Chapter 3 Flashcards
How many neurons are in the brain?
85-100 billion
How many synapses per neuron?
Around 1000
What are the 3 parts of a neuron and their purpose?
- Dendrite
- receives messages form other neurons - Cell Body
- processes all incoming signals from dendrites
- can receive signals directly as well
- contains the vital cell structures (nucleus, DNA) - Axon
- sends OUT signals to other neurons, muscles or glands
What is the concentration at resting potential?
More Na+ outside the cell, more K+ inside the cell at resting potential
What are the 5 steps in an action potential and parts of each step?
- Resting Potential
- Depolarization
- Na+ flooding into the cell causing the charge to become positive relative to the outside of the cell - Repolarization
- the sodium potassium pumps are at work because the Na+ and K+ are on the wrong side of the cell membrane at this point - Hyper-polarization
- the cell becomes more negative than it needs to
- overshoot - Resting Potential
What is a graded potential?
An electrical pulse that does not meet threshold, therefore an action potential does not fire.
Many graded potentials can be added together to reach the threshold.
Glial Cells 4
Made to take care of the neuron
- keep them in place
- manufacture needed nutrients
- absorb toxins and waste
- in development, helps convey them to the right place
(HOLD THEM, FEED THEM, PROTECT THEM, GUIDE THEM)
also produces some myelin
Myelin 5
- fatty layer pf insulation surrounding an axon
- makes sending signals much faster
- more like a string of beads
- the breaks in between are called Nodes of Ranvier
- not all neurons have a myelin sheath
- some Glial cells produce myelin
Damage to myelin causes?
Multiple sclerosis
- brain and spinal problems
- vision, balance, arm or leg movement problems
- lifelong condition
What is a neurotransmitter?
A chemical substance that helps neurons communicate with each other
5 steps of chemical communication across the synapse
- Synthesize
- neurons make the NT - Storage
- store NT in synaptic vesicles - Release
- when action potential reaches axon terminals of presynaptic neuron, vesicles pop - Binding
- molecules of NT attach to special receptors on the postsynaptic neuron - Deactivation
- receptors and NT are pulled apart, ending the signal
Excitation NT
some NT make the postsynaptic neuron more likely to fire
- binding with receptor site causes some Na+ to enter the postsynaptic neuron
- If enough excitation an action potential will fire
Inhabitation NT
some NT make postsynaptic neuron less likely to fire
- makes inside even more negative
- even harder to reach threshold
Name the 7 Neurotransmitters
- Glutamate
- Acetylcholine
- Serotonin
- Dopamine
- GABA
- Endorphins
- Norepinephrine
Glutamate
- excitatory
- learning and memory
- too much=seizures, neuron death
Acetylcholine
- excitatory
- muscle movement and memory
- too little= Alzheimer’s disease, paralysis
- too much= convulsions
Dopamine
- excitatory and inhibitory
- reward, pleasure, voluntary motor control, control of thought
- too little= parkisons disease
- too much = schizophrenia
GABA
- inhibitory
- motor control, lowering anxiety
- too much=limits brain function (drunk)
- too little= tremors, lose motor control, anxiety
Serotonin
- inhibitory
- mood, pleasure
- too little= depression and or anxiety
Endorphins
- inhibitory
- inhibiting pain
- too little= hypersensitivity to pain
- too much= insensitivity to pain
Norepinphrine
- excitatory
- adrenaline, stress hormone
- vigilance and awakeness
- too little= depression, anxiety
- too much= anxiety
Agonist drugs 3
- increase activity of a NT
- synthesizes, stores and releases more
- can directly activate receptor site or slow down and stop deactivation
Antagonist drugs 3
- decrease activity of a NT
- synthesized, releases, stores less
- or binds to receptor without activating it (blocking it)
4 types of methods for studying the brain & description
- destruction and stimulation
- ablation: removing a portion of the brain (animal)
- lesions: focused damage on a specific part of the brain (humans) usually using tiny electrodes
- stimulation: using tiny electrodes to hit a single neuron
Stimulation discovered Localization of Function (specific cognitive functions are served by specific areas of the brain) - neurological testing
- testing verbal and non verbal behaviours known to be affected by brain damage
- typically used in clinical settings - electrical reading
- use of electrodes to measure the electrical activity in the brain
- EEG hair net to map out/ measure activity - Brain imaging
- computerized PET, CAT xrays
- fMRI
PET scans
measure using radioactive glucose injections.