CHAPTER 39 – DRUGS AFFECTING THE MALE REPRODUCTIVE SYSTEM

Question 1

Mr CD returned a week later and was advised that his urinalysis dos not indicate an infection or the presence of blood. The PSA result was normal and the GP concluded that Mr CD had benign prostatic hyperplasia (BPH). In view of the obvious impact on the quality of life of Mr CD, the GP commenced treatment with the combination drug Dutasteride and Tamsulosin, once capsule daily. Mr CD was advised to take the drug approximately 30 minutes after eating a meal.

Answer 1

Mr CD returned a week later and was advised that his urinalysis dos not indicate an infection or the presence of blood. The PSA result was normal and the GP concluded that Mr CD had benign prostatic hyperplasia (BPH). In view of the obvious impact on the quality of life of Mr CD, the GP commenced treatment with the combination drug Dutasteride and Tamsulosin, once capsule daily. Mr CD was advised to take the drug approximately 30 minutes after eating a meal.

Question 2

1. Explain why the GP ordered a PSA test

Answer 2

The GP has ordered a Protstate specific antigen test (PSA) as due to his age the chances of him having a BPH would be high however it is best to check whether the there is any chance that he may have cancer. As well as to eliminate the chances of bacteriuria already being present

Question 3

2. Discuss the mechanism of action of Dutasteride and Tamsulosin. And their beneficial effects in the treatment of BPH.

Answer 3

Dutasteride is a 5a-reductase inhibitor but is less specific for the prostate enzyme.
Tamsulosin is an alpha-adrenoceptor agonist which can have long term trophic effects on smooth muscle.
-should allow him to urinate more easily.
-help reduce/prevent the growth of the prostate

Question 4

3. Why has Mr CD been advised to take the drug 30 minutes after a meal?

Answer 4

To ensure that the levels of the drug are given to allow for even distribution of the drug is met.