Chapter 4: Back and Embryology Flashcards
What is the period of time called when all three germ layers are present?
gastrulation
What are the three primary germ layers?
ectoderm, endoderm, mesoderm
What are the two initial germ layers?
hypoblast: cells that develop in the first weekepiblast: cells that develop in the second week
Where do the head and brain eventually develop?
the primitive groove
What do neural crest cells develop into?
ganglia, medulla, facial bones
What do somites develop into?
vertebrae
What’s the importance of the notochord?
initiates neuralation (the development of neural tissue)
What germ layer does the spinal cord develop from?
ectoderm
What do the parietal and visceral mesoderm layers differentiate into?
layers surrounding the heart and lung
What serves as a rigid axis for the embryo?
notochord
In what week does the development of upper and lower limb buds occur?
4th week
The upper limb undergoes what rotation? Lower limb? Where are their extensors found?
upper = external rotation; extensors are posteriorlower = internal rotation: extensors are anterior
What exact germ layer are the somites formed from?
pariaxial mesoderm
What all do the somites form? Where are they found on an embryo?
skull, dermis, vertebral bodies, skeletal muscle; found on the dorsal surface of the embryo
At what week are all three germ layers present?
3rd week
What rises up to create the neural groove and later the neural tube?
ectoderm
How many somites are there for each portion of the body? (occipital, cervical, thoracic, etc.)
4 occipital8 cervical12 thoracic5 lumbar5 sacral8-10 coccygeal
Which areas of the somites fuse together?
sacrum, coccyx, and occipital bones all fuse respectively
The embryo is the size of the tip of an eraser at the end of which week?
week 3
Explain the differences between the superior half of the somite and the inferior half; which structures are formed in each?
superior: less dense, so spinal nerves and IVD developed hereinferior: more dense, so bony vertebrae are formed
When is the heart bulge first visable?
4th week
How do the disks form?
notochord pinches off, gets squeezed out and forms the nucleus puposis and anulus fibrosis.
T/F: The notochord is still present at birth.
true
What structure forms the IVD?
notochord
Why/how does the notochord get squeezed?
Because the somites are developing, so the notochord has is squeezed and becomes the IVD
What does the somitic mesenchyme consist of?
cranial, less dense portion (nerves and IVD)caudal, more dense portion (vertebrae)
T/F: You can tell what day of development the embryo is on by counting the number of somites.
true
In what week is the spine in place?
5th week
What happens in spinal stenosis? Why does this occur?
Both the vertebral foramen and the intervertebral foramen have the potential to narrow; happens naturally with age, but could also be genetics or poor posture
What causes spina bifida? Why does this range in severity?
- the neural groove not fully closing to form the neural tube causes spina bifida- but this can range in severity: if only the bony structure is impaired the spinal cord/meninges are fine. If the tube is more deformed and the spinal cord/meninges are impaired, then you have lots of developmental delays and disabilities
The muscles of the trunk are formed from what germ layer?
paraxial mesoderm
All of the skeleton except for the skull is formed from what germ layer?
paraxial mesoderm
The urogenital system is formed from what germ layer?
intermediate mesoderm
What are the three primary centers of ossification?
one in each neural arch, and one in the centrum (body)
What is the direction of ossification throughout the vertebral column?
develop in cervical/thoracic first, then move more cervical, then go down to thoracic/lumbar
When do these primary ossification sites form on the vertebrae?
4th-12th week gestation
T/F: The improper lining up of the joints (ie. superior and articular facets) can be a source of back pain.
true
What parts of the body does the intermediate mesoderm form?
kidneys and relating ducts, reproductive organs
What are the two distinctions of lateral plate mesoderm?
1) somatic (parietal mesoderm)2) splanchnic (visceral mesoderm)
At what age do the primary centers of ossification unite and fuse?
by 3-5 years old
What does the paraxial mesoderm form?
somites, skeleton, muscles of the extremity and trunk, vertebral column, dermatomes, and dermis
Where are myotomes and dermatomes first formed?
on the somites
What germ layer forms the liver and pancreas? (GI tract)
endoderm
What germ layer forms appendicular skeleton?
mesoderm
What germ layer forms the neural tube?
ectoderm
What germ layer forms the hair, sebaceous glands, and sweat glands?
ectoderm
What germ layer forms the heart?
mesoderm
What germ layer forms the dermatomes?
mesoderm, because they’re from somites
What germ layer forms the spinal cord and brain?
ectoderm
What week does neuralation take place?
week 4
What week do somites start to form?
week 4
What are spinal ganglion?
- clusters of dorsal sensory nerves, usually in the IVF- cell bodies of the dorsal roots
What are the 3 meninges?
pia, dura, arachnoid
What’s worse, a severed dermatome or peripheral nerve?
dermatome: lose input to all those regions
A patient reports severe whiplash coming in from an accident. Before treating, what should you make sure isn’t torn?
alar and transverse ligaments
What is the fine filament of connective tissue at the end of the conus medularis? What’s it for?
filum terminale, an extension of the pia that anchors the spinal cord to the coccyx
How far does the conus medularis extend to?
L1-L2
What does the notochord develop from?
The primitive node
What is the primitive streak?
indentation along the surface of the embryo; on caudal end is the primitive node
The vertebral artery becomes what artery when it goes up to the head?
basilar artery
What does the basilar artery supply?
the posterior half of the brain
Why is the proximal part of the vertebral artery prone to compression?
due to the longus colli and scalene muscles
Why do the transverse processes of C2-C6 cause the vertebral artery to be prone to compression?
compression from osteophytes and subluxed facet joints
What is an osteophyte?
a bone spur, indicating degeneration of the spine; common with age
Why is the suboccipital region prone to compression with the vertebral artery?
prone to compression from cervical rotation
What area of the vertebral artery trail is prone to plaque and stenosis build up?
intercranial portion
How many zygapophyseal joints are in the cervical spine?
14
How many uncovertebral joints are in the c-spine?
10
What is unique about the zygaphophyseal joint?
- each dorsal rami innervates two adjacent joints, so each joint has two dorsal rami innervating it-It has dual innervation; one from the sinovertebral artery and one from the medial branch of dorsal rami. This gives the joint ability to be a spot of pain
Which muscles attach to the nuchal ligament?
rhomboid minor, trapezius, serratus posterior superior, splenious
What ligament limits flexion in the C-spine and assists in posture?
ligamentum nuchae
Which vertebrae has a “vertebrae prominens”
C7
Which area of the vertebral artery is prone to compression via bone spurs or subluxed facet joints?
transverse C2-C6 portion
Where are the facet joints most likely to dislocate?
In C-spine b/c they’re more horizontal; allows for greater range of motion but more likely for dislocation
What is unique about the joints of luschka? How do they form?
- it’s “not a real joint” b/c it’s not present at birth- forms from the weight of the C-spine being distributed
Where can there be plaque build up and stenosis along the vertebral artery pathway?
intercranial portion
Which part of the vertebral artery is prone to compression via the surrounding muscles, like scalene and longus colli?
proximal portion
What joint allows rotation of C-spine?
atlantoaxial joint
T/F: There is no spinous process on C1.
true
What direction are the zygapophyseal joints facing in the C-spine?
anterior and inferior, vs posterior and superior like most other areas of the spine
What do articular pillars do?
- help with stability of C-spine; they’re the column arrangements of the facet joints, junction of the pedicle and the lamina- this is what you palpate when you feel the C-spine usually
Do the uncinate joints have synovial membranes?
yes
What’s the role of the uncovertebral joint? (4)
1) limits lateral flexion of c-spine2) guides cervical flexion/extention3) prevents posterior translation of neighboring verts4) supports the IVD
Which portion of the spine forms the kyphotic curve?
thoracic spine
What forms the IVD?
notochord
What are the 5 secondary sites of ossification?
- Two on the annular epiphysis (body), one anterior and one posterior- two on the tips of the transverse processes- one on the tip of the spinous process
What structure initiates the development of neural tissue?
Notochord
Where does the notochord develop?
In the primitive node
What are the primary curvatures of the spine?
thoracic and sacral; concave anterior
What are the secondary curvatures of the spine?
cervical and lumbar; concave posterior
What helps the spine to handle compressive forces?
the curvatures of the spine
Where does the transverse ligament of the atlas attach?
between the bodies of the lateral masses of C1
Where does the alar ligament attach?
From the sides of the dens to the foramen magnum
T/F: T-spine is pretty unstable because of all the rib attachments
false; very stable so not much herniation of disks
Does the spinal cord get larger or smaller as it travels to the lumbar region?
Larger
What movements do the lumbar vertebrae favor?
extension/flexion, very little rotation in this area