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Behavioural Neuroscience > Chapter 5 > Flashcards

Chapter 5 Flashcards

1
Q

What’s a receptor protein?

A

A protein that is sensitive to and capable of communicating some signal.

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2
Q

What types of receptors are there?

A

Ionotropic and Metabotropic

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3
Q

What is an ionotropic receptor?

A

A receptor protein that is an ion chanel

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4
Q

What determines if an ionotropic receptor will produce EPSP or IPSPs?

A

The properties of the pore of the ion channel

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5
Q

What is the effect of the activation of an ionotropic receptor

A

Immediate change in the permeability of the membrane to specific ions

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6
Q

What is a metabotropic receptor?

A

A receptor protein that is not an ion channel

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7
Q

What do metabotropic receptors typically trigger? What do they produce?

A

They typically trigger an intracellular signaling cascade that involves g proteins.
They can produce a variety of cellular effect

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8
Q

What is special about the effect of metabotropic signaling? Why?

A

They can be large but they are often delayed.
Because they rely on signaling cascades and diffusion

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9
Q

What are GPCRs (g protein coupled receptors)?

A

Metabotropic receptors

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10
Q

What do ionotropic receptors “turn toward” in order to mediate their effect?

A

ions

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11
Q

What do metabotropic receptors turn towards to mediate their effects?

A

metabolism

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12
Q

What does metabolism refer to?

A

Chemical reactions that occur inside of cells

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13
Q

What do activated metabotropic receptors trigger? What is the end result?

A

Intracellular signals to catalyze chemical reactions.
Almost anything, but usually a change in gene expression or the opening of intracellularly gated ion channels

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14
Q

How do most metabotropic receptors mediate their effects?

A

Activating g proteins

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15
Q

What does the name “g” protein symbolize?

A

That these proteins use GTP molecules, instead of ATP molecules, for the energy they need to perform chemical reactions

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16
Q

What happens when a g protein is bound to GTP? Why?

A

It is “on” or activated. Because in this state, it can trigger chemical reactions

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17
Q

When a g protein is bound to GTP and can trigger chemical reactions, is this state temporary? why or why not?

A

Yes, it’s temporary because G proteins have a natural tendancy to convert GTP into GDP

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18
Q

What happens when a G proteins converts GTP into GDP?

A

The g protein is “off” or inactive

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19
Q

How can G proteins let go of GDP?

A

It’s hard, they can only let go of it by finding an activated metabotropic receptor. They use the intracellular side of an activated metabotropic receptor to pry off their GDP molecule. When this happens the G protein is “off” or “inactived

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20
Q

What is the activation cycle of g proteins?

A
  1. Ligand binding to a metabotropic receptor
    which induces…
  2. Conformational change that facilitates the exchange of GDP for GTP on the a subunit of the G protein complex
  3. The g proteins then disassociate and diffuse away to activate downstream enzymes
  4. Once the GTP molecule is metabolized (GTP to GDP) the original G protein coupled receptor complex is restored
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21
Q

What is a G protein-gated ion channel?

A

An ion channel gated by G proteins

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22
Q

What are G proteins family?

A

A family of intracellular proteins that are involved in intracellular signaling cascades

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23
Q

Give a generalized illustration of a metabotropic GPCR receptor causing ion channel opening.

A
  1. Neurotransmitter binds to a metabotropic receptor
  2. Activated G proteins transmit the message intracellularly
  3. Some ion channels are gated (directly or indirectly) by activated g proteins
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24
Q

What can G protein signaling cascades affect?

A

Multiple downstream processes:
-opening g protein gated ion channels
- changes in gene transcription
- secretion of substances from the cell

… really anything the cell wants

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25
Where can synapses from? Between axon terminals and ....?
1. Dendrites (dendritic shafts) 2. dendritic spines 3. Soma (cell body) 4. Other axon terminal (axoaxonic synapses)
26
What are axoaxonic synapses?
axon terminals on other axon terminals
27
What do axoaxonic synapses do?
Regulate the amount of neurotransmitter that the second neuron will release when it has an action potential.
28
What is presynaptic inhibition in axoaxonic synapses?
Axoaxonic synapses can hyperpolarize the axon terminal of the downstream neuron, so that its voltage gated calcium channels will not open at all or for very long when an action potential arrives. The effect: reduce neurotransmitter release when it has an action potential
29
What is presynaptic facilitation in axoaxonic synapses?
Axoaxonic synapses can depolarize the axon terminal of the downstream neuron, so that its voltage gated calcium channels are more likely to open when an action potential arrives. Effect: increase neurotransmitter release when it has an action potential
30
What is an autoreceptor?
A receptor located on the presynaptic membrane that gets activated when the cell releases its own neurotransmitter
31
What are autoreceptors gated by?
The neurotransmitter that the cell releases
32
Are autoreceptors generally metabotropic/ionotropic? Inhibitory or excitatory?
Metabotropic and inhibitory
33
What is the main source of presynaptic inhibition?
Autoreceptors
34
What is the postsynaptic receptor?
The receptor located on the receiving neuron, the one that is not releasing the neurotransmitter
35
What is the CNS (central nervous system?
Everything in the brain and spinal cord
36
What is the PNS (peripheral nervous system)?
Any part of the nervous systejm outside the brain and spinal cord, including the nerves attached to the brain and spinal cord.
37
What is the difference between the production of myelin in the CNS and PNS
In the CNS: myelin is created by oligodendrocytes In the PNS: myelin is created by schwann cells
38
What is the blood brain barrier?
The semipermeable barrier between the blood and the brain
39
Where does extracellular fluid come from outside the brain and spinal cord?
blood
40
How does plasma leak out of the blood vessels in the body? What is this called?
Blood vessels have little holes in them, which allows blood plasma to leak out. Lymph.
41
What does lymph do?
Flows around cells, providing nutrients and collecting waste.
42
Where is lymph collected? Where is it brought to? What do these structures do?
It is collected into lymph vessels. It is brought to lymph nodes/lymph organs. These structures detect and destroy any invading organisms of foreign particles and then they return the lymph back to the blood to start the process again.
43
Does the CNS particpate in the lymphatic system? Why? What's this property called?
No. Because the blood capillaries that pass through the brain and spinal cord do not have gaps in them. The blood brain barrier.
44
What does the CNS do instead of lymph?
It makes its own extracellular solution by picking out exactly what it needs from the blood. The solution it makes is called cerebrospinal fluid (CSF)
45
What are meninges?
Tough, protective connective tissues that surround the brain.
46
What is dura mater?
A meninge, the outer layer which is the thick, tough and unstretchable tissue.
47
What is the arachnoid membrane?
A meninge, the middle layer which is soft and spongy and has a web like appearance
48
What is pia mater?
A meninge, the third layer (which sits closest to the brain), this layer and the space above it has blood vessels in it
49
Where is the subarachnoid space? What is it filled with?
It is between the arachnoid membrane and pia mater. It is filled with cerebrospinal fluid (CSF)
50
What are ventricles?
Four interconnected hollow spaces within the brain.
51
What is produced in the ventricles? How?
Cerebrospinal fluid. From tissue called Choroid plexus.
52
Lateral ventricles: size: where do they sit:
Large. underneath the cerebrum
53
Where does the third ventricle lie?
Between the two thalamic nulcei
54
Where does the fourth ventricle sit?
between the pons and cerebellum
55
Cerebral aqueduct: size: structure: what does it connect:
long tube like structure it connect the third and fourth ventricle
56
What does CSF do before its absorbed into the blood supply?
Exits the ventricles and flows around the brain and spinal cord - in the subarachnoid space.
57
How often is CSF made? What is the half life?
CSF is made continuously. It is half replaced every three hours
58
What is a neuron entirely located in the CNS technically called? What is the word interneuron used to describe? What is the term projection neuron used to describe?
Interneuron.. Only used for CNS neuons whose axons stay local : it only makes synapses on nearby neurons Used when the axon of a cell goes outside the area where its soma is located
59
What system are the axons of motor neurons a part of?
the PNS
60
What are axons of motor neurons? which means? What do motor neurons control? Where is the soma of motor neurons located?
Efferent fibers : fibers that bring info away from (the CNS), the outputs. Motor neurons control muscle contaction and gland secretion. The soma of motor neurons is located within the spinal cord (the CNS)
61
What system are the sensory neurons a part of?
the PNS
62
What are axons of sensory neurons? What does that mean? What do sesnory neurons do? Where do they send this info?
Afferent fibers: fibers that bring info towards the CNS, the inputs. Sensory neurons detect changes in the external and internal environment. They send this information to the CNS
63
How do the brain and spinal cord communicate with the rest of the body? What are these nerves a part of? What do they do?
Via nerves: cranial and spinal They are a part of the PNS They convey messages from the CNS to body's muscles and glands
64
How many pairs of spinal nerves attach to the spinal cord? How many per each vertebrae?
31 pairs. About 1.
65
How many pairs of cranial nerves attach to the ventral surface if the brain?
12 pairs
66
Do all the cranial nerves attach to the ventral surface of the brain? Exceptions?
No, the 10th serve sensory and motor functions of head and neck region doesn't, all the other cranial nerves do.
67
What is the 10th cranial nerve called? Why? What does it regulate?
It is called the vagus (wandering) nerve because its branches wander throughout the thorcic and abdominal cavities. It regulates functions of the heart, lungs, upper digestive track and other organs in the area
68
What is the spinal cord?
A long cortical structure that is approximately as thick as an adult's little finger.
69
What is the principal function of the spinal cord?
To distribute motor fibers to the effector organs of the body (glands and muscles) and to collect somatosensory information to be passed on to the brain
70
Does the spinal cord have a certain degree of autonomy?
Yes, various reflexive control circuits are located there
71
Describe the somatic nervous system
Interacts with external environment Afferent nerves: Carry sensory signal from eyes, ears, skin, etc to CNS Efferent nerves: carry motor signals from CNS to skeletal muscles
72
Describe the autonomic nervous system
Regulates body's internal environment Afferent nerves: Carry sensory signals from internal oragns to CNS Efferent nerves: carry motor signals from CNS to internal organs
73
What are the two components of the PNS?
Somatic and autonomic nervous system
74
What is the somatic nervous system?
Part of the peripheral nervous system that controls skeletal muscle movements and processes sensory information that related to the outside world. In general the somatic system interacts with the external environment.
75
What is the autonomic nervous system?
Part of the peripheral nervous system that is concerned with sensation and regulation of smooth muscle, cardiac muscle and glands. In general, interacts with the body's internal environment
76
What are the 2 components of the autonomic nervous system : efferent branch?
the sympathetic and parasympathetic division
77
What does the sympathetic division of the autonomic nervous systems efferent branch do? What does it do once stimulated?
Part of efferent autonomic nervous system that primes the body for action, in life threatening situation. Once stimulated, it shunts blood away from organs that are necessary for immediate survival and increases blood flow to organs involved in intense physical activity
78
What does the parasympathetic division of the efferent autonomic nervous system do? What is it associated with? What are its functions?
Supports activities that occur when the body is in a relaxed state and all is well. Generally involved with body's energy stores. - Feed and breed, rest and digest Functions include sexual arousal, defecation, urination and salvation
79
What do these anatomical directions mean? Anterior Posterior Superior Inferior Rostral Caudal Dorsal Ventral Lateral Medial
Anterior: In front Posterior: behind Superior: above Inferior:below Rostral: towards the beak Caudal: towards the tail Dorsal: towards the back Ventral: towards the stomach Lateral : away from midline Medial: toward midline
80
What do we do when we're dealing with anatomical directions in regards to the human spinal cord?
Rotate
81
What do these terms mean? transverse plane: medial: lateral: Sagital plane: Horizontal plane:
transverse plane: frontal/cross/coronal section medial: toward midline lateral: away from midline Sagital plane: a mid sagital cut between the eyes Horizontal plane: top of brain cut
82
What do these terms mean? contralateral: ipsilateral: superficial: deep: proximal: distal: brain nuclei:
contralateral: structures on other side of body ipsilateral:structures on same side of body superficial: located close to the surface, close to exterior of animal deep: located far away from surface, deep in the interior of the animal proximal: nearby distal: far away brain nuclei: in the brain, collection of neurons that are clustered together that all work together to serve some function

Behavioural Neuroscience (15 decks)

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