CHAPTER 43 (SAS 7 pt.1) _Beta-Lactam & Other Cell Wall- & Membrane-Active Antibiotics Flashcards
What generation of cephalosporin is CEFAZOLIN?
First generation
what generation of cephalosporins CEFADROXIL?
First generation
what generation of cephalosporin is CEFACLOR?
2nd generation
what generation of cephalosporins is CEFAMANDOLE?
2nd generation
what generation of cephalosporins is CEFONIZID?
2nd generation
what generation of cephalosporins is CEFUROXIME?
2nd generation
what generation of cephalosporins is CEFPROZIL?
2nd generation
what generation of cephalosporins is LORACARBEF?
2nd generation
what generation of cephalosporins is CEFORANIDE?
2nd generation
what generation of cephalosporins is CEFACLOR?
2nd generation
what generation of cephalosporins is CEFUROXIME?
2nd generation
what generation of cephalosporins is CEFPROZIL?
2nd generation
what generation of cephalosporins is CEFOXITIN?
2nd generation
what generation of cephalosporins is CEFOTETAN?
2nd generation
what generation of cephalosporins is MOXALACTAM?
Third generation
what generation of cephalosporins is CEF(T)AZIDIME?
Third generation
what generation of cephalosporins is CEFTIZOMINE?
Third generation
what generation of cephalosporins is CEF(T)RIAZONE?
Third generation
what generation of cephalosporins is CEFTIBUTEN?
Third generation
what generation is CEFEPIME?
Fourth generation
what generation of cephalosporins is CEFOPERAZONE?
Third generation
what generation of cephalosporins is CEFOTAXIME?
Third generation
what generation of cephalosporins is CEFIXIME?
Third generation
what generation of cephalosporins is CEFPODOXIME PREXETIL?
Third generation
what generation of cephalosporins is CEFDINIR?
Third generation
what generation of cephalosporins is CEFDITOREN PIVOXIL?
Third generation
what is the classification of AZTREONAM?
Monobactam
Provide 3 beta-lactamase inhibitors
Tazobactam, Sulbactam, Clavulanic acid
what are the carbapenems?
Doripenem, ertapenem, imipenem, meropenem
Vancomycin is isolated from?
Amycolatopsis orientalis
Vancomycin common reactions?
red man syndrome
> is a semisynthetic lipoglycopeptide derived from vancomycin.
has two mechanisms of action. Like
vancomycin, telavancin inhibits cell wall synthesis by binding to
the d-Ala-d-Ala terminus of peptidoglycan in the growing cell
wall. In addition, it disrupts the bacterial cell membrane potential
and increases membrane permeability
Telavancin
what is the classification of daptomycin?
lipopeptide
Daptomycin is from?
Streptomyces roseosporus
Bacitracin is from?
Bacillus subtilis
Cycloserine is from?
Streptomyces orchidaceous
what is the classification of Vancomycin?
Glycopeptide
what is the moa of vancomycin?
inhibits cell wall synthesis by binding to the D-Ala-D-Ala terminus of nascent peptidoglycan
what is the moa of daptomycin?
binds to cell membrane causing depolarization and rapid cell death
what is the moa of penicillin, cephalosporins, carbapenems, monobactams?
inhibits cell wall synthesis
These drugs have greater activity than penicillin against Gram-negative bacteria because of their enhanced ability to penetrate
the Gram-negative outer membrane.
Aminopenicillins, Carboxypenicillins, Ureidopenicillins (Extended-spectrum penicillins)
developed to broaden the spectrum of penicillins against Gramnegative pathogens, including P aeruginosa.
Carboxypenicillins, carbenicillin, ticarcillin
provide examples of b-lactamase inhibitors?
clavulanic acid, tazobactam, sulbactam, Avibactam
is sometimes used to treat community-acquired pneumonia
Cefuroxime
Inhibits cell wall synthesis by binding firmly to the
d-Ala-d-Ala terminus of nascent peptidoglycan pentapeptide
Vancomycin
can cause myopathy
Daptomycin