Chapter 6- Hypersensitivity Disorders Flashcards
What is the mechanism of disease in IBD
Inflammation via Th1 and 17 cytokines
What is the mechanism of disease in contact sensitivity
Th1 cytokines
What type of hypersensitivity is pernicious anemia
Type 2
What is the clinical presentation of contact sensitivity
Epidermal necrosis, dermal inflammation, skin rash and blisters
What type of hypersensitivity is SLE
Type 3
What is the target antigen of Graves’ disease
TSH receptors
What is the clinical presentation of serum sickness
Arthritis, vasculitis, nephritis
What is the clinical presentation of pernicious anemia
Abnormal erythropoiesis, anemia
What is the mechanism of disease in autoimmune thrombocytopenia purpura
Opsonization and phagocytosis of platelets
What is the target antigen in contact sensitivity
Environmental antigens (poison ivy)
What is the mechanism of disease in pernicious anemia
Neutralization of intrinsic factor, leading to decreased absorption of B12
What is the clinical presentation of Graves’ disease
Hyperthyroidism
What type of hypersensitivity is IBD
Type 4
What is the clinical presentation of psoriasis
Destructive plaques in the skin
What type of hypersensitivity is Rheymatoid arthritis
Type 4
What is the clinical presentation of pemphigus vulgaris
Skin vesicles (bullae)
What is the target antigen in Rheymatoid arthritis
Collagen, citrullinated self proteins
What is the target antigen in Myasthenia gravis
ACh receptors
What is the target antigen in goodpasture syndrome
Noncollagenous proteins in basement membranes of kidney glomeruli and lung alveoli
What type of hypersensitivity is autoimmune thrombocytopenia purpura
Type 2
What type of hypersensitivity is pemphigus vulgaris
Type 2
What is the clinical presentation of autoimmune hemolytic anemia
Hemolysis, anemia
What type of hypersensitivity is Reactive arthritis
Type 3
What is the mechanism of disease in psoriasis
Inflammation via TH1 and 17 cytokines
What type of hypersensitivity is acute rheumatic fever
Type 2
What is the the target antigen in autoimmune thrombocytopenia purpura
Platelet membrane proteins (Gp2b:3a integrins)
What is the target antigen in Reactive arthritis
Bacterial antigen (Yersinia)
What type of hypersensitivity is insulin resistant diabetes
Type 2
What type of hypersensitivity is psoriasis
Type 4
What is the target antigen in acute rheumatic fever
Streptococcal cell wall antigen, which reacts with cardiomyocytes
What type of hypersensitivity is polyarteritis nodosa
Type 3
What type of hypersensitivity is Graves’ disease
Type 2