Chapter 27-37 Flashcards
Neuro
Foss JFMS 21
cutaneous truncii in normal cats
80% unilateral
98% bilateral
Fastener JFMS 20
cutaneous truncii in abnormal cats
65% of cats
spinal pain assoc with reflex being present
Mella JFMS 20
feline spinal disease
middle aged purebred - IVDD
older cats - ischemic myelopathy
young cats - fx/luxation
Craciun VCOT 22
Contrast enhanced MRI for IVDE
Gandolium can aid in surgical planning and improve confidence of level of location/extent of extradural material
Tam VRU 22
Vertebral OSA on MRI
has T2 signal heterogeneity, contrast enhancement, and osteolysis on MRI
Contrast enhancement was typically strong and heterogeneous.
Ros JAVMA 22
central cord syndrome
● “central cord syndrome” = clinical presentation where patients show more severe paresis in TL than PL
● 2 locations for central cord syndrome were identified: C1-C5 (90% of the time) and C6-T2 (10%)
● not a negative prognostic
Nakamoto VS 21
myelomalacia with/without extensive hemi
Survival rate was higher in the extensive hemilaminectomy and durotomy group (100% survival) than standard hemilaminectomy (65% survival)
Trouble JVIM 21
Brachial plexus injury
● evaluated compound muscle action potential (CMAP) for return to function
● CMAP was higher in cases that had clinical improvement (4.3 mV vs 0 mV)
● Threshold CMAP >5 mV prognostic for recovery
Lueck JVIM 22
Trazodone administration
- Seven of 32 (22%) dogs had worse scores on their neurologic examination after receiving trazodone, manifesting as new or progressive PR deficits.
o 18.7% of the dogs had consciousness levels that changed from bright, alert, responsive to quiet, alert, responsive after trazodone administration.
o No other changes were observed on neurologic examination. - Sedation and anxiety scores were significantly different after trazodone administration compared to before
- Most dogs did not have changes on neurologic examination after trazodone administration. However, approximately 20% of dogs had new or worsening PR deficits after receiving trazodone. Ideally, trazodone should not be given before neurologic examination in dogs.
Kent JAVMA 19
meningovertebral ligament in dogs
● all dogs had a meningovertebral ligament, which formed the ventral boundary of the epidural space and consisted of fibrous bands that attached the ventral dura mater to the dorsal surface of vertebral bodies
● pathologic structures ventral to the spinal cord adopted a bilobed shape
Cameron JVECC 20
dogs/cats in TBI
● In dogs, nonsurvivors had higher glucose (150 vs 120 mg/dL)–> not in cats
● Modified glasgow coma score was predictive for survivors (higher = better)
Knight JFMS 19
Feline head trauma
● 90% of cases had multiple bones of the skull fractured
● TMJ injury occurred in 60%
● increasing age at presentation and presence of internal upper jaw fractures were risk factors for development of complications
● no risk factors for mortality
Caine JFMS 19
TRI and MRI
● negative outcome in TBI cases with peripharyngeal pattern of injury and orbital trauma
Gomes JFMS 22
Discospondilitis in cats
● all cats presented with spinal hyperesthesia
● Neuro dysfunction seen in 60%
● positive bacterial urine cultures in 11%
● excellent outcome in 85% with conservative management
Kristiansen VCOT 22
Nucleus pulposus extrusion in dogs
● thoracolumbar hydrated nucleus pulposus extrusion was more often painful and extruded disc material was more often lateralized
● TL HNPE were more commonly compressive, more often received surgery
● No difference in outcome between cervical and TL HNPE or conservative vs surgical treatment
Trub JVIM 21
C-reactive protein in disco in dogs
- Serum CRP concentration was significantly more sensitive than were fever and leukocytosis for predicting the presence of diskospondylitis.
- Serum CRP concentration was more sensitive than neutrophilia and hyperglobulinemia. No difference in serum CRP concentration was found between dogs with single or multiple lesions,
- nor between dogs with or without empyema, muscular involvement or spinal cord compression.
- No association was found between serum CRP concentration and positive bacterial culture
- C-reactive protein is a sensitive, but non-specific biomarker for diskospondylitis which may prove useful as an adjunctive diagnostic test in patients with suspicious clinical signs and may help predict prognosis.
Gomes JVIM 22
CT features in disco in dogs
- The most frequently found changes were: (1) endplate involvement (87.3%) most frequently bilateral (94.5%), with erosion (61.9%) and multifocal osteolysis (67.3%); (2) periosteal proliferation adjacent to the IVDS (73%) and spondylosis (66.7%); and (3) vertebral body involvement (66.7%) involving one-third of the vertebra (85.7%) with multifocal osteolysis (73.5%). Other less prevalent features included an abnormal IVDS (narrowed or collapsed), sclerosis of the adjacent vertebral body or endplates, presence of disseminated idiopathic skeletal hyperostosis or vacuum artifact.
- We determined that bilateral endplate erosion and periosteal proliferation were very common in dogs with discospondylitis. Careful evaluation of CT in all 3 planes (dorsal, sagittal, transverse) is necessary to identify an affected IVDS. These described CT features can aid in the diagnosis of discospondyli- tis in dogs but equivocal cases might still require MRI.
West JVIM 23
Non traumatic hemorrhaging myelopathy in dogs
- Non-traumatic spinal cord hemorrhage (NTSH) is an uncommon cause of myelopathy in dogs.
- The onset of signs was acute and progressive in 70% of cases; spinal hyperesthesia was variable (48%).
- Hemorrhage was identified in the thoracolumbar spinal segments in 65% of dogs. An underlying cause was identified in 65% of cases.
- Overall, 64% of dogs had a good or excellent outcome, regardless of cause; which was increased to 100% for SRMA, 75% for A. vasorum and 75% for idiopathic NTSH.
- Outcome was not associated with neurological severity. Recovery rate was 67% and 50% for nociception-intact and nociception-negative dogs, respectively.
Bourbon VRU 23
- Anecdotally, during the review of CT and MRI studies of canine patients including the cranial cervical spine, authors have identified a small osseous structure between the atlas (C1) and axis (C2) with no relevant clinical signs. This structure appeared comparable to a “persistent ossiculum terminale” in humans.
- Mean age was 85 months (6–166) and breed variation was present.
- A total of 20 imaging studies were evaluated: CT was performed in 17 dogs; MRI in three dogs; two dogs had both MRI and CT performed. In all cases the presence of at least one small osseous body on the cranial aspect of the odontoid process compatible with a persistent ossiculum terminale was identified as a possible incidental finding without any overt clinical implications.
- Findings indicated that a small osseous body on the cranial aspect of the odontoid process (presumed persistent ossiculum terminale) in CT and MRI studies may be present in dogs with no clinical signs of neurologic disease.
Planchamp VS 22
CT and MRI cutoff for AA
● cutoff values for ventral compression index >0.16 in extended and > 0.2 in flexed positions were diagnostic for atlantoaxial instability with >95% sensitivity
Planchamp VS 22
Head position for AA
● all transarticular imaging measurements were dependent on head neck position
● recommended a standardized head neck position of 50 degrees flexion
White VE 19
angles for AA
● when flexed lateral radiographs were evaluated with a cutoff value for atlas-to-axis angle >10, evaluation of all breeds revealed a 90% sensitivity and specificity
● recommended 50 flexed lateral views, with AA instability diagnosed if atlas-to-axis angle >10*
● AAA: angle obtained by drawing intersecting lines between roof of C1 and roof of C2
Leblond VCOT 18
trans articular screw vs PMMA AA
● Transarticular screw – achieved better apposition than cemented constructs
● Overall, 5% of screws were in dangerous position
● PMMA group were less prone to failure when mechanically tested
Toni JSAP 20
AA stabilization with bicortical screws
● stabilized using screws and PMMA
● 93% of screws were placed fully within the pedicle; 7% breached medial pedicle wall
● adverse events in 5/12
● 2/12 died postop; 80% of survivors had improvement in Modified Frankel score
Waschk VCOT 18
anomalies in AA
● only dogs with atlantoaxial instability had dens axis anomalies such as separation or abnormal conformation
● patients with AAI were more likely to have other craniovertebral junction abnormalities
Hamilton-Bennet VS 18
3D printed guide for AA
● worked well… used to stabilize caudal cervical instability/fracture; screws placed from ventral
● minor vertebral canal breach in 9%
Argent JSAP 22
recurrent with cervical IVDE
● 30% success with cervical IVDH treated conservatively
● 70% success with cervical IVDH treated surgically
● recurrence of signs in 34% (⅔ of these cases were initially treated conservatively)
● following surgical cases, recurrence of signs was mostly due to disc extrusion at an IVD site adjacent to initial surgery, not at the same site
● rate of recurrence not different between cases managed conservatively and surgically
Olender JAVMA 23
cervical jerk
- Jerks all presented as focal repetitive rhythmic contractions on the lateral aspect of the neck (on one or both sides).
- All dogs had a diagnosis of cervical intervertebral disk extrusion (IVDE), half of them at the C2-C3 level. No dogs presented with extrusion caudal to the C4-C5 interverte- bral disk space.
- Cervical jerk associated with cervical pain or myelopathy may represent myoclonus and was exclusively secondary to cranial cervical IVDE in this study. Full recovery was observed following medical or surgical treatment of IVDE. The exact origin and classification of this involuntary movement has yet to be established.
Murthy JVIM 23
horners syndrome in cervical myelopathy
- Non-compressive disease occurred more frequently in the Horner group compared with controls
o The most common diseases were fibrocartilaginous embolism in the Horner group and intervertebral disc extrusion amongst controls. - On MRI, parenchymal hyperintensity was seen more commonly in the Horner group compared with controls
- In the Horner group, dogs that did not survive to discharge had more extensive MRI lesions relative to the adjacent vertebral length compared with survivors
- Lateralization of Horner signs and MRI changes matched in 54% of cases.
- The overall survival rate was high in both Horner (80/93; 86%) and control (95/99; 96%) groups.
- Horner syndrome in cervical myelopathy is commonly associated with noncompressive intraparenchymal disease.
Albuquerque Bonelli VRU 21
neurologic signs with MRI
● 25% large breed; 75% giant breed
● male predilection
● Dogs with multiple site of compression associated with higher severity of compression and foraminal stenosis
● disc degeneration in 80T of cases
● No age association with severity of compression
Bonelli JAVMA 19
GSD MRI findings with cervical CSM
● 90% male
● 90% chronic signs
● osseous proliferation of the articular processes was seen in 60%
● 80% also had ligamentum flavum (yellow ligament) hypertrophy
Reints VS 19
cervical fusion for caudal CSM
● Used the SynCage spacer then stabilized using two Unilock plates
● pain and neuro scores improved in all dogs
● implant failure in 45%
● Adjacent site pathology in 78% (not clinical)
● ~80% bone ingrowth seen
Nye JVIM 20
long term follow up with osseous CSM
● of sites with stenosis, 45% unchanged, 20% improved, and 40% worsened
● long-term follow did not identify clinical or MRI progression of lesions in the majority of dogs
Albuquerque Bonelli JVIM 23
● Forty of the 60 dogs (67%) had concurrent osseous and disc- associated spinal cord compression in the same location.
○ This was considered the main compression site in 32/40 (80%) dogs.
○ Dogs with osseous- and disc-associated compressions at the same site were more likely to have a higher neurologic grade (P = .04).
● A substantial percentage of dogs with CSM present with concomitant IVD protrusion and osseous proliferations, most at the same site. Characterizing this combined form is important in the management of dogs with CSM because it could affect treatment choices.
Mateo VS 20
ventral access to cd cervical/cr thoracic
● median manubriotomy improved surgical access to the ventral aspect of caudal cervical and cranial thoracic spine without, can be considered in ventral decompression or stabilization cases
Schmidli VCOT 18
2nd cervical fx
● variable severity of neuro signs (cervical pain to tetraparesis)
● 80% had recovery without persistent neuro signs (good recovery seen with both surgical and conservatively managed cases
● low perioperative mortality
Dyall VCOT 18
SSI and hemi
● overall SSI rate 0.6%
● no dogs received perioperative ABX
Zidan JVIM 20
long term PO pain from hemi
● sensory thresholds at the surgery site normalize by 6 months after surgery
● 15% of dogs with spinal cord damage may develop chronic neuropathic pain
Fenn JVIM 20
anesthesia and IVDE
● all dogs had paraplegia with absent pain perception
● confirmed a negative association between increased duration of anesthesia (and surgery) and outcome
Jeffery VS 20
extended durotomy for IVDE
● all dogs (24) paraplegic, deep pain-negative
● performed four-vertebral body length durotomy centered on herniated disc
● No detrimental effects of durotomy - “extended durotomy appears safe and may improve outcome of dogs with severe TL contusion and compression
● 67% recovery of neuro status
Takahashi VS 20
durotomy with IVDE
● percentage of dogs regaining ambulation was better in the durotomy group (57%) than standard hemilaminectomy group (39%)
● No dogs in durotomy group died of myelomalacia; ~20% of hemilaminectomy dogs died of myelomalacia
● performing durotomy in combination with decompression improved return to function and prevented myelomalacia
Gordon-Evans VS 19
BCS and recovery
● increased disability index (i.e. more severe neuro signs) score was associated with increased risk of slow postoperative recovery
● BCS, and age not prognostic
● on average, dogs lost weight and body fat but gained muscle mass with rehab
Mojarradi JSAP 21
hydrotherapy and hemis
● “hydrotherapy is unlikely associated with occurrence of postoperative complications”