Chapter 68-74 Flashcards
Pavarotti VCOT 22
Injection of adipose tissue
● Radiographic scores for OA from days 0 to 180 were similar, except in two dogs
● No major side effects were noted after injection
● Lameness and Canine Brief Pain Inventory scores were significantly lower at all time points compared with day 0. Post- injection results demonstrated gradual improvement of kinetic data up to day 180 compared with pre-treatment values: vertical impulse (>2.25%), peak vertical force (>5.32%) and percentages of body weight distribution (>3.6%)
● In dogs with elbow OA, gait analysis values significantly increased at all time points compared with day 0.
Mielke VCOT 18
Spontaneous septic arthritis in dogs
● Pre-existing osteoarthritis was present in 93%
● ALL cases had increased neutrophil counts in synovial fluid
● Only 57% cultured positive
● Despite initial improvements in lameness scores, 92% had residual long term lameness
● Recurrence of infection in 25%
● Acute mortality rate of 9.5% associated with systemic sepsis
Idowu JSAP 18
Relation between Type 1 immune mediated poly arthritis and vax?
No evidence
Maniaki JFMS 21
4 risk factors for mobility changes
○ neuter status at 6 months of age → neutering early decreased risk of mobility issues
○ trauma before 6 years of age
○ outdoor access
○ overweight/obese
Budsberg JAVMA 18
Tramadol usefulness in dogs
● Changes in baseline in VI and PVF were significantly greater with carprofen vs tramadol with elbow or stifle OA.
● CBPI improved for carprofen group; no different in tramadol vs placebo.
● No clinical benefit of tramadol for analgesia of OA
Guedes JAVMA 18
Tramadol in cats
● 2mg/kg Tramadol works well in geriatric cats with osteoarthritis.
● Significant Improvements w/ 2mg/kg PO BID
● Adverse events were dose dependent, higher w/ 4mg/kg dose
Guedes JAVMA 18
Gaba in cats
● Gabapentin decreases pain by suppression of dorsal horn nociceptive neurons and activates descending inhibition by increasing glutamatergic neurotransmission
● Gabapentin associated with:
o Signif lower mean daily activity counts (48,333 vs 39,038 counts/d)
o Signif greater odds (about 3x) of Client-noted improvement
● Conclusion: Gabapentin improved owner-identified impaired activities in OA cats. Activity levels were lower though, sedation was the most common adverse effect.
Shipley JFMS 21
Amantadine in cats
● amantadine - NMDA antagonist
● owners perceived improved clinical signs when treated with amantadine compared to placebo
● activity count was reduced with amantadine treatment compared to control
Hayashi VCOT 21
Synthetic lubricin
● synthetic lubricin is both biocompatible and safe for single administration within the canine stifle joint
Whittemore JVIM 19
Aspirin, pred or combo in dogs
● Gastric mucosal lesion scores increased in the aspirin, prednisone and combo treatment groups
● Dogs receiving prednisone had 11x and dogs receiving combo pred/aspirin had 32x higher odds of GI ulcerative lesions than placebo
● No lesions were associated with clinical signs, however
Allen VS 19
Synovial fluid and lameness
● Concentrations of monocyte chemoattractant protein (MCP)-1, substance P, interleukin (IL)-6, IL-8, KC-like, matrix metalloproteinase (MMP)-1, and MMP-3 were greater in dogs with OA than those without
● MCP-1 was most accurate in distinguishing OA joints from non-arthritic
● Bradykinin and tissue inhibitors of MMP-4 were decreased in OA vs without
● No correlation in any biomarker and lameness severity
Klein VS 19
Leptin and OA
● Serum and synovial fluid leptin was not associated with radiographic severity of OA
● joint fluid leptin correlated with BCS and was weakly associated with LOAD scores
Klein VS 19
Interleukin 8 and OA
● elevated synovial fluid concentrations of IL-8 and MCP-1 in stifle of dogs with OA compared to normal stifles
● no correlation between these and LOAD scores or radiographic severity of OA
Purina Lifetime study
o Body weight correlated moderately w severity of hip osteoarthritis, suggesting that body weight alone might not be the primary driving force for development of hip osteoarthritis in the dog
o Optimal BCS limits the appearance (and progression) of osteoarthritis in dogs
Maniaki JFMS 23
Owners notice DJD in cats?
- There was no significant difference between groups for age category, breed, sex, temperament and body condition score.
- Feline Musculoskeletal Pain Index and orthopaedic examination were able to differentiate cats with early owner-reported signs of impaired mobility from healthy cats.
- VetMetrica Comfort domain scores indicated a compromised quality of life for cats with early owner-reported signs of impaired mobility compared with healthy cats.
o Being able to recognise signs of mobility impairment earlier would allow interventions aimed at slowing disease progression, thereby improving feline health and welfare.
Ravicini JSAP 23
Dogs with immune mediated polyarthritis
- Ninety-five percent (69/73) of dogs responded favourably to therapy although death was attributed to immune-mediated polyarthritis in 19% (14/73) of dogs.
- Relapse of clinical signs was reported in 53% (39/73) dogs (31/39 while on treatment), with multiple relapses observed in 17 dogs.
- Complete cure (permanent withdrawal of immunosup- pressive medication) was achieved in 46 dogs (63%).
- 81% of dogs had a well-managed disease for an extended timeframe (≥1131days). Fourteen of 19 (74%) dogs that started treatment with multi-modal immunosuppression and 32 of 54 (59%) started on corticosteroids alone achieved a complete cure.
- Immunosuppressive therapy was discontinued in the majority of dogs but disease-associated mortality remains high.
Cunningham JFMS 22
Chondrotin in cats
This study showed a strong placebo effect. The glucosamine/chondroitin sulfate supplement did not show pain-relieving effects when compared with placebo
Chalifoux JVIM 23
NSAID toxicosis
excellent prognosis with fluid therapy, lipid emulsion and plasma exchange
overall survival rate 99%
Green JFMS 22
Sphynx cats
● episodes characterized by impaired ambulation due to muscle hypertonicity, most commonly affecting hips and pelvic limbs and shoulders and thoracic limbs
● sudden movement, excitement, and stress identified as possible triggers for episodes
● 2 cats became free of episodes when receiving acetazolamide
● 2 achieved spontaneous remission
Choi VCOT 21
feline skeletal guide
● significant skeletal sex dimorphism exists in cats
● male cat distal limb bones generally longer and wider than female cats
● most significant differences were seen in MC5 and MT5
Anderson VCOT 21
dwarfism in cats
● all limbs from cats with feline disproportionate dwarfism possessed deformities
● humeri demonstrated procurvatum proximally, recurvatum distally
● radii possessed excessive recurvatum proximally and procurvatum distally with varus proximally and valgus distally
● all radii had external torsion
● femurs exhibited varus proximally and varus distally (varus at both levels)
● tibia possessed proximal valgus and distal varus
● no IVDD was seen in any cat
Edwards JVECC 21
Civillian vs working dogs
● penetrating injuries most common, followed by blunt trauma for civilian dogs and operational canines
● explosions accounted for 22% of injuries in military working dog group
● animal bite and motor vehicle accidents were more prevalent in civilian dogs
● gunshot or knife/sharp object more common in military working dogs
Dozeman JVECC 2020
CT for polytrauma
● all patients presented with blunt trauma
● 40% head injury; 25% lung injury, 25% pelvic injury
Wootton JFMS 22
Feline IMPA
Prognosis for feline IMPA can be good. Multimodal immunosuppression was often required. IMPA should be considered in lame cats, with or without pyrexia, when there is no evidence of trauma or infection. The tarsal joints should be included in the multiple joints chosen for sampling. Ligament laxity can occur in non-erosive feline IMPA.