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PCOL 2 > CHAPTER 51_ANTUPROTOZOAL ACTIVITY > Flashcards

CHAPTER 51_ANTUPROTOZOAL ACTIVITY Flashcards

1
Q

what is the class of chloroquine?

A

4-aminoquinoline

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2
Q

what is the class of Amodiaquine?

A

4-aminoquinoline

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3
Q

what is the class of piperaquine?

A

Bisquinoline

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4
Q

what is the class of quinine?

A

quinoline methanol

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5
Q

what is the class of quinidine?

A

quinoline methanol

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6
Q

what is the class of mefloquine?

A

quinoline methanol

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7
Q

what is the class of primaquine?

A

8-aminoquinoline

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8
Q

what is Sulfadoxine-pyrimethamine (Fansidar) class?

A

folate antagonist combination

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9
Q

what is the Atovaquone-proguanil (Malarone) class?

A

Quinone folate antagonist combination

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10
Q
  • This drug probably acts by concentrating in parasite vacuoles, preventing the biocrystallization of the hemoglobin product, heme, into hemozin and thus eliciting parasite toxicty due to buildup of free heme
  • part of 4-aminoquinoline
A

Chloroquine

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11
Q

Has an adverse effect of pruritus (spec. in africans), anorexia, urticacia, alopecia

A

Chloroquine

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12
Q

is combined with artesunate

A

Amodiaquine

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13
Q

what is tissue schizonticides?

A

drugs that eliminate developing or dormant liver forms

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14
Q

what is blood schizonticides?

A

drugs that act on erythrocytic parasites

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15
Q

what is gametocides?

A

drugs that kill sexual stages and prevent transmission to mosquitos

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16
Q

what are the four classes of plasmodium?

A

Plasmodium ovale, Plasmodium malariae, Plasmodium vivax, Plasmodium falciparum, Plasmodium knowlesi

17
Q

what is the class of doxycycline?

A

Tetracycline

18
Q

what is the class of Halofantrine?

A

Phenanthrene methanol

19
Q

what is the class of Lumefantrine?

A

Amyl alcohol

20
Q

what is the class of pyronaridine?

A

Mannich base acridine

21
Q

what is the class of artemisinins?

A

Sesquiterpene lactone endoperoxides

22
Q

This drug is used in areas without resistant to P falciparum

A

Chloroquine

23
Q

This drug is used in areas with chloroquine-resistant P falciparum

A

Mafloquine & Malarone

24
Q

this drug is used in areas with multidrug-resistant P falciparum

A

Doxycycline

25
Q

what is the drug therapy for chloroquine-sensitive P falciparum and P malariae infection

A

Chloroquine phosphate

26
Q

what is the drug therapy for P vivax and P ovale infections

A

Chloroquine then, Primaquine

27
Q

what is the drug therapy for uncomplicated infections with chloroquine-resistant P falciparum

A

Coartem

28
Q

what is the drug therapy for severe with severe or complicated infections with P falciparum

A

Artesunate, Quinidine gluconate

29
Q

what are the WHO recommendation treatment for the falciparum malaria.

A

Artesunate-mefloquine
Artesunate-Amodiaquine
Artemether-lumefantrine

30
Q

What is the MOA of chloroquine?

A

inhibit the formation of hemozoin from heme released by the digestion of hemoglobin

31
Q

this drug can be used in babesiosis

A

Quinine

32
Q

Has an adverse effect of cinchonism

A

Quinine and quinidine

33
Q

what is the moa of pyrimethamine and proguanil?

A

inhibit plasmodial dihydrofolate reductase

PCOL 2 (6 decks)

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