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Robbins Pathology MOD1 (Chptr 1-6) > Chapter 6- Hypersensitivity Disorders > Flashcards

Chapter 6- Hypersensitivity Disorders Flashcards

1
Q

What is the mechanism of disease in IBD

A

Inflammation via Th1 and 17 cytokines

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2
Q

What is the mechanism of disease in contact sensitivity

A

Th1 cytokines

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3
Q

What type of hypersensitivity is pernicious anemia

A

Type 2

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4
Q

What is the clinical presentation of contact sensitivity

A

Epidermal necrosis, dermal inflammation, skin rash and blisters

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5
Q

What type of hypersensitivity is SLE

A

Type 3

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6
Q

What is the target antigen of Graves’ disease

A

TSH receptors

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7
Q

What is the clinical presentation of serum sickness

A

Arthritis, vasculitis, nephritis

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8
Q

What is the clinical presentation of pernicious anemia

A

Abnormal erythropoiesis, anemia

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9
Q

What is the mechanism of disease in autoimmune thrombocytopenia purpura

A

Opsonization and phagocytosis of platelets

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10
Q

What is the target antigen in contact sensitivity

A

Environmental antigens (poison ivy)

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11
Q

What is the mechanism of disease in pernicious anemia

A

Neutralization of intrinsic factor, leading to decreased absorption of B12

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12
Q

What is the clinical presentation of Graves’ disease

A

Hyperthyroidism

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13
Q

What type of hypersensitivity is IBD

A

Type 4

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14
Q

What is the clinical presentation of psoriasis

A

Destructive plaques in the skin

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15
Q

What type of hypersensitivity is Rheymatoid arthritis

A

Type 4

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16
Q

What is the clinical presentation of pemphigus vulgaris

A

Skin vesicles (bullae)

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17
Q

What is the target antigen in Rheymatoid arthritis

A

Collagen, citrullinated self proteins

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18
Q

What is the target antigen in Myasthenia gravis

A

ACh receptors

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19
Q

What is the target antigen in goodpasture syndrome

A

Noncollagenous proteins in basement membranes of kidney glomeruli and lung alveoli

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20
Q

What type of hypersensitivity is autoimmune thrombocytopenia purpura

A

Type 2

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21
Q

What type of hypersensitivity is pemphigus vulgaris

A

Type 2

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22
Q

What is the clinical presentation of autoimmune hemolytic anemia

A

Hemolysis, anemia

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23
Q

What type of hypersensitivity is Reactive arthritis

A

Type 3

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24
Q

What is the mechanism of disease in psoriasis

A

Inflammation via TH1 and 17 cytokines

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25
Q

What type of hypersensitivity is acute rheumatic fever

A

Type 2

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26
Q

What is the the target antigen in autoimmune thrombocytopenia purpura

A

Platelet membrane proteins (Gp2b:3a integrins)

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27
Q

What is the target antigen in Reactive arthritis

A

Bacterial antigen (Yersinia)

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28
Q

What type of hypersensitivity is insulin resistant diabetes

A

Type 2

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29
Q

What type of hypersensitivity is psoriasis

A

Type 4

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30
Q

What is the target antigen in acute rheumatic fever

A

Streptococcal cell wall antigen, which reacts with cardiomyocytes

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31
Q

What type of hypersensitivity is polyarteritis nodosa

A

Type 3

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32
Q

What type of hypersensitivity is Graves’ disease

A

Type 2

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33
Q

What is the mechanism of disease in goodpasture syndrome

A

Complement and Fc mediated inflammation

34
Q

What is the mechanism of disease in vasculitis caused by ANCA

A

Neutrophil degranulation and inflammation

35
Q

What is the target antigen in Arthus reaction

A

Various foreign proteins

36
Q

What is the target antigen in vasculitis caused by ANCA

A

Neutrophil granule proteins, causing their release

37
Q

What is the clinical presentation in Reactive arthritis

A

Acute arthritis

38
Q

What is the mechanism of disease in Rheymatoid arthritis

A

Inflammation from Th1 and 17 cytokines

39
Q

What is the clinical presentation of vasculitis caused by ANCA

A

Vasculitis

40
Q

What is the clinical presentation of polyarteritis nodosa

A

Systemic vasculitis

41
Q

What is the clinical presentation of goodpasture syndrome

A

Nephritis, lung hemorrhage

42
Q

What is the target antigen in pemphigus vulgaris

A

Proteins in the intracellular junctions of epidermal cells (epidermal Cadherins)

43
Q

What type of hypersensitivity is goodpasture’s

44
Q

What is the mechanism of disease in insulin resistant diabetes

A

Antibody inhibition of Insulin binding

45
Q

What is the clinical presentation of Arthus reaction

A

Cutaneous vasculitis

46
Q

What type of hypersensitivity is MS

47
Q

What type of hypersensitivity is serum sickness

48
Q

What type of hypersensitivity is is poststreptococcal glomerulonephritis

49
Q

What type of hypersensitivity is Myasthenia gravis

50
Q

What is the mechanism of disease in acute rheumatic fever

A

Inflammation, macrophage activation

51
Q

What is the mechanism of disease in pemphigus vulgaris

A

Antibody mediated activation of proteases leading to disruption of intercellular adhesions

52
Q

What type of hypersensitivity is autoimmune hemolytic anemia

53
Q

What is the target antigen in autoimmune hemolytic anemia

A

RBC membrane proteins (Rh, blood type)

54
Q

What is the clinical presentation of insulin resistant diabetes

A

Hyperglycemia, ketoacidosis

55
Q

What is the target antigen of insulin resistant diabetes

A

Insulin receptor

56
Q

What is the target antigen in poststreptococcal glomerulonephritis

A

Streptococcal cell wall antigens

57
Q

What is the target antigen in SLE

A

Nuclear antigens

58
Q

What is the clinical presentation of Rheymatoid arthritis

A

Chronic arthritis with inflammation, destruction of articular cartilage

59
Q

What type of hypersensitivity is vasculitis caused by ANCA

60
Q

What is the target antigen in pernicious anemia

A

Intrinsic factor in gastric parietal cells

61
Q

What is the clinical presentation of autoimmune thrombocytopenia purpura

62
Q

What type of hypersensitivity is the Arthus reaction

63
Q

What type of hypersensitivity is contact sensitivity

64
Q

What is the target antigen in IBD

A

Enteric bacteria

65
Q

What is the clinical presentation in MS

A

Demyelination of CNS with perivascular inflammation, paralysis

66
Q

What type of hypersensitivity is Type 1 diabetes

67
Q

What is the clinical presentation of IBD

A

Chronic intestinal inflammation and obstruction

68
Q

What is the target antigen in psoriasis

69
Q

What is the target antigen in Type 1 diabetes

A

Antigens of pancreatic islet B cels (insulin, glutamic acid decarboxylase)

70
Q

What is the target antigen in polyarteritis nodosa

A

Hep B virus antigens

71
Q

What is the clinical presentation of Type 1 diabetes

A

Insulitis (inflammation of islets), destruction of B cells

72
Q

What is the clinical presentation in poststreptococcal glomerulonephritis

73
Q

What is the mechanism of disease in MS

A

Inflammation via Th1 AND 17, myeine destruction via macrophages

74
Q

What is the target antigen in MS

A

Protein antigens in myelin (myelin basic protein)

75
Q

What is the mechanism of disease in Graves’ disease

A

Antibody mediated stimulation of TSH receptors

76
Q

What is the target antigen in serum sickness

A

Proteins from foreign serum (horse antithymocyte globulin)

77
Q

What is the clinical presentation of Myasthenia gravis

A

Muscle weakness, paralysis

78
Q

What are the clinical presentations of SLE

A

Nephritis, skin lesions, arthritis, others

79
Q

What is the mechanism of disease in Type 1 diabetes

A

T cell mediated inflammation, destruction via CTL

80
Q

What is the mechanism of disease in autoimmune hemolytic anemia

A

Opsonization and phagocytosis of RBCs

81
Q

What is the mechanism of disease in Myasthenia gravis

A

Ab inhibits ACh binding to receptors, down regulates receptor levels

82
Q

What is the clinical presentation of acute rheumatic fever

A

Myocarditis, arthritis

Robbins Pathology MOD1 (Chptr 1-6) (10 decks)

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