Chapter 5 - Cell recognition and the immune system Flashcards
What is an infection?
An interaction between the pathogen and the defence mechanisms of the body
What is an antigen?
A protein found on the cell surface of pathogens that generate an immune response
What is a pathogen?
A disease-causing microorganism
What is immunity?
When the body is well equipped against invasion from a pathogen so it doesn’t harm the individual
What must lymphocytes do before attacking an invader?
Distinguish between cells that belong to the individual and cells that don’t
What are the four things that the immune system can identify?
Pathogens, non-self material, toxins and abnormal body cells
Why can the immune system be a problem when receiving organ donations?
The antigens are recognised as non-self, so without immunosuppressants, the immune system would try and attack it
What is a non-specific response?
The response is immediate and the same for all pathogens
What is a specific response?
The response is slower and specific to each pathogen
Two types of non-specific response
Physical barriers and phagocytosis
Two types of specific response
Cell-mediated response and humoral response
How many types of lymphocyte are there?
10 million
How do lymphocytes recognise cells belonging to the body?
In the womb, lymphocytes are constantly colliding with the body cells of the fetus
Some lymphocytes will have sites that are complementary to these cells
These will either die or be suppressed
The remaining lymphocytes are those that are complementary to non-self material that the fetus hasn’t yet been exposed to
In adults, the same process happens in the bone marrow, producing only lymphocytes that will be able to fight an infection
What are the two types of white blood cell?
Phagocyte and lymphocyte
Process of phagocytosis
A phagocyte recognises foreign antigens on the pathogen
Receptors on the phagocyte bind to the pathogen
They engulf the pathogen, forming a phagosome
Lysosomes fuse with the phagosome
Lysozymes hydrolyse the cell walls of the bacteria, breaking it down
The phagocyte presents the antigens of the pathogen on its surface
What are the two types of lymphocyte?
B lymphocyte
T lymohocyte
Where do B lymphocytes mature?
Bone marrow
Where do T lymphocytes mature?
Thymus gland
What type of immunity are B cells associated with?
Humoral
What type of immunity are T cells associated with?
Cell-mediated
What are antigen presenting cells?
Cells that can present foreign antigens on their surface
How do T cells recognise cells to destroy?
They display foreign antigens
How do T cells help to destroy pathogens?
Receptors on the T helper cells are complementary to the antigens presented on the surface of phagocytes
This attachment stimulates the T cell to divide rapidly by mitosis, forming cloned cells
These cells can do one of four things
What are the four things that can happen to T cells after they have been cloned?
a) memory cells
b) stimulate phagocytes for phagocytosis
c) stimulate B cells
d) activate cytotoxic t cells
How do cytotoxic T cells kill cells?
They produce a protein called perforin, which creates holes in the cell surface membrane so the cell loses control of what enters and leaves and the cell dies
What is humoral response?
Response to infection using antibodies
What is clonal selection?
Each B cell has a differently shaped active site, which is complementary to only one antigen. When the body is infected with the pathogen with this antigen, the B cell engulfs it and displays the antigen. TH cells bind to this displayed antigen and stimulate the B cell to divide by mitosis
What is the name of the process by which B cells display a foreign antigen on their cell surface?
Endocytosis
When B cells are cloned, what are the two things they can turn into?
Memory cells, or plasma cells
What type of cell is responsible for the primary defence?
Plasma cells
What do plasma cells do?
They bind to the antigen to form an antibody-antigen complex
How do plasma cells kill pathogens?
Antibodies have two binding sites, meaning they can bind to multiple pathogens at once. This causes them to clump together (agglutination) so phagocytes recognise and destroy them
How do memory cells help to kill pathogens?
They coordinate the secondary response - when you are infected again, they divide rapidly to produce plasma cells (which secrete antibodies) and more memory cells so there is less chance of you becoming ill
Why is the primary immune response so slow?
There aren’t many B cells that can secrete the antibody needed to fight the pathogen
What happens during the primary immune response?
You show signs of the disease - it takes time for the necessary B cells to be made. Then, memory cells are made, which make the secondary response faster