CHAPTER 51_ANTUPROTOZOAL ACTIVITY Flashcards
what is the class of chloroquine?
4-aminoquinoline
what is the class of Amodiaquine?
4-aminoquinoline
what is the class of piperaquine?
Bisquinoline
what is the class of quinine?
quinoline methanol
what is the class of quinidine?
quinoline methanol
what is the class of mefloquine?
quinoline methanol
what is the class of primaquine?
8-aminoquinoline
what is Sulfadoxine-pyrimethamine (Fansidar) class?
folate antagonist combination
what is the Atovaquone-proguanil (Malarone) class?
Quinone folate antagonist combination
- This drug probably acts by concentrating in parasite vacuoles, preventing the biocrystallization of the hemoglobin product, heme, into hemozin and thus eliciting parasite toxicty due to buildup of free heme
- part of 4-aminoquinoline
Chloroquine
Has an adverse effect of pruritus (spec. in africans), anorexia, urticacia, alopecia
Chloroquine
is combined with artesunate
Amodiaquine
what is tissue schizonticides?
drugs that eliminate developing or dormant liver forms
what is blood schizonticides?
drugs that act on erythrocytic parasites
what is gametocides?
drugs that kill sexual stages and prevent transmission to mosquitos
what are the four classes of plasmodium?
Plasmodium ovale, Plasmodium malariae, Plasmodium vivax, Plasmodium falciparum, Plasmodium knowlesi
what is the class of doxycycline?
Tetracycline
what is the class of Halofantrine?
Phenanthrene methanol
what is the class of Lumefantrine?
Amyl alcohol
what is the class of pyronaridine?
Mannich base acridine
what is the class of artemisinins?
Sesquiterpene lactone endoperoxides
This drug is used in areas without resistant to P falciparum
Chloroquine
This drug is used in areas with chloroquine-resistant P falciparum
Mafloquine & Malarone
this drug is used in areas with multidrug-resistant P falciparum
Doxycycline
what is the drug therapy for chloroquine-sensitive P falciparum and P malariae infection
Chloroquine phosphate
what is the drug therapy for P vivax and P ovale infections
Chloroquine then, Primaquine
what is the drug therapy for uncomplicated infections with chloroquine-resistant P falciparum
Coartem
what is the drug therapy for severe with severe or complicated infections with P falciparum
Artesunate, Quinidine gluconate
what are the WHO recommendation treatment for the falciparum malaria.
Artesunate-mefloquine
Artesunate-Amodiaquine
Artemether-lumefantrine
What is the MOA of chloroquine?
inhibit the formation of hemozoin from heme released by the digestion of hemoglobin
this drug can be used in babesiosis
Quinine
Has an adverse effect of cinchonism
Quinine and quinidine
what is the moa of pyrimethamine and proguanil?
inhibit plasmodial dihydrofolate reductase
