Chapter 67 Scleredema and Scleromyxedema

Question 1

mucinoses + excessive collagen deposition

Answer 1

scleredema

Question 2

fibrocyte hyperplasia + mucinoses

Answer 2

scleromyxedema

Question 3

precursor of fibroblasts

Answer 3

cd34+ hema precursors from bone marrow

Question 4

chief role of fibroblasts

Answer 4

deposit collagen, elastin and ground substance

Question 5

major fibroblasts products increased in scleredema

Answer 5

type 1 collagen

hyaluronate

Question 6

most common cause of scleromyxedema

Answer 6

Monoclonal Gammopathy of Unknown Significance (MGUS)

Question 7

differential for scleromyxedema

Answer 7

nephrogenic systemic fibrosis (previously called nephrogenic fibrosing dermopathy)

NSF involves lower dermis but Scleromyxedema is up to mid dermis only

NSF involves pannicular septae but not in scleromyxedema

Question 8

treatment for paraproteinmia

Answer 8

melphalan

also IVIG