Chapter 3 Flashcards
What are the two basic divisions of the nervous system?
- Central nervous system (CNS)
- Peripheral nervous system (PNS)
Where is the central nervous system located?
- Brain
- Spinal cord
What does the central nervous system do?
Controls most functions of the body and mind
What are the two divisions of the peripheral nervous system?
- Somatic nervous system
- Autonomic nervous system
What does the somatic aspect of the peripheral nervous system control?
- Controls voluntary muscles
- Conveys sensory information to CNS
- Interacts with the external environment
What does the afferent nerves of the somatic aspect of the peripheral nervous system do?
- Carry sensory signals from the skin, skeletal muscles, joints, eyes, ears, etc., to the CNS
- Going towards the CNS; arrive
What does the efferent nerves of the somatic aspect of the peripheral nervous system do?
- Carry motor signals from the CNS to the skeletal muscles
- Going away from the CNS; exit
What does the autonomic aspect of the peripheral nervous system control?
- Controls involuntary muscles
- Fight or flight (sympathetic)
- Rest and digest (parasympathetic)
What is an example of an autonomic aspect of the peripheral nervous system function?
Regulating the body’s internal environment
What does the efferent nerves of the autonomic aspect of the peripheral nervous system do?
- Carry motor signals from the CNS to internal organs
- Two types: Sympathetic/parasympathetic
What does the sympathetic efferent nerves of the autonomic aspect of the peripheral nervous system do?
- Fight or flight
- Energy expanding
- Fires less since you aren’t in a constant state of fear/nervousness
What does the parasympathetic efferent nerves of the autonomic aspect of the peripheral nervous system do?
- Rest and digest
- Energy conserving
- Fires more since you aren’t in a constant state of fear/nervousness
What does the afferent nerves of the autonomic aspect of the peripheral nervous system do?
Carry sensory signals from internal organs to the CNS
Which nervous system is more protected than the other?
Central nervous system
What makes the CNS better protected than the PNS?
- Mechanical protection: Skull and meninges (dura mater, arachnoid, pia mater layers), vertebrae, cerebrospinal fluid (buffer/shock absorber)
- Immunological protection: Blood-brain barrier
Which nervous system can regenerate while the other cannot?
The peripheral nervous system can
How does the PNS regenerate itself?
- Schwann cells form lines and reconnect
- Axons regrow as long as the soma is intact
What is the blood brain barrier (BBB), physically?
A highly selective permeable border made of tightly packed cells
What purpose does the blood brain barrier (BBB) serve?
Protects the brain from circulating pathogens
Dorsal (posterior)
Toward or at the back of the body
Ventral (anterior)
Toward or at the front of the body
Lateral
Away from the midline of the body
Medial
Toward or at the midline of the body
Caudal (inferior)
Away from the head or toward the lower part of a structure or the body (below)
Rostral
Towards the nose/beak
Major parts of a neuron
- Cell membrane
- Cell body
- Dendrites
- Axon hillock
- Axon
- Myelin
- Nodes of Ranvier
- Buttons
- Synapses
Cell membrane
Cell body
The semipermeable membrane that encloses the neuron `
The metabolic center of the neuron; also called the soma
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Dendrites
The short processes emanating from the cell body, which receive most of the synaptic contacts from other neuronshttps://quizlet.com/cdn-cgi/image/f=auto,fit=cover,h=200,onerror=redirect,w=240/https://o.quizlet.com/7PAjP4araS-vTd2JMISgpA.png
Axon hillock
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The cone-shaped region at the junction between the axon and the cell body
Axon
The long, narrow process that projects from the cell body
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Myelin
The fatty insulation around many axons
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Nodes of Ranvier
The gaps between sections of myelin
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Buttons
The button-like endings of the axon branches, which release chemicals into synapses
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Synapses
The gaps between adjacent neurons across which chemical signals are transmitted
What are the major types of proteins that are embedded in a neuron’s lipid bilayer membrane?
- Ion channels
- Receptors
- Transporters
What is the role of an ion channel that is embedded in a neuron’s lipid bilayer membrane?
Regulate cation + / cation - flow in/out of cell
What is the role of a receptor that is embedded in a neuron’s lipid bilayer membrane?
- Neurotransmitters bind to them
- Signal excitation (+, increase firing)
- Signal inhibition (-, decrease firing)
What is the role of transporters that are embedded in a neuron’s lipid bilayer membrane?
- Actively move important molecules in/out of the cell
- Ex. Na+ / K+ transporter
Major cations involved with learning/memory and neurotransmitter release
- Na+
- Ca+
- K+
- Mg+
Major anion involved with learning/memory and neurotransmitter release
Cl-
What are the 3 glial cells in the CNS
- Oligodendrocytes
- Microglia
- Astrocytes
Oligodendrocytes
- Glial cell in the CNS
- Produce myelin sheath
Microglia
- Glial cell in the CNS
- Respond to injury/disease
- Clean up: Trigger inflammation, regulate synapse formation and elimination
Astrocytes
- Glial cell in the CNS
- Contribute to the blood brain barrier, regulate blood flow
What glial cell is in the PNS
Schwann cells
Schwann cells
- Glial cell in PNS
- Produces the myelin sheath and results in direct axonal regrowth after injury
What are the 3 major divisions of the brain?
- Hindbrain
- Midbrain
- Forebrain
What is located in the hindbrain?
- Medulla
- Pons
- Cerebellum
- C on picture
the lower bottom bulb
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What is the main function of the hindbrain?
Handles the primitive parts without you realizing it
Medulla
- Part of the hindbrain
- Autonomic
- Basic life support functions (breathing, heartbeat, digestion, swallow/cough/vomit)
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When people OD on opioids it makes it hard for the body to function normally and care for itself. Where do the opioids bind to the neurons?
Medulla
Pons
- Soma of “reticular activating” neurons
- Responsible for wakefulness (Raphe) /alertness (Locus Coeruleus)
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Locus coeruleus
- Used in the pons
- Keeps individuals alert
- Norepinephrine releasing
Raphe
- Used in the pons
- Sleep/wake cycle
- 5-HT-releasing
A drug that induces (heightens) the levels of locus coeruleus and raphe in the pons would result in:
Insomnia
Cerebellum
- Part of the hindbrain
- Motor coordination/balance (execution of learned motor sequences, largely unconscious during execution)
- Practice develops circuitry in the cerebellum
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What could result from a tiny stroke in the cerebellum?
- Loss of coordination for well known movements
- An individual losing the ability to stand/walk correctly
E.B. has a tumor growing in his brain. Although he has been an excellent salsa dancer for many years, he is having more and more trouble getting the timing and sequence (pattern) of the steps right. Where is the tumor most likely to
be located?
Cerebellum
What 3 nuclei are located in the midbrain?
- Periaqueductal gray (PAG)
- Ventral tegmental area (VTA)
- Substantia nigra
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Superior colliculus
- Part of the midbrain/tectum
- Visual coordination of movement
- When you see something odd it makes you want to look at it
Inferior colliculus
- Part of the midbrain/tectum
- Sound localization; auditory coordination of movement
- When you hear a loud boom it will make you look
Periaqueductal gray (PAG)
- Part of the midbrain/tegmentum
- Pain modulation/control area of the brain
- Opioids bind here and disinhibit it
Ventral tegmental area (VTA)
- Part of the midbrain/tegmentum
- Pleasure/motivated behavior
- Major dopamine creating/releasing
Someone who doesn’t want to do anything and experiences little enjoyment most likely has something wrong with their:
Ventral tegmental area (VTA)
Substantia nigra
- Part of the midbrain/tegmentum
- Speed of movement
- Dopamine releasing
What neuron does Parkinson’s disease affect?
Substantia nigra
What is located in the forebrain?
- Thalamus
- Hypothalamus
- Basal ganglia
- Amygdala
- Hippocampus
- Cerebrum (4 lobes)
Thalamus
- Part of the forebrain
- Sensory motor “relay/coordinating station”
- Wanting to move right big toe
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What can damage to the thalamus result in?
- Movement disorders
- Lack of movement
Hypothalamus
- Part of the forebrain
- 4F’s: Feeding, fornication, fight, flight
- Sympathetic nervous system activation starts here
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What can damage to the hypothalamus result in?
Disruptions in body temperature regulation, growth, weight, emotions
Basal ganglia
- Part of the forebrain
- Habitual movement
Examples of basal ganglia movements
- Swatting away a fly
- OCD
- Having a tick
Example of a hypothalamus function
Waking up hot (past normal time of waking up) and wanting to throw off blankets
What disease affects the basal ganglia?
- Huntington’s disease
- Uncontrolled movement caused by deterioration of this brain area
- Arms don’t stop moving, ultimately develop dementia
Amygdala
- Part of forebrain
- Emotions (particularly fear and anger)
What would damage to the amygdala cause?
Emotional sensitivity
L.C. has become increasingly aggressive over the past few months, often getting into fights after very little provocation. What part of L.C.’s brain may be malfunctioning?
Amygdala
Hippocampus
- Part of the forebrain
- Learning/memory
Example of damage to the hippocampus
- H.M.
- They took part of this brain area out and cured his epilepsy, but he was incapable of learning new things
P.D. recently started taking medication to control epilepsy. Unfortunately, she now finds that she really struggles with coursework; she is spending even more time studying but often has trouble remembering much of what she read the night before? The medication is probably impairing what part of P.D. ‘s brain?
Hippocampus
What are the 4 lobes of the cerebrum
- Occipital lobe
- Parietal lobe
- Temporal lobe
- Frontal lobe
Occipital lobe
- Part of the cerebrum/forebrain
- Simple visual perception
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Parietal lobe
- Part of the cerebrum/forebrain
- Somatosensory perception (anterior)
- Complex visual perception (posterior)
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Temporal lobe
- Part of the cerebrum/forebrain
- Complex visual perception
- Auditory perception
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Frontal lobe
- Part of the cerebrum/forebrain
- Decision making/reasoning: Prefrontal cortex (anterior)
- Planning/control on conscious movement: Motor cortex (posterior)
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What does the prefrontal cortex of the frontal lobe do?
Decision making/reasoning
What does the motor cortex of the frontal lobe do?
Planning/control on conscious movement
What might damage to the cerebrum result in?
- Personality disorders
- Loss of senses
S.L. & E.G. each swallow a pill. A half hour later a friend asks them if they want to go to College Hill party, a movie, or stay home. They simply cannot make a decision; they’re having trouble holding all options in mind at the same time. What part of their brains have probably been affected by the pill?
Prefrontal cortex
Homunculus arrangement
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Motor and sensory systems are said to be mostly “crossed over” - what does this mean?
- Primary motor cortex axons → crossover at medulla → controls muscles on the other side of the body
- Somatosensory neurons on one side of body axons → crossover in spinal cord → ascent to thalamus, somatosensory cortex on the other side of the brain
What neurons almost completely crossover to the other side of the brain?
- Visual neurons
- Auditory neurons
If a stroke affects the left side of the body, then the stroke most likely occurred on the __ hemisphere of the brain
Right
The ________ nervous system is composed of the brain and the spinal cord.
central
Twelve pairs of ________________ project from the brain.
cranial nerves
________ nerves stimulate, organize, and mobilize energy resources in threatening situations.
Sympathetic
________ is continuously produced by the choroid plexuses.
Cerebrospinal fluid
The ________ blocks the entry of many large molecules into brain tissue from the circulatory system.
blood–brain barrier