Chapter 23 (Optional) - Intro to CNS Pharmacology

Question 1

Where do CNS drugs act?

Answer 1

brain and spinal cord

Question 2

Medical applications for CNS drugs:

Answer 2

-pain relief
-seizure suppression
-anesthesia
-antipsychotics

Question 3

Non-medical uses for CNS drugs:

Answer 3

-stimulant
-depressant
-euphoric

Question 4

How many neurotransmitters does the CNS have (compared to the PNS 3)?

Answer 4

21+ (like vegas)

Question 5

What impedes entry of drugs into the brain?

Answer 5

the blood brain barrier

Question 6

What can pass the blood brain barrier?

Answer 6

lipid soluble agents and drugs that cross via transport systems

Question 7

What drugs can’t cross the BBB?

Answer 7

-protein bound drugs
-highly ionized drugs

Question 8

Why are infants more sensitive to CNS drugs?

Answer 8

BBB is not fully developed

Question 9

Why is the response altered in chronic CNS drug use?

Answer 9

-brain adapts to changes which alter SE and TE

Question 10

Why are antipsychotics and antidepressants taken for weeks before effects develop?

Answer 10

responses result from adaptive changes not direct drug effects

Question 11

Tolerance

Answer 11

decreased response occurring in the course of prolonged drug use

Question 12

Physical Dependence

Answer 12

a state in which abrupt discontinuation of drug use will precipitate a withdrawal syndrome

Question 13

Withdrawal symptoms result from:

Answer 13

changes in adaptation