CHAPTER 54, ANTICANCER

Question 1

What is primary chemotherapy?

Answer 1

Patients with advanced cancer and alternative treatment is already invalid

Question 2

what is neoadjuvant chemotherapy?

Answer 2

patients with localized cancer and alternative treatment is not that effective

Question 3

what is adjuvant chemotherapy?

Answer 3

treatment following surgery in removal of tumor, with the intention to halt the relapse of the cancer.

Question 4

Capacitabine

Answer 4

Anitmetabolites

Question 5

Cladribine

Answer 5

Antimetabolites

Question 6

Clofarabine

Answer 6

Antimetabolites

Question 7

Cytarabine

Answer 7

Antimetabolites

Question 8

Fludarabine

Answer 8

Antimetabolites

Question 9

5-flourouracil

Answer 9

Antimetabolites

Question 10

Gemcitabine

Answer 10

Antimetabolites

Question 11

6-Mercaptopurine

Answer 11

Antimetabolites

Question 12

Methotrexate

Answer 12

Antimetabolites

Question 13

Nelarabine

Answer 13

Antimetabolites

Question 14

Pralatrexate

Answer 14

Antimetabolites

Question 15

6-thioguanine

Answer 15

Antimetabolites

Question 16

Etoposide

Answer 16

Topoisomerase II Inhibitor

Question 17

tecans

Answer 17

Topoisomerase I inhibitor

Question 18

taxels

Answer 18

Taxanes

Question 19

Vinblastine, Vincristine, Vinorelbine

Answer 19

Vinca alkaloids

Question 20

Bleomycin

Answer 20

Antitumor antibiotic (G2-M phase)

Question 21

Ixabepilone, Eribulin

Answer 21

Antimicrotubule inhibitor

Question 22

other mycin

Answer 22

Anti-tumor antibiotics

Question 23

tins

Answer 23

Platinum analogs

Question 24

cins expt. Mitoxantrone

Answer 24

Anthracyclines

Question 25

Mechlorethamine,Chlorambucil,Cyclophosphamide, Bendamustine, Melphalan, Thiotepa, , Busulfan, Carmustine, Lomustine, Altretamine MOA's?

Answer 25

Forms DNA Cross links, resulting in inhibition of DNA synthesis and function

Question 26

Temozolomide, zine's MOA's?

Answer 26

Methylates DNA and inhibits DNA synthesis and function

Question 27

tin's MOA's?

Answer 27

Forms intrastand and interstand DNA cross-links; binding to nuclear and cytoplasmic proteins

Question 28

where is Vinblastine from?

Answer 28

Vinca rosea

Question 29

what is the vinca alkaloids MOA's?

Answer 29

inhibits mitosis

Question 30

what is the MOA of etoposide?

Answer 30

inhibit topoisomerase II

Question 31

What is the MOA's of tecan's?

Answer 31

inhibit topoisomerase I