Chapter 43 Flashcards

1
Q

2 types of immunity

A

Innate and Acquired

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2
Q

Immune system

A

recognizes foreign bodies and responds with the production of immune cells and proteins

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3
Q

Both invertebrates and vertebrates depend on ______ to ______

A

Innate immunity

fight infection

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4
Q

vertebrates have an additional immune defense known as _____?

A

acquired immunity

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5
Q

Innate Immunty

A

present before any exposure to pathogens
effective from the time of birth
rapid response

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6
Q

innate immunity consists of:

A

external barriers plus internal cellular and chemical defenses

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7
Q

where is innate immunity found in

A

all classes of plants and animal life

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8
Q

acquired immunity

A

develops after exposure to agents such as microbes, toxins, or foreign substances
slow response but very specific

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9
Q

Acquired immunity is found in…

A

vertebrates

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10
Q

first barrier of pathogens in insects

A

exoskeleton made of chitin

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11
Q

innate defenses of invertebrates

A

low pH
antimicrobial peptides
phagocytosis in which an enzyme lysozyme digests microbial cell walls

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12
Q

how does the immune system recognize bacteria and fungi?

A

by structures on their cell walls

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13
Q

immune response depends on?

A

the class of pathogens encountered

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14
Q

innate defenses of vertebrates

A

barrier defenses
low pH
phagocytosis
antimicrobial peptides

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15
Q

additional defenses unique to vertebrates

A

the innate defenses with WBC
Inflammatory response
NK cells

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16
Q

barrier defenses of vertebrates

A

skin

mucous membranes of respiratory, urinary, and reproductive tracts

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17
Q

mucus

A

traps and allows for the removal of microbes

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18
Q

body fluids hostile to microbes

A

saliva
mucus
tears

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19
Q

the low pH of skin and digestive system prevents what?

A

growth of microbes

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20
Q

white blood cells

A

(luekocytes)
engulf pathogens in the body
then fuses with a lysozyme to destroy the microbes

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21
Q

macrophages

A

produced by differentiation of monocytes

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22
Q

Inflammatory response

A

following an injury. mast cells release histamine which changes increase local blood supply and allow more phagocytes and antimicrobial proteins to enter tissues

23
Q

histamine

A

promotes changes in blood vessels

24
Q

what accumulates at the site of inflammation?

A

fluid rich in white blood cells, dead microbes, and cell debris

25
all cells in the body (except red bloods cells) have....
a class 1 MHC protein on their surface
26
what type of cells no longer express MHC proteins?
cancerous and infected cells
27
what happens to cancerous or infected cells?
natural killer (NK) cells attack them
28
inflamation can be either...
local or systemic (throughout the body)
29
Fever is...
a systemic inflammatory response triggered by pyrogens released by toxins from pathogens
30
how do some pathogens avoid destruction?
by modifying their surface
31
why do pathogens modify their surface?
to prevent recognition or by resisting breakdown following phagocytosis
32
lymphocytes
a type of white blood cell that recognizes and responds to antigens
33
T cells
lymphocytes that mature in the thymus above the heart
34
B cells
lymphocytes that mature in bone marrow
35
lymphocytes contribute to...
immunological memory
36
immunological memory
an enhanced response to a foreign molecules encountered previously
37
each individual lymphocyte is specialized to...
recognize a specific type of molecules
38
2 types of acquired immunity
Humoral immune response | Cell mediated immune response
39
humoral immune response
B cells after recognizing an antigen give rise to plasma cells which secrete antibodies or immunoglobulins
40
Antibodies or immunoglobulins
proteins secreted by plasma cells
41
Cell mediated immune response
T cells bind to antigen fragments and then activate macrophages, natural killer cells and antigen specific cytotoxic T cells
42
3 important properties of the acquired immune system
receptor diversity a lack of reactivity against host cells immunological memory
43
primary immune response
first exposure to a specific antigen
44
during the primary immune response...
effector B cells called plasma cells are generated | T cells are activated to their effector forms
45
secondary immune response
memory cells facilitate a faster, more efficient response
46
active immunity
develops naturally in response to an infection
47
passive immunity
provides immediate, short-term protection
48
Passive immunity is passed along naturally when...
IgG crosses the placenta from mother to fetus or when IgA passes from mother to infant in breast milk
49
when immune system is disrupted
autoimmune disease allergy immunodeficiency
50
autoimmune disease
the immune system loses tolerance for self and turns against certain molecules of the body
51
autoimmune diseases include:
rheumatoid arthritis insulin-dependent diabetes mellitus multiple sclerosis
52
allergies
exaggerated (hypersensitive) responses to antigens called allergens
53
inborn immunodeficiency
results from hereditary or developmental defects that prevent proper functioning of innate, humoral, and/or cell-mediated defenses
54
acquired immunodeficiency
results from exposure to chemical and biological agents