Chapter 4- Cell Membrane Flashcards
describe the structure of phospholipids
Their heads face the water as they are polar while their tails face out of the water as they are non-polar
describe the structure of a cell membrane/ features of the fluid mosaic model
- they are a bilayer of phospholipids
- They have proteins that are either polar or non-polar
- the phospholipid tails point inwards which forms a hydrophobic interior while head faces outwards
- proteins are found in the inner layer, outer layer or span along the whole membrane
- Most float and some are fixed
- many proteins are either glycoproteins or glycolipids
- molecules of cholesterol are found as well
- some phospholipid tails are saturated and unsaturated. The more saturated they are the longer the tails, hence, the less fluid the membrane is
why are cell membranes described as a fluid mosaic model
Fluid: both the phospholipids and proteins can move about and have a fluidity nature. phospholipids can move sideways while proteins can move within.
Mosaic: This is due to the scattered arrangement of proteins within the bilayer
what is the role of phospholipids in the cell membrane
these contain a lipid bilayer and can control what substances enter and what cannot leave based on their polarity
They can also act as signalling molecules
what are the roles of cholesterols in the cell membrane
-Maintains mechanical stability by getting in between the phospholipids to reduce fluidity
-can prevent polar molecules from passing through
-maintaining the correct fluidity at different temperature
>Cold temperatures: Avoid the phospholipids from packing close together
>High temps: decreasing the fluidity
what are glycoproteins and glycolipids
proteins or lipids are attached to a short carbohydrate chain which project like antenna into the water and can create hydrogen bonds to stabilise the membrane structure
What are the roles of glycoproteins and glycolipids and proteins in the cell membrane
1-Can act as receptor molecules
2-Cell to cell recognition
3-Transport proteins
4-Enzymes
5-Cytoskeleton
what do glycoproteins/lipids act as when it comes to cell recognition
They act as cell markers and are cell surface antigens. All cells have their own type of antigen
what are the 2 types of transport proteins, and what do they have that allows polar molecules to pass through
They have hydrophilic channels for polar molecules.
carrier and channel proteins
what is cell signalling
A molecular mechanism by which cells detect and respond to external stimuli including communication between cells
outline the 3 main steps taken in cell signalling
1) there’s the secretion of chemicals called ligands
2)these are transported to the target cells
3)These ligands bind to the cell surface receptors
how do receptors attach to the ligand
They are specific to the ligand
What is a transduction
The conversion of the original signal from one method of transmission to another
outline the typical signalling pathway
-the signal arrives at a protein receptor in a cell surface membrane
-The receptor is able to recognise this signal.
- the signal brings about a change to the receptors shape
-cell transduction occurs whereby the receptor can interact with the next component of the pathway
How is a second messenger introduced
- This is stimulated by a G protein.
- several second messengers can be released in response to only one receptor being stimulated
- This can represent an AMPLIFICATION of the original signal
How does the second messenger operate
These activate enzymes which further activate more enzymes which bring about a required change in cell metabolism
What is the name of the sequence of events triggered by the G protein
Signalling Cascade.
What are 3 alternative ways a receptor can alter cell activity
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- Opening an ion channel resulting into a change in membrane potential
- act directly as a membrane bound enzyme
- Acts as an intracellular receptor
what different mechanisms may occur for movement into and out of the cell
-Osmosis
-simple diffusion
-facilitated diffusion
-Bulk processes
-active transport