CHAPTER 42 – ANTINEOPLASTIC AGENTS AND ADJUNCTS

Question 1

Although some anti-cancer drugs share common adverse effects, the overall adverse effect profile will depend on the combination of the drugs used. Mr DG, a 65 year old man, had been diagnosed with gastric cancer, and will be treated using the ECX protocol (epirubin, cisplatin and capecitabine (Xeloda)).

Answer 1

Although some anti-cancer drugs share common adverse effects, the overall adverse effect profile will depend on the combination of the drugs used. Mr DG, a 65 year old man, had been diagnosed with gastric cancer, and will be treated using the ECX protocol (epirubin, cisplatin and capecitabine (Xeloda)).

Question 2

1. List the common adverse effects that Mr DG should be alerted to.

Answer 2

• Prone to infections
• Brushing more easily
• Fatigue
• Diarrhoea
• Soreness
• Change in heart rhythm
• Kidney damage
• Loss of fertility

Question 3

How do the serious adverse effects of these drugs compare to those observed with Tyrosine kinase inhibitors (which are not cytotoxic agents)?

Answer 3

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Question 4

3. What pharmacological treatments are available for the treatment of the adverse effects of antineoplastic drugs?

Answer 4

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