Chapter 3-Energy Transformation and Metabolism Flashcards
Movement of ATP from one compound to another so that it can be used.
Energy transfer
Principles that govern energy exchange, including heat exchange and the performance of work.
Laws of thermodynamics
Liver cell
Hepatocyte
Muscle cell
Myocyte
Fat cell
Adipocyte
Composed of ATP and phosphocreatine, this system replenishes oxygen rapidly without the use of oxygen.
ATP/PCr system
Isoenzyme found in muscle and brain tissue that catalyzes the formation of ATP; higher after tissue injury.
Creatine Kinase
Nitrogenous substance, derived from arginine, glycine and methionine, found in muscle tissue.
Creatine
Compound of creatine (Cr) and phosphoric acid (P) found in muscle.
Phosphocreatine (PCR)
Process of breaking down glucose for energy; can be fast or slow
Glycolytic system
Salt of pyruvic acid; the end product of glycolysis
Pyruvate
Reduced form of NAD; used to transfer electrons
NADH
The cation of acids; consists of a hydrogen atom whose electron has been transferred t the anion of the acid.
Hydrogen ion
Co-enzyme of dehydrogenases; plays a role in intermediary metabolism as an oxidizing agent or reducing agent for metabolites.
NAD+
An organic byproduct of anaerobic metabolism derived from pyruvic acid; can be used as an energy source for cells.
Lactic acid
The phosphorylation of ATP coupled to the electron transport system
Oxidative phosphorylation
An acidic environment created when the pH level of muscle cells falls below 7
Muscle acidity
A major metabolic pathway that involves a series of enzymatic reactions that convert pyruvic acid from food to acetyl-CoA for energy
Krebs cycle
Set of compounds that transfers electrons to a donor that creates energy
Electron transport chain
Co-enzyme that plays a role in intermediary metabolism; can enter the Krebs cycle to produce energy and be used for fatty acids synthesis.
Acetyl-CoA
Breakdown of fatty acids that takes place in the mitochondria and peroxisomes
Beta oxidation
Riboflavin-derived hydrogen acceptor in the Krebs cycle
FAD+
The reduced form of FAD+
FADH2
Protein found in mitochondria (inner membrane) that transports electrons
Cytochrome
PArticle with a positive charge, usually regraded as a hydrogen ion; when the proton gradient shifts int eh electron transport chain, energy conversion occurs.
Proton
Synthesis of glycogen
Glycogenesis
Phosphorylated form of glucose that won’t diffuse out of a cell
Glucose 6-Phosphate
Enzyme necessary for the conversion of excess glucose into stored glycogen.
Glycogen synthase
Hormone and neurotransmitter; also know as adrenaline
Epinephrine
Hormone and neurotransmitter; also known as noradrenaline
Norepinephrine
Enzyme necessary for glycogenolysis; breaks glycogen into glucose units
Glycogen phosphorylase
Breakdown of stored glycogen to glucose
Glycogenolysis
Hormone secreted by the pancreas to increase blood glucose levels.
Glucagon
Endocrine cells of the pancreas that secrete glucagon
a-cells
Central part of the adrenal gland that secretes epinephrine, Norepinephrine and dopamine
Adrenal medulla
Series of reactions in the cytosol that converts glucose into pyruvic acid and ultimately ATP
Glycolysis
The point at which lactic acid begins to accumulate in the bloodstream
Anaerobic threshold
Intermediate that couples with acetyl-CoA to form citrate
Oxaloacetate
A higher capacity to oxidize fat
Fat adaptation
Liquid component of blood that suspends blood cells; contains water, glucose, proteins ad hormones
Plasma
Conversion of non-carbohydrate compounds (i.e., amino acids, pyruvate, glycerol) to glucose.
Gluconeogenesis
Use of lactate produced in the muscles by the liver for the production of glucose.
Cori cycle
fat tissue
Adipose tissue
Breakdown of triglycerides into fatty acids and glycerol
Lipolysis
Enzyme of the cytosol that frees fatty acids and glycerol
Hormone sensitive lipase
Using lipids as a fuel source
Lipid mobilization
Anabolic hormone that causes growth and cel reproduction; also known as somatotropin
Growth hormone
With oxygen present
Aerobic
Without oxygen present
Anaerobic
A glycerol with one fatty acid chain
Monoglyceride
A glycerol with two fatty acid chains
Diglyceride
System of enzymes involved int eh synthesis of fatty acids
Fatty acid synthase system
Addition of carbons on a fatty acid chain
Elongation
A fatty acid with no double bonds in the chain
Saturated fatty acid
Removal of hydrogen atoms to form a double bond
Desaturation
A single double bond in the fatty acid chain
Monounsaturated fatty acid
Particles used in lipid transport; assembled in the liver by cholesterol ad apolipoproteins, converted to LDL.
Very low density lipoprotein particles (VLDL)
Enzyme involved with the synthesis of fat
Lipogenic enzyme
Unsaturated omega-3 fatty acid
Alpha linolenic acid (ALA)
Family of unsaturated fatty acids characterized by a carbon-carbon double bond three spaces in from the methyl end
Omega-3
Unsaturated omega-6 fatty acid considered essential to the human diet
Linoleic acid
Family of unsaturated fatty acids characterized by a carbon-carbon double bond six spaces in from the methyl end
Omega-6
A fatty acid with multiple double bonds in the chain
Polyunsaturated fatty acid
A lipoprotein that transports cholesterol and triglyceride from the small intestines to tissues of the body
Chylomicron
A class of proteins with hydrophobic core of triglycerides or cholesterol surrounded by hydrophilic phospholipids, apolipoproteins and cholesterol
Lipoprotein
Lipid/sterol contained in the body’s cells and fluids that acts as a precursor to hormones and bodily structures
Cholesterol
Pharmaceutical agents that decrease cholesterol production within the body via down regulation of HMG-CoA redutase
Statin drugs
Lipid binding protein that is part of a lipoprotein
Apolipoprotein
A lipoprotein that transports triglyceride and cholesterol from the liver to body tissues
LDL cholesterol
A lipoprotein that transports fatty acids and cholesterol from the body tissues to the liver
HDL cholesterol
An enzyme that is used to convert cholesterol to a transportable form for lipoproteins
Lecithin-cholesterol acyltransferase (LCAT)
Development of plaque in the lumen (interior space) of blood vessels
Atherosclerosis