CHAPTER 51_ANTUPROTOZOAL ACTIVITY

Question 1

what is the class of chloroquine?

Answer 1

4-aminoquinoline

Question 2

what is the class of Amodiaquine?

Answer 2

4-aminoquinoline

Question 3

what is the class of piperaquine?

Answer 3

Bisquinoline

Question 4

what is the class of quinine?

Answer 4

quinoline methanol

Question 5

what is the class of quinidine?

Answer 5

quinoline methanol

Question 6

what is the class of mefloquine?

Answer 6

quinoline methanol

Question 7

what is the class of primaquine?

Answer 7

8-aminoquinoline

Question 8

what is Sulfadoxine-pyrimethamine (Fansidar) class?

Answer 8

folate antagonist combination

Question 9

what is the Atovaquone-proguanil (Malarone) class?

Answer 9

Quinone folate antagonist combination

Question 10

• This drug probably acts by concentrating in parasite vacuoles, preventing the biocrystallization of the hemoglobin product, heme, into hemozin and thus eliciting parasite toxicty due to buildup of free heme
• part of 4-aminoquinoline

Answer 10

Chloroquine

Question 11

Has an adverse effect of pruritus (spec. in africans), anorexia, urticacia, alopecia

Answer 11

Chloroquine

Question 12

is combined with artesunate

Answer 12

Amodiaquine

Question 13

what is tissue schizonticides?

Answer 13

drugs that eliminate developing or dormant liver forms

Question 14

what is blood schizonticides?

Answer 14

drugs that act on erythrocytic parasites

Question 15

what is gametocides?

Answer 15

drugs that kill sexual stages and prevent transmission to mosquitos

Question 16

what are the four classes of plasmodium?

Answer 16

Plasmodium ovale, Plasmodium malariae, Plasmodium vivax, Plasmodium falciparum, Plasmodium knowlesi

Question 17

what is the class of doxycycline?

Answer 17

Tetracycline

Question 18

what is the class of Halofantrine?

Answer 18

Phenanthrene methanol

Question 19

what is the class of Lumefantrine?

Answer 19

Amyl alcohol

Question 20

what is the class of pyronaridine?

Answer 20

Mannich base acridine

Question 21

what is the class of artemisinins?

Answer 21

Sesquiterpene lactone endoperoxides

Question 22

This drug is used in areas without resistant to P falciparum

Answer 22

Chloroquine

Question 23

This drug is used in areas with chloroquine-resistant P falciparum

Answer 23

Mafloquine & Malarone

Question 24

this drug is used in areas with multidrug-resistant P falciparum

Answer 24

Doxycycline

Question 25

what is the drug therapy for chloroquine-sensitive P falciparum and P malariae infection

Answer 25

Chloroquine phosphate

Question 26

what is the drug therapy for P vivax and P ovale infections

Answer 26

Chloroquine then, Primaquine

Question 27

what is the drug therapy for uncomplicated infections with chloroquine-resistant P falciparum

Answer 27

Coartem

Question 28

what is the drug therapy for severe with severe or complicated infections with P falciparum

Answer 28

Artesunate, Quinidine gluconate

Question 29

what are the WHO recommendation treatment for the falciparum malaria.

Answer 29

Artesunate-mefloquine Artesunate-Amodiaquine Artemether-lumefantrine

Question 30

What is the MOA of chloroquine?

Answer 30

inhibit the formation of hemozoin from heme released by the digestion of hemoglobin

Question 31

this drug can be used in babesiosis

Answer 31

Quinine

Question 32

Has an adverse effect of cinchonism

Answer 32

Quinine and quinidine

Question 33

what is the moa of pyrimethamine and proguanil?

Answer 33

inhibit plasmodial dihydrofolate reductase