened, it allows ions to cross the cell membrane
ligand-gated ion channels
The parallel attachment of myofilaments in a sarcomere allows them to interact which causes muscle contraction
Sliding filament model
when a muscle contracts, the actin and myosin myofilaments in the sarcomere _______ each other and ______ the sarcomere
Slides past each other, and shorten the sarcomere
Groups of muscle fibers makes up
Muscle fascicle
shortening the sarcomeres causes _________, _________, __________, and _________ to shorten to produce muscle contraction
myofibrils, muscle fibers, muscle fascicles, and muscles
Sarcomeres lengthen during
Muscle relaxation
2 major types of cell membrane channels
Leak ion channels
Gated ion channels
- allows slow leak of ions down their concentration gradient in resting cells
Leak ion channels
- allows slow leak of ions down their concentration gradient in resting cells
Leak ion channels
- most important in stimulated cells
- governs the production of action potentials
Gated ion channels
- electrical charge difference across the cell membrane of an unstimulated cell
- ready to respond at a moment’s notice
inside the cell membrane: negatively charged
outside the cell membrane: positively charged
Resting membrane potential
Exists because:
1. K+ concentration is higher inside than outside
2. Na+ concentration is higher outside than inside
3. more permeable to K+ than Na+
Resting membrane potential
a device used to measure the resting membrane potential
Oscilloscope
- occurs when excitable cell is stimulated
- ion channels in open when cell is stimulated
- depolarization and repolarization
Action potentials
Na+ opens and diffuses = positive
Depolarization
K+ opens and diffuses = negative
- return to the resting value
Repolarization
autoimmune disorder
- antibodies are formed against acetylcholine receptors, reducing the number of receptors in the neuromuscular junction
Myasthenia gravis
After a person dies, Ca+ diffuses causing the body to become very stiff and rigid
Rigor mortis
- acetylcholine is no longer released at the neuromuscular junction
- Ca+ concentration decreases until it diffuses away from the troponin molecules and tropomyosin blocks attachment sites on the actin molecules
Muscle relaxation
Response of a muscle fiber to a single action potential along its motor neuron is called
Muscle twitch
What are the 3 phases of muscle twitch?
- Lag phase
- Contraction phase
- Relaxation phase
gap between the time of stimulus application to the motor neuron and the beginning of contraction
Lag or latent phase
Once the Ca+ is released from the sarcoplasmic reticulum initiates cross-bridge formation and cycling
Contraction phase
concentration of Ca+ decreases slowly due to active transport into the sarcoplasmic reticulum
Relaxation phase
What are the 2 types of muscle contractions?
- Isometric contractions
- Isotonic contractions
- muscle does not shorten
- increases tension in the muscle, but its length stays the same
- bones held in place
Isometric contraction
- muscle shortens
- increases the tension in the muscles and decreases its length
Isotonic contraction
- amount of force in an individual muscle fiber
- increasing the force of contraction of the muscle fibers
Summation
- amount of force in a whole muscle
- increasing the number of muscle fibers contracting
Recruitment
- constitute a single muscle
- the fewer fibers there are, the greater control you have over the muscle
muscle units
wave summation - incomplete tetanus - complete tetanus
Frequency of stimulation
- do not allow complete relaxation between stimuli
incomplete tetanus
- allows no relaxation between stimuli
Complete tetanus
muscles stay contracted too long (constant tension)
Muscle tone