Chapter 66 Rheumatoid Arthtritis etc

Question 1

peak age of onset of RA

Answer 1

50

Question 2

most common dermatologic manifestation of RA

Answer 2

rheumatologic nodule

Question 3

true or false

Answer 3

more than 90% of RA patients with RA nodules are positive for RF

Question 4

differentials for rheumatoid nodule

Answer 4

subcutaneous granuloma annulare
foreign body or infectious granuloma
epithelioid sarcoid
necrobiosis lipoidica

Question 5

Felty Syndrome

Answer 5

chronic RA
hypersplenism
leukopenia

Question 6

how many percentage of RA patients have Raynaud phenomenon

Answer 6

5-17%

Question 7

treatment of antiphosphatadylserine prothrombin complex antibody positive for RA ulcers

Answer 7

agatroban - antithrombotic

Question 8

amino acid that is converted to citrulline

Answer 8

arginine

antibodies attack citrullinated proteins in the synovium

Question 9

amino acid that is converted to homocitrulline

Answer 9

lysine

the process is called carbamylation

smoking enhances carbamylation

Question 10

most important HLA associated with RA

Answer 10

HLA DRB1

Question 11

where does RF factor react with

Answer 11

Fc portion of IgG

Question 12

percentage of normal population with RF positivity

Answer 12

3-5%

Question 13

causes of false positive RF

Answer 13

chronic bacterial infection
rubella
hep c
infective endocarditis
lyme disease
ebv
tb

Question 14

JIA with cutaneous findings

Answer 14

paoriatic arthritis

juvenile Still syndrome

Question 15

drug thought to prevent macrophage activation syndrome

Answer 15

canakinra il-1 inhibitor

tocilizumab il-6 inhibitor

Question 16

classic presenting sign of Adult onset Still Diseases (AOSD)

Answer 16

fever temp =/> or higher 39 dec celsius

Question 17

severe complications of AOSD

Answer 17

reactive hemophagocytic lymphohistiocytosis

TTP

malignancy (50% hematologic, 50% solid tumors)

Question 18

spared in erythema marginatum of RF

Answer 18

face

Question 19

non RF erythema marginatum

Answer 19

chicken wire erythem of hereditary angioedema

erythema marginatum hemorrhagixum associated with multikinase sorafenib