Chapter 5

Question 1

ligand

Answer 1

molecule reversibly bound by protein

Question 2

Why is CO deadly?

Answer 2

competes with oxygen for binding to heme

Question 3

myoglobin structure

Answer 3

single polypeptide of 153 residues arranged in 8 a-helices

Question 4

Mb P50?

Answer 4

3 torr

Question 5

Hb P50?

Answer 5

30 torr

Question 6

Partial pressure ________ as you move away from lungs

Answer 6

decreases.

Question 7

R-state

Answer 7

active

Question 8

T-state

Answer 8

inactive

Question 9

allosteric modulators/effectors

Answer 9

activators or inhibitors and bind to allosteric proteins at sites separate from functional binding site

Question 10

heterotropic interaction

Answer 10

modulator is different from normal ligand

Question 11

Oxygen is a _______________________ of hemoglobin

Answer 11

homotropic allosteric activator

Question 12

oxygen binding promotes …..

Answer 12

R state

Question 13

Which has higher O2 affinity…. R or T state?

Answer 13

R state

Question 14

bisphosphoglycerate

Answer 14

decrease Hb affinity for oxygen

-heterotropic allosteric inhibitor of Hb

Question 15

BPG

Answer 15

carries 5 units of negative charge and binds to the positively charged pockets of Hb

Question 16

binding of BPG by Hb governed by…

Answer 16

electrostatic interactions

Question 17

sickle cell anemia

Answer 17

changes properties red blood cells to rigid and no flexibility to squeeze in capillaries … blocking blood flow

Question 18

sickle cell anemia fibers

Answer 18

form in capillaries where oxygen is lowest, blocks blood flow to extremities

Question 19

malaria infects…

Answer 19

decreases pH in red blood cells, causes release of oxygen

Question 20

some invertebrates use _______ instead of Hb

Answer 20

hemocyanin

Question 21

hemocyanin uses…

Answer 21

copper rather than iron