Chapter 61 Lupus Erythematosus

Question 1

True or false

ACLE is almost always associated with visceral involvement

Answer 1

True

Question 2

True or False

CLE is more common than LE-arthritis

Answer 2

False

CLE is SECOND most common manifestation of LE next to joint inflammation

Question 3

LE-lichen planus overlap

Answer 3

lupus planus or lichenoid DLE

Question 4

true or false

DLE IS MORE COMMON IN BLACKS

Answer 4

true. less female predilection (3:1) than sle (9:1). localized classic dle —> 5% risk of sle

but scle is more common in white females in ther fifth decade. drug induced on older population

Question 5

spared in generalized ACLE

Answer 5

knuckles

Question 6

consistent clinical difference between SCLE and DLE

Answer 6

dle is indurated

Question 7

rarely face is involved in SCLE; when face is involved, it is locatef where?

Answer 7

lateral

acle is central

Question 8

most common FORM OF CCLE

Answer 8

classic dle

Question 9

when adherent scales is lifted from DLE lesions, keratotic spikes project from undersurface.

this sign is called

Answer 9

carpet tack sign

Question 10

telogen effluvium as a result of acute flaring of SLE (ACLE)

Answer 10

lupus hair

Question 11

involvement of localized classic DLE

Answer 11

head and neck only

Question 12

DLE that is more commonly associated with SLE

Answer 12

generalized DLE

Question 13

true or false

DLE is photosensitive

Answer 13

true

but less than ACLE and SCLE

Question 14

True of False

there is isomorphic effect in LE

Answer 14

true

koebner in LE

Question 15

differentials for hypertrophic DLE

Answer 15

keratoacanthoma
hypertrophic actinic keratosis
squamous cell carcinoma

Question 16

true or false

longstanding DLE does not develop into SCC

Answer 16

False

even mucosal dle develops into scc

Question 17

how many percent of patients with lupus profundus/panniculitia manifest with SLE

Answer 17

50%

Question 18

most photosensitive variant of CCLE

Answer 18

lupus tumidus

no epidermal changes
responsive to antimalatials
intermittent CLE
benign disease course
ANA NEGATIVE
type 1 interferon upregulation

Question 19

autosomal dominant familial form

of chillblain lupus has misense mutation in what gene

Answer 19

TREX 1 (endonuclease repair gene)

Question 20

cell poor interface dermatitis

Answer 20

ACLE

Question 21

marked dermal-epidermal basement membrane junction thickening and follicular plugging

Answer 21

DLE

Question 22

first line therapy for cutaneous lupus

Answer 22

topical class 1 steroid alternate with calcineurin inhibitors

second line: aminoquilines
third line: azathioprine, mycofenolate mofetil, methotrexate

Question 23

side effects of thalidomide

Answer 23

teratogenicity
sensory neuropathy
thromboembolism
somnolence
constipation

Question 24

drug for multiple myeloms that is also effective for CLE

Answer 24

lenalidomide

- thalidomide analogue