Chapter 45 - Men's Health

Question 1

Androgen

-Testosterone

Answer 1

 Testosterone
 MOA: Comparable to endogenous testosterone; stimulates cellular synthesis of protein
 Use: Androgen deficiency states (hypogonadism)
• Usually administered as a gel, be cautious about being around women, kids, etc. so they do not have close contact and spread hormone
 AE: Acne, changes in sex drive, hair loss, headache, mouth irritation/gum tenderness, edema, masculinization. In women: hirsutism, deepening of voice, menstrual irregularities

Question 2

Phosphodiesterase-5 Inhibitor

• sildenafil (Viagra)

Answer 2

 sildenafil (Viagra)
 MOA: Relaxes smooth muscle in corpus cavernosum
• Blocks enzyme Phosphodiesterase-5
• Allows increased blood flow into penis
 Use: To treat erectile dysfunction
 AE: Most serious is hypotension; headache, dizziness, flushing, rash; nasal congestion, diarrhea, dyspepsia; UTI, chest pain, indigestion;
 Priapism – undesired erection (longer than 4 hours) –> need to go to ER

Question 3

5-alpha-reductase Inhibitors

• finasteride (Proscar)

Answer 3

 finasteride (Proscar)
 MOA: Inhibits 5-alpha reductase
 Uses: Promotes shrinkage of enlarged prostate gland
• Also prescribed to promote hair regrowth
 AE: Sexual dysfunction; impotence, diminished libido, ejaculatory dysfunction

Question 4

Alpha1 Adrenergic Blocker

• tamsulosin (Flomax)

Answer 4

 tamsulosin (Flomax)
 MOA: Relaxes the muscles in the prostate and bladder neck, enhancing ability to urinate
 Use: BPH
 AE: Postural hypotension, weakness, sleepiness, difficulty falling or staying asleep, stuffy or runny nose, sore throat, blurred vision. May also cause abnormal ejaculation