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PCOL 2 > CHAPTER 43 (SAS 7 pt.1) _Beta-Lactam & Other Cell Wall- & Membrane-Active Antibiotics > Flashcards

CHAPTER 43 (SAS 7 pt.1) _Beta-Lactam & Other Cell Wall- & Membrane-Active Antibiotics Flashcards

1
Q

What generation of cephalosporin is CEFAZOLIN?

A

First generation

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2
Q

what generation of cephalosporins CEFADROXIL?

A

First generation

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3
Q

what generation of cephalosporin is CEFACLOR?

A

2nd generation

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4
Q

what generation of cephalosporins is CEFAMANDOLE?

A

2nd generation

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5
Q

what generation of cephalosporins is CEFONIZID?

A

2nd generation

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6
Q

what generation of cephalosporins is CEFUROXIME?

A

2nd generation

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7
Q

what generation of cephalosporins is CEFPROZIL?

A

2nd generation

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8
Q

what generation of cephalosporins is LORACARBEF?

A

2nd generation

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9
Q

what generation of cephalosporins is CEFORANIDE?

A

2nd generation

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10
Q

what generation of cephalosporins is CEFACLOR?

A

2nd generation

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11
Q

what generation of cephalosporins is CEFUROXIME?

A

2nd generation

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12
Q

what generation of cephalosporins is CEFPROZIL?

A

2nd generation

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13
Q

what generation of cephalosporins is CEFOXITIN?

A

2nd generation

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14
Q

what generation of cephalosporins is CEFOTETAN?

A

2nd generation

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15
Q

what generation of cephalosporins is MOXALACTAM?

A

Third generation

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16
Q

what generation of cephalosporins is CEF(T)AZIDIME?

A

Third generation

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17
Q

what generation of cephalosporins is CEFTIZOMINE?

A

Third generation

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18
Q

what generation of cephalosporins is CEF(T)RIAZONE?

A

Third generation

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19
Q

what generation of cephalosporins is CEFTIBUTEN?

A

Third generation

20
Q

what generation is CEFEPIME?

A

Fourth generation

21
Q

what generation of cephalosporins is CEFOPERAZONE?

A

Third generation

22
Q

what generation of cephalosporins is CEFOTAXIME?

A

Third generation

23
Q

what generation of cephalosporins is CEFIXIME?

A

Third generation

24
Q

what generation of cephalosporins is CEFPODOXIME PREXETIL?

A

Third generation

25
what generation of cephalosporins is CEFDINIR?
Third generation
26
what generation of cephalosporins is CEFDITOREN PIVOXIL?
Third generation
27
what is the classification of AZTREONAM?
Monobactam
28
Provide 3 beta-lactamase inhibitors
Tazobactam, Sulbactam, Clavulanic acid
29
what are the carbapenems?
Doripenem, ertapenem, imipenem, meropenem
30
Vancomycin is isolated from?
Amycolatopsis orientalis
31
Vancomycin common reactions?
red man syndrome
32
> is a semisynthetic lipoglycopeptide derived from vancomycin. > has two mechanisms of action. Like vancomycin, telavancin inhibits cell wall synthesis by binding to the d-Ala-d-Ala terminus of peptidoglycan in the growing cell wall. In addition, it disrupts the bacterial cell membrane potential and increases membrane permeability
Telavancin
33
what is the classification of daptomycin?
lipopeptide
34
Daptomycin is from?
Streptomyces roseosporus
35
Bacitracin is from?
Bacillus subtilis
36
Cycloserine is from?
Streptomyces orchidaceous
37
what is the classification of Vancomycin?
Glycopeptide
38
what is the moa of vancomycin?
inhibits cell wall synthesis by binding to the D-Ala-D-Ala terminus of nascent peptidoglycan
39
what is the moa of daptomycin?
binds to cell membrane causing depolarization and rapid cell death
40
what is the moa of penicillin, cephalosporins, carbapenems, monobactams?
inhibits cell wall synthesis
41
These drugs have greater activity than penicillin against Gram-negative bacteria because of their enhanced ability to penetrate the Gram-negative outer membrane.
Aminopenicillins, Carboxypenicillins, Ureidopenicillins (Extended-spectrum penicillins)
42
developed to broaden the spectrum of penicillins against Gramnegative pathogens, including P aeruginosa.
Carboxypenicillins, carbenicillin, ticarcillin
43
provide examples of b-lactamase inhibitors?
clavulanic acid, tazobactam, sulbactam, Avibactam
44
is sometimes used to treat community-acquired pneumonia
Cefuroxime
45
Inhibits cell wall synthesis by binding firmly to the d-Ala-d-Ala terminus of nascent peptidoglycan pentapeptide
Vancomycin
45
can cause myopathy
Daptomycin

PCOL 2 (6 decks)

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