Chapter 7 Flashcards
Cellular Membrana is…
Selectively permeable
Amphipathic
Has both a hydrophilic and hydrophobic regions
Fluid mosaic model
The membrane is a mosaic of protein molecules bobbing in a fluid bilayer of phospholipids
Evolution of Differences in Membrane Lipid Composition
Evolution led to differences in lipid composition (e.g. fish in icy-cold water have a high proportion of unsaturated hydrocarbon tails, enabling the membrane to stay fluid. Bacteria in extreme heats and their composition allows them to stay fluid in that heat. Some organisms can change their composition in places where temperatures vary)
Transmembrane Protein
Span the whole membrane
Integral Proteins
penetrate the bilayer but do not go all the way through
N-terminus
On the extracellular side of a transmembrane protein
C-terminus
On the cytoplasmic side of the transmembrane protein
Transport
Can consist of a transport channel protein or a protein that changes shape to move molecules across the membrane
Enzymatic activity
A protein in the membrane could be an enzyme with the active site exposed to the substances in the adjacent solution
Signal transduction
A membrane protein may have a binding site with a specific shape that fits the shape of a chemical messenger, such as a hormone which may cause the protein to change shape, allowing it to relay a message to the inside of the cell
Cell-cell recognition
some glycol-proteins serve as identification tags that are specifically recognized by membrane proteins of other cells (Shorter bonding)
Intercellular joining
membrane proteins of adjacent cells may hook together in various kinds of auctions (gap junctions or tight junctions) (Longer bonding)
Attachment to cytoskeleton and extracellular matrix (ECM)
Microfilaments or other elements of the cytoskeleton may be noncovalently bound to membrane proteins which helps maintain cell shape and stabilizes the location the location of certain membrane proteins. Proteins bound to ECM molecules can coordinate extracellular and intracellular changes
Peripheral Proteins
Proteins bound to the surface of the membrane
glycolipid
A membrane carbohydrate that is bound to a lipid
glycoprotein
A membrane carbohydrate that is bound to a protein
Synthesis and sidedness of membranes
Membranes have distinct inside and outside faces (the two lipid layers may differ in composition and each protein has directional orientation)