Chapter 33 - Drugs for Headache Flashcards
What drugs are used to abort an ongoing headache attack?
-NSAIDs
-ASA-like drugs
-opioid analgesics (ie codeine)
-migraine specific drugs (ie. triptans, serotonin agonists, ergot alkaloids)
What drugs are used to prevent headache attacks from occurring?
-beta blockers
-tricyclic antidepressants
-antiseizure drugs (ie topiramate and divalproex)
-CCBs
-botox
-estrogen
-humanized IgG4 monoclonal antibody
Which migraine form is more common?
migraine without aura
What precedes migraines with aura?
visual or auditory symptoms
What is the pathophysiology behind migraines?
a neurovascular disorder that involves the dilation and inflammation of intracranial blood vessels
What causes the pain from migraines?
vasodilation
What kind of drug is Sumatriptan?
serotonin 1B/1D receptor agonist - TRIPTANS
How does sumatriptan act?
binds to 5-HT 1B/1D receptors in intracranial blood vessels and causes vasoconstriction
How is sumatriptan administered?
oral or intranasal (some oral dissolving or SubQ)
What are the adverse effects of sumatriptan?
-heavy arms
-chest pressure
-angina
-teratogenic
-vertigo
-malaise
-fatigue
-tingling sensation
-nausea
-bad taste (intranasal)
Who shouldn’t use sumatriptan?
clients with CAD, angina, or uncontrolled hypertension
What does sumatriptan interact with?
-other serotonergic drugs (SEROTONIN STORM)
When is oral sumatriptan taken?
at first sign of migraine symptoms - take another dose if no results after 2 hours 2 doses to start is more effective
Do you prime nasal sumatriptan?
NO
How is nasal sumatriptan taken?
-first sign of migraine
-blow nose, spray, mouth breathe
