Chapter 4 - Proteins Flashcards

1
Q

What are the building blocks of proteins?

A

amino acids

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2
Q

What are dispensable amino acids?

A

body makes these from other amino acids

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3
Q

What are indispensable amino acids?

A

the body can’t make these; needed to obtain from the diet

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4
Q

What are conditionally dispensable amino acids?

A

we can usually makes these, but sometimes some physiological conditions render us unable

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5
Q

Why is tyrosine a conditionally indispensable amino acid for individuals with PKU?

A

people with PKU lack the enzyme to turn phenylalanine into tyrosine

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6
Q

Which chemical element do proteins contain and provide to the body that fats and carbohydrates can’t?

A

nitrogen

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7
Q

What is deamination?

A

the removal of the amine group from an amino acid so it can be broken down for use

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8
Q

What does nitrogen balance measure?

A

nitrogen balance measures the intake to output of nitrogen which reflects protein status in the body

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9
Q

What does it mean if someone is in zero nitrogen balance?

A

the body is balancing nitrogen mass without loss or gain of nitrogen

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10
Q

What does it mean to be in positive nitrogen balance?

A

you have a greater intake than output of nitrogen

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11
Q

Who do we see positive nitrogen balance in?

A

people recovering from surgery/trauma/illness or those in growth and devlopment

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12
Q

What is negative nitrogen balance?

A

nitrogen output is greater than intake

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13
Q

What can cause negative nitrogen balance?

A

inadequate protein intake, or due to burns, trauma, surgery, or old age

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14
Q

What are the five functions of proteins?

A

tissue building, water and pH balance, energy, metabolism and transportation, and immune system

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15
Q

Why is protein important in tissue building?

A

protein makes up our organs, skin, hair, and nails

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16
Q

How do proteins affect water and pH balance?

A

via oncotic (pulling) pressure exerted by albumin (protein), and a unique surface structure that allows them to act as buffers that resist pH changes

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17
Q

How does protein get used for energy? Under what conditions?

A

we use protein as a very last resort, some amino acids can be made into glucose gluconeogenesis and other to acetyl coA to enter the citric acid cycle

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18
Q

How do proteins help manage metabolism and transportation?

A

digestive enzymes like salivary amylase, proteases, and pancreatic lipase control metabolic processes; some proteins carry nutrients (lipoproteins carry fats)

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19
Q

How do proteins influence the immune system?

A

a compromised immune system is a sign of protein deficiency; lymphocytes and antibodies are types of proteins

20
Q

What is a complete protein food?

A

a food containing all the amino acids in a sufficient quantity

21
Q

What is an incomplete protein food?

A

food that lacks or is deficient in 1 or more amino acid

22
Q

What are some complete protein food sources?

A

meat, dairy, egg yolks (most animal sources)

23
Q

What two plant foods are complete protein sources?

A

quinoa and soy

24
Q

What are complementary proteins? List some examples

A

pairing plant proteins to get all amino acids
legumes + grain, legumes + nuts/seeds

25
What are the DRIs for protein?
10-35% of your total calorie intake; recommend 0.8 g of protein per kg body weight a day of relatively inactive (if more active increase this)
26
What protein digestion happens in the mouth?
mechanical (mastication)
27
What protein digestion happens in the stomach?
mechanical (peristalsis) and chemical (HCL, pepsin/rennin)
28
What protein digestion happens in the small intestine?
mechanical (peristalsis) and chemical (trypsin, chymotrypsin, carboxypeptidase, aminopeptidase, dipeptidase)
29
What organs secrete which proenzymes into the stomach?
the liver secretes zymogens and pepsinogen
30
What are the active enzymes in the stomach?
proteases from the liver and HCl and pepsin (rennin in babies) from the stomach
31
What does hydrochloric acid (HCl) do?
unfolds and breaks down proteins
32
What does pepsin do?
splits large protein chains into smaller amino acid chains
33
What does rennin do?
aids in milk digestion via coagulating it to slow digestion down
34
What are the proenzymes in the small intestine? Which organs secrete them?
the pancreas secretes trypsinogen, chymotrypsinogen, and procarboxypeptidase; the small intestine secretes aminopeptidase and dipeptidases
35
What does trypsin do?
breaks long chains into smaller peptides
36
What does chymotrypsinogen do?
continues protein breakdown process
37
What does carboxypeptidase do?
attack carboxyl end of protein to produce small peptides and free amino acids
38
What does aminopeptidase do?
attacks nitrogen end to free one amino acid at a time
39
What do dipeptidases do?
they are the final enzyme that break dipeptides releasing two amino acids
40
What activates pepsinogen?
hydrochloric acid (HCl)
41
What activates trypsin?
enterokinase
42
What activates chymotrypsin?
trypsin
43
What activates carboxypeptidase?
trypsin
44
What are the active enzymes in the small intestine?
trypsin, chymotrypsin, carboxypeptidase, aminopeptidase, dipeptidase
45
Do amino acids directly enter the general blood circulation from the intestine? Why or why not?
no, they go to the hepatic portal system first so the liver can determine if/where they are needed