chapter 47-48-49 Flashcards

1
Q

Which of the following statements is NOT true regarding temperature regulation?
A. Temperature regulation is mediated by the hypothalamus
B. Hyperthermia may develop because of subarachnoid hemorrhage
C. Hyperthermia may trauma
D. Hyperthermia may developfrom trauma
D. Hyperthermia persists after development despite improvement in other spheres

A

d

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2
Q

Appetite is clearly under cortical and subcortical control with influences at multiple levels.
Which of the following statements is NOT true regarding control of appetite and weight?
A. Weight increase can be provoked by sight, aroma, and taste of food
B. Weight increase can be caused by lesion of the ventromedian thalamus
C. Weight increase can be caused by lesion of the dorsomedial nucleus
D. The brainstem functions in the hypothalamic control over appetite

A

c

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3
Q

Which of the following statements regarding eating disorders is true?
A. Patients with anorexia have low levels of norepinephrine
B. Patients with anorexia have low levels of serotonin
C. Patients with bulimia nervosa have enhanced secretion of cholecystokinin
D. Patients with bulimia nervosa have no measurable biochemical changes

A

a

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4
Q
Which of the following pituitary hormones are under hypothalamic control?
A. Growth hormone
B. Prolactin
C. Thyrotropin
D. Lutenizing hormone
E. All of these
A

e

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5
Q
What effect does increased production of prolactin commonly have on men?
A. Galactorrhea
B. Acromegaly
C. Impotence
D. None
A

c

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6
Q

A 10-ycar-old female child is brought in because of development of secondary sexual
characteristics. Which diagnostic studies are appropriate?
A. MRI
B. CT
C. Serum growth hormone levels
D. All of these
E. None of these

A

e

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7
Q

Prolactin levels are frequently obtained in patients with suspected seizures. Which of the
following statements are true regarding the use of prolactin to differentiate seizures from nonepileptic
events?
A. Prolactin is elevated in patients with generalized tonic-clonic seizures
B. Prolactin is not elevated in patients with simple partial seizures
C. Prolactin elevation in the morning is normal
D. Prolactin elevation is short-lived after a seizure
E. All are true

A

e

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8
Q

Which of the following statements are true regarding pituitary apoplexy?

  1. Patients may have the clinical presentation of subarachnoid hemorrhage
  2. Cause may be pituitary infarction
  3. Cause may be pituitary hemorrhage
  4. Diagnosis is usually missed on CT
A

a

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9
Q

Which of the following statements are true regarding evaluation of Cushing’s syndrome?
1. Dexamethasone suppression test is important to diagnosis of Cushing’s syndrome
2. Administration of dexamethasone normally results in increased urinary excretion of 17-
ketogenic steroids and urinary-free Cortisol
3. Failure to suppress Cortisol production with dexamethasone with immeasurable ACTH levels
suggests adenoma or carcinoma of the adrenal
4. ACTH levels in Cushing’s disease are markedly suppressed

A

b

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10
Q

Which of die following statements are true regarding gonadotropin-secreting tumors?

  1. Most gonadotropin-secreting tumors produce LH
  2. Some tumors produce both LH and FSH
  3. Gonadotropin-secreting tumors result in patients who are hypergonadal
  4. Patients with LH-secreting tumors have increased testosterone or estradiol levels
A

c

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11
Q

A 56-year-old man has a cardiac arresi and suffers severe anoxic encephalopathy. There is some
brainstem function, but he never regains consciousness and is dependent on ventilator and
tube feedings. He does not have an advanced directive. The family wants the life supports
removed. Which is the appropriate medical approach?
A. Consult the Ethics committee
B. Disconnect the life supports
C. Continue the life supports
D. Perform EEG for determination of cerebral death.
E. Have a court-appointed attorney make a substituted judgment

A

b

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12
Q

Intractable pain from a peripheral nerve lesion would likely be managed best by which of the
following approaches?
1. Tricyclic antidepressants
2. Anticonvulsants
3. SSRIs
4. Controlled doses of sustained-release narcotics

A

a

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13
Q

Increased exercise is helpful to augment strength for which of the following conditions?

  1. Hereditary neuropathy
  2. ALS
  3. Parkinson’s disease
  4. Myasthenia gravis
A

a

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14
Q

A 58-year-old man with advanced ALS has elected to forego intubation and other means of
ventilatory support. When Iris ventilatory failure is imminent and he sutfers from the anxiety of
air hunger, which is the best treatment strategy?
A. Intubate and ventilate despite the patient’s wishes
B. Use supportive care only. No sedatives are given because they may-hasten death
C. Use morphine or other sedative to lessen the anxiety and promote comfort even though it
can hasten death
D. Consult the Ethics Committee

A

c

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15
Q

A 25-year-old woman presents with her 4-year-old child, asking him to be tested for
Huntington’s disease. Her rather has clearly documented Huntington’s disease, but no one else
in the family was known to be affected. Which clinical formulation would be the best?
A. Since no one else was affected, the woman’s father had a sporadic occurrence and will not
pass it to his children. There is no need to test the woman or her child.
B. Testing the child would have implications for the mother as well. Genetic and psychologic
counseling prior to a decision on testing is indicated.
C. It is the obligation of the physician to test regardless of the implications, so the examination
should be performed at once.

A

b

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16
Q

A 56-year-old man with progressive weakness has corticospinal tract signs and widespread
denervation on EMG. The diagnosis of ALS is made. Which is the most appropriate counseling
regarding prognosis and outcome?
A. The patient can expect to expire within three years and there is no hope for stabilization or
improvement.
B. Many patients with ALS stabilize and improve.
C. Most patients with ALS show gradual progression of the symptoms, but stabilization can occur.
D. AI S is a diagnosis only made with certainty at autopsy, so we cannot predict the prognosis of
the patient.

A

c

17
Q

Which of the following statements regarding GABA and its receptors are true?
1. GABA is mainly inhibitory
2. Benzodiazepines bind to GABA receptors
3. Barbiturates bind to GABA receptors
4. Baclofen binds to GABA receptors
Select: A = 1.2, 3. B - 1, 3. C - 2,4, D = 4 only. E = All

A

e

18
Q

Which of the following statements are true regarding glutamate and aspartate?

  1. Glutamate is the most prevalent excitatory neurotransmitter
  2. Carbamazepine blocks some glutamate receptors
  3. Excess release of glutamate causes neuronal degeneration
  4. Aspartate is the main transmitter for neuronal projections from the brainstem to the spinal cord
A

a

19
Q

Which of the following statements are true regarding acetylcholine receptors?
1. Sympathetic ganglion receptors are nicotinic
2. Motor endplate receptors are muscarinic
3. Patients with myasthenia have increased acetylcholine receptor turnover causing fewer
receptors to be available for binding with acetylcholine
4. Botulinum toxin blocks binding of acetylcholine to the post-synaptic receptors
Select: A = 1, 2, 3. B = I, 3. C = 2, 4. D = 4 only. E = All

A

b

20
Q

Which of the following agents are acetylcholinesterase inhibitors?
1. Edrophonium
2. Tacrine
3. Pyridostigmine
4. Donepezil
Select: A = 1. 2, 3. B = 1, 3. C = 2, 4. D = 4 only. E - All

A

e

21
Q

Glutamate and NMDA receptors are involved in which of the following conditions?

  1. Memory
  2. Neonatal glycine encephalopathy
  3. Stroke
  4. Migraine
A

e

22
Q
Parkinsonian symptoms would be produced by a drug which binds to which subset of the
dopamine receptor ?
A. Dl
B. D2
C. D3
D. D4
A

b

23
Q

Which of the following statements regarding the phramocology of dopamine in the brain ?

  1. Metabolised by MAO-A
  2. Metabolized by COM1
  3. The action of dopamine is ended by enzymatic degradation at the receptor
  4. Resorpin depletes dopamine by preventing reuptake into storage vesicles
A

c

24
Q

Which of the following statements are true regarding serotonin action and metabolism?
1. Migrant’ headache is preceded by increased free plasma 5-HT
2. Serotonin is a precursor of melatonin
3. Psychotic features of LSD exposure are thought to be due to binding to the 5-1 -IT2 receptors.
4. Sumatriptan activates the 5-HT1 D receptors
Select: A - 1.2, 3. B -1,3. C = 2.4. D = 4 only. E = All

A

e

25
Q

Opioid peptides have been shown to have roles in which of the following?

  1. Seizures
  2. Exercise
  3. Pain
  4. Drug abuse
A

e

26
Q

Which of the following statements is true -regarding the role of substance P in nociceptive
pathways?
A. Substance P is an inhibitory transmitter in the spinal coid, closing the gate to nociceptive
transmission
B. Substance P is produced by the motor neurons and sensitized afferent fibers to nociceptive
input
C. Substance P is a transmitter in the pain pathways of the dorsal horn of the spinal cord
D. Substance P functions in central nociceptive pathways of the brain, and not the spinal cord

A

c