CHAPTER 4: CNS: Nausea Flashcards
Which class of antiemetics is valuable for treating N&V associated with; neoplastic disease, radiation or emesis caused by drugs (e.g) opioids
Phenothiazines
What is a side effect of phenothiazines?
Severe dystonic reactions - dopamine antagonists
Which class of antiemetics is used to treat N&V associated with terminal illness?
Antipsychotics - haloperidol and levomepromazine
Related to phenothiazines, which class of antiemetics is useful in gastroduodenals, hepatitis and billiary disease causing N&V?
Metoclopramide
Metoclopramide and phenothiazines are contra-indicated in N&V in patients with Parkinson’s disease. Which drug can be used as it does not cross the BBB?
Domeperidone
Which class of antiemetic is valuable in management of N&V in patients receiving cytotoxics or PONV?
5-HT3 antagonists
Give an example of a 5-HT3 antagonist
Ondansetron
Aprepitant is an NK-1 inhibitor licensed for acute and delayed N&V associated with what?
Cisplatine-based chemotherapy
Which other drugs is aprepitant usually given with? (2)
- Dexamethasone
2. Ondansetron
Which synthetic cannabinoid may be used for N&V caused by cytotoxic chemotherapy unresponsive to conventional anti-emetics?
Nabilone
If severe, which antiemetic can be used for vomiting during pregnancy?
Promethazine
What are the alternatives to promethazine for vomiting during pregnancy?
- Prochlorperazine
2. Metoclopramide
What is a more serious condition that stems from N&V in pregnancy?
Hyperemesis gravidarum
How is hyperemesis gravidarum treated? (4)
- IV fluids
- electrolyte replacement
- anti-emetics
- nutritional support
Which classes of drug are used for PONV? (4)
- Antihistamines
- 5HT3 antagonists
- Dexamethasone
- Prochlorperazine