Chapter 5 Flashcards

1
Q

Acetylcholine

A

First neurotransmitter discovered in the peripheral and central nervous system.

Activates skeletal muscles in the somatic nervous system and may either excite or inhibit internal organs in the autonomic system.

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2
Q

Epinephrine (/adrenaline)

A

Chemical messenger that acts as a hormone to mobilize the body for fight or flight during times of stress and as a neurotransmitter in the central nervous system.

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3
Q

Norepinephrine

A

Neurotransmitter found in the brain and in the sympathetic division of the autonomic nervous system.

Accelerates hear rate in mammals.

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4
Q

Neurotransmitter

A

Chemical released by a neuron into a target with an excitatory or inhibitory effect.

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5
Q

Parkinson’s Disease

A

Disorder of the motor system correlated with a loss of dopamine in the brain and characterized by tremors, muscular rigidity, and reduction of voluntary movement.

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6
Q

Dopamine

A

Amine neurotransmitter that plays a role in coordinating movement in attention and learning in behaviours that are reinforcing.

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7
Q

Synaptic Vesicle

A

Organelle consisting of a membrane structure that encloses a quantum of neurotransmitter.

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8
Q

Synaptic Cleft

A

Gap that separates the presynaptic membrane from the postsynaptic membrane.

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9
Q

Chemical Synapse

A

Junction at which messenger molecules are released when stimulated by an action potential.

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10
Q

Presynaptic Membrane

A

Membrane on the transmitter-output side of a synapse

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11
Q

Postsynaptic Membrane

A

Membrane on the transmitter-input side of a synapse.

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12
Q

Storage Granule

A

Membranous compartment that holds several vesicles containing a neurotransmitter

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13
Q

Gap Junction

A

Fused prejunction and postjunction cell membrane in which connected ion channels form a pore that allows ions to pass directly from one neuron to the next

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14
Q

What are the four steps of neurotransmission?

A

Synthesis
Release
Receptor Activation
Inactivation

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15
Q

Transporter

A

Protein molecule that pumps substance across a membrane

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16
Q

What locations are neurotransmitters often found?

A

Granules, microfilaments in terminal, and presynaptic membrane

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17
Q

Transmitter-Activated Receptors

A

Protein that has a binding site for a specific neurotransmitter and is embedded in the membrane of a cell

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18
Q

Autoreceptor

A

“Self receptor” in a neural membrane that responds to the transmitter released by the neuron.

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19
Q

What are the four ways in which neurotransmitter deactivation is achieved?

A

Diffusion, degradation, reuptake, glial uptake

20
Q

What is the difference between type 1 and type 2 synapses?

A

Type 1: excitatory, located on shaft or spine of dendrite, round dense and large synapses
Type 2: inhibitory, located on the cell body, flat less dense and smaller

21
Q

Small Molecule Transmitter

A

Quick acting neurotransmitter synthesized in the axon terminal from products derived from the diet.

22
Q

What are the four criteria for identifying neurotransmitters?

A
  1. Chemical must be synthesized by or present in neuron
  2. When the neuron is active the chemical must be released and produce a response in some target
  3. Same response must be obtained when the chemical is experimentally placed on the target
  4. A mechanism must exist for removing the chemical from it;s site of activation after its work is done.
23
Q

Histamine

A

Neurotransmitter that controls arousal and waking

24
Q

What are the three classes of neurotransmitters?

A

Small molecule transmitters
Peptide transmitters
Transmitter gasses

25
Q

Serotonin

A

Amine neurotransmitter that plays a role in regulating mood and aggression appetite and arousal. The perception of pain and respiration.

26
Q

Glutamate

A

Amino acid neurotransmitter that excites neurons.

27
Q

Gamma-Aminobutyric Acid (GABA)

A

Amino acid neurotransmitter that inhibits neurons

28
Q

Neuropeptide

A

Multifunctional chain of amino acids that acts as a neurotransmitter

Synthesized from mRNA
Can act as hormones and may contribute to learning

29
Q

Nitric Oxide

A

Gas that acts as a chemical neurotransmitter

Dilate blood vessels aid digestion and activate cellular metabolism.

30
Q

Carbon Monoxide

A

Gas that acts as a neurotransmitter in the activation of cellular metabolism

31
Q

Ionotropic Receptors

A

Embedded membrane protein that acts as…

  1. A binding side for a neurotransmitter
  2. A pore that regulates ion flow to directly and rapidly change membrane voltage
32
Q

Metabotropic Receptor

A

Embedded membrane protein with a binding site for a neurotransmitter but no pore.

Generall inhibitory, slow acting, and activate second messengers.

33
Q

Second Messenger

A

Chemical that carries a message to initiate a biochemical process when activated by a neurotransmitter

34
Q

Cholinergic Neuron

A

Neuron that uses acetylcholine as its main neurotransmitter

35
Q

Activating System

A

Neural pathways that coordinate brain activity through a single neurotransmitter

36
Q

What are the four activating systems?

A

Cholinergic System
Dopaminergic System
Noradrenergic System
Serotonergic System

37
Q

Cholinergic System

A

Active in maintaining attention and waking patterns.
Plays a role in memory.

Thought to be related to Alzheimers disease.

38
Q

Dopaminergic System

A

Made of nigrostriatial and mesolimbic pathways

Thought to play a role in Parkinson’s Disease

39
Q

Nigrostriatial Pathways

A

Maintains normal motor behaviour

40
Q

Mesolimbic Pathways

A

Reward Pathways

41
Q

Noradrenic System

A

Maintaining Emotional Tone

Related to mania and depression

42
Q

Serotonergic System

A

Maintaining waking brain activity

Thought to be related to OCD

43
Q

Habituation

A

Learning behaviour in which a response to a stimulus weakens with repeated stimulus presentations.

44
Q

Sensitization

A

Learning behaviour in which the response to a stimulus strengthens with repeated presentations of that stimulus because the stimulus is novel or because the stimulus is stronger than normal.

45
Q

In sensitization, change takes place in which channel?

A

Potassium

46
Q

In habituation change takes place in which channels?

A

Calcium