chapter 6, 7, 8, 9 Flashcards

1
Q

The nurse is caring for a patient who has jaundice, dark urine, malaise, light-colored stools, nausea, and vomiting. What is this patient most likely experiencing?
A. An idiosyncratic drug effect on the bone marrow
B. Iatrogenic disease of the kidneys
C. Drug toxicity of the liver
D. An allergic reaction

A

C.

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2
Q
The nurse is caring for a patient who is experiencing a respiratory rate of 6 breaths per minute as a result of a large dose of pain medication. Which term most accurately describes this reaction? 
A. side effect
B. Toxicity 
C. Allergic reaction
D. Idiosyncratic effect
A

B.

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3
Q
The nurse is reviewing the laboratory value for a patient prescribed atorvastatin [Lipitor]. Which laboratory value is most useful for monitoring this drug?
A. Aspartate aminotransferase (AST) 
B. Blood urea nitrogen (BUN)
C. International normalized ratio (INR)
 D. C-reactive protein (CRP)
A

A.

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4
Q

The nurse is monitoring for adverse drug reactions (ADRs) of assigned patients. Which patient is most at risk for the development of drug toxicity?
A. A 30-year-old man admitted for altered mental status
B. A 55-year-old woman with abnormal arterial blood gas values
C. A 70-year-old woman with an elevated creatinine level
D. A laboring 25-year-old woman with a positive Homans’ sign

A

C.

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5
Q

he nurse is preparing a staff education inservice about specific safety measures that reduce patient medication errors. Which measure improves safety for patients during care transition?
A. Medication reconciliation
B. MEDWATCH program
C. Risk Evaluation and Mitigation Strategy
D. Regional Medication Safety Program

A

A.

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6
Q

Which nursing action results in the most common cause of fatal medication errors?
A. Miscalculation of dosage Incorrect
B. Miscommunication of drug orders
C. Misreading of the healthcare provider’s handwriting
D. Administering a drug intravenously (IV) instead of intramuscularly (IM)

A

D.

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7
Q
The nurse is caring for a patient prescribed Isoniazid for the treatment of tuberculosis. The nurse should assess for which signs and symptoms of drug-induced liver toxicity? (Select all that apply.)
A.  Nausea 
B.  Malaise 
C.  Jaundice 
D.  Vomiting 
E.  Clear urine
A

A. B. C. D.

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8
Q
Which response would the nurse anticipate when giving two drugs that have a potentiative effect, such as meperidine and Phenergan?
  Increased pain relief
 Increased nausea and vomiting
  Decreased itching
  Increased alertness
A

Increased pain relief

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9
Q

The nurse is preparing a discharge teaching plan to a patient prescribed phenobarbital and oral contraceptives which are known to induce CYP isoenzymes. What patient teaching should the nurse include in the discharge plan?
“Continue taking your medications as prescribed.”
“Condoms are not necessary while taking phenobarbital. It is not an antibiotic.”
“Plan to use another form of birth control while taking phenobarbital.”
“Your dose of birth control pills will be reduced while you are taking phenobarbital.”

A

Plan to use another form of birth control while taking phenobarbital.

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10
Q
The drug the nurse is about to give induces P-glycoprotein (PGP). Which outcome should the nurse expect when this drug is given with other drugs?
  Increased levels of other drugs
  Increased side effects of other drugs
  Reduced absorption of other drugs
  Reduced drug elimination
A

Reduced absorption of other drugs

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11
Q
The nurse is concerned with minimizing adverse drug-drug interactions for the patient. Which drug characteristic could result in the most serious consequences from a drug-drug interaction?
  Low therapeutic range
  High biologic half-life
  Low potency
  First-pass effect
A

Low therapeutic range

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12
Q

The nurse is teaching a patient prescribed felodipine [Plendil] for the treatment of hypertension. Which statement is the most appropriate for the nurse to include in the teaching session?
“Avoid grapefruit juice while you are taking this medication.”
“Do not eat foods high in tyramine such as aged cheese.”
“Herbal agents can help this drug work more effectively.”
“This drug is free of dangerous drug interactions.”

A

Avoid grapefruit juice while you are taking this medication.”

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13
Q
Before administrating the dosage of a prescribed medication, the nurse observes precipitation formation of the intravenous (IV) solution. What is the priority nursing action?
  Verify the prescription.
  Discard the IV solution.
  Prepare another dose to administer.
  Check the expiration date of the drug.
A

Discard the IV solution.

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14
Q
The nurse reviews all of the patient’s prescriptions. Which prescribed medications may cause a detrimental potentiative drug interaction?
  Aspirin and warfarin
  Sulbactam and ampicillin
  Propranolol and albuterol
  Isoniazid and rifampin
A

Aspirin and warfarin

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15
Q

kidney disease can reduce drug excretion, causing:

A

drugs to accumulate in the body

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16
Q

decreased responsiveness to a drug as a result of repeated drug administration

A

tolerance

17
Q

ability of a drug to reach the systemic circulation from its site of administration

A

Bioavailability

18
Q

reduction in drug responsiveness brought on by repeated dosing over a short time

A

Tachyplaxis

19
Q

___ of all pregnant women take at least 1 medication

A

2/3

20
Q

Gross Malformations are produced by exposure to teratogens during the ____ stage

A

embryonic (1st trimester)

21
Q

Renal blood flow is ___ by the 3rd trimester

this increases the _____

A

doubled

glomerular filtration rate

22
Q

During pregnancy moms have increase ___ ___ of some drugs and decreased ___ which makes for an increased time for absorption

A

hepatic metabolism

bowel tone/ mobility

23
Q

In pregnant women, what can these drugs cause:
Heparin- ____
Prostaglandins ____ ______
Aspirin ____ ____ ___ but ___ ____

A

Heparin- osteoporosis
Prostaglandins- uterine contractions
Aspirin- suppress uterine contractions, but increase bleeding

24
Q

Teratogen exposure during the ___ stage usually disrupts function rather than gross anatomy

A

fetal stage

25
Q

Preimplantation Period _____ weeks
Embryonic Period ____ weeks
Fetal Period _____ weeks

A

conception (week 2-4)
3-8 weeks
9 weeks- term

26
Q

Exposure to substances that cause birth defects in babies

A

Teratogenesis

27
Q

FDA Pregnancy Risk Categories:
Category B-
Category C-

A

B- animal studies no risk, no risk 1st trimester (most drugs)
C- risk in animals or no studies

28
Q

___ soluble drugs cross the placenta readily, whereas drugs that are __, __ or ___ ___ cross with difficulty

A

lipid soluble

ionized, polar, or protein bound

29
Q

Teratogen-induced gross malformations result from exposure early in pregnancy (_______) the time of ____

A

weeks 3-8 gestation

organogenesis