Chapter 7- Fats Flashcards
where is most fat found ? where is a small amount found ?
adipose tissue
small amount found in intramuscular triacylglycerol
how many km can you run on fat stores
13 000 km
why do you want to use fat instead of carbs
because you want to spare glycogen since fatigue is most closely related to glycogen depletion
total fat approximately how many times more than carb stores ?
50 times
what are the three sources of fat for energy ?
adipose tissue and muscle triacylglycerol
with a little bit of plasma TG from VLDL
what are fats stored as ?
TG
what enzyme breaks down fats ?
hormone sensitive lipase
what happens to the fats once they are broken down ?
some are released into the circulation for reuptake, while some are reesterified.
what happens to the glycerol from lipolysis ?
circulates in blood, taken up by liver and used for gluconeogenesis
fats are the primary source of energy in these three states
rest
low to moderate intensity
during recovery between intense activity
what does endurance training do to your fat use ?
improves it
is fat an efficient fuel for muscles ?
no, especially at high intensities
what will determine the principal source of exercise fuel
intensity of exercise
the body has large stores of fat, but seems impossible to use fat as fuel. true or false ?
true
what are the 6 rate-limiting steps of fat oxidation
lipolysis rate removal of FA from fat cells transport of fat in blood transport of FA into muscle cell transport of FA into mitochondria oxidation of FA
in what form is HSL found in adipocytes ?
inactive form converted to active form depending on hormone mediation
what hormones stimulate HSL
epinephrine (not NE)
why does epinephrine stimulate HSL
because it is produced in adrenal medulla, especially during exercise
what is the most important counter regulatory hormone to HSL activation ?
insulin
why can’t the adipocyte reuse the glycerol from lipolysis and therefore most glycerol is released into the plasma ?
because the enzyme glycerokinase which phosphorylates glycerol for reesterification is very low concentrations
what is the percentage of FA that are reesterified at rest ?
70%
during exercise, is reesterification suppressed ?
yes, meaning there is more FA available
why does FA availability increase in exercise ?
because reesterification is suppressed, and also b-receptors stimulate it (catecholamines)
are FA soluble in aqueous environment ?
no