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Patho > Chapter 26 > Flashcards

Chapter 26 Flashcards

1
Q

Aneurysmal bone cyst mostly develop in the following, except:

a. femur
b. tibia
c. flat bones of the pelvis
d. vertebral body posterior elements

A

C

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2
Q

In 70% of the cases of aneurysmal bone cyst, chromosome 17p13 are present in which of the following?

a. plump spindle cells
b. multinucleated giant cells
c. inflammatory cells
d. endothelial cells

A

A

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3
Q

ABCs consist of multiple blood-filled cystic spaces separated by thin, tan-white septa. The septa are composed of the following except:

a. plump spindle cells
b. multinucleated giant cells
c. reactive woven bone lined by osteoblasts
d. endothelial cells

A

D

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4
Q

The following are true about fibrous cortical defects, except:

a. fibrous cortical defects is also known as metaphyseal fibrous defect
b. fibrous connective tissue replaces bone
c. lesions are present in up to 50% of children younger than 2
d. present as incidental finding in adolescents

A

C

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5
Q

Patterns present in McCune-Albright syndrome include the following, except:

a. polyostotic disease
b. endocrine abnormalities
c. precocious puberty
d. soft tissue myxomas

A

D

mazabraud syndrome: fibrous dysplasia (polycystic) and soft tissue myxomas

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6
Q

Which of the following is produced when the mutation in GNAS1 that occurs in early embryogenesis?

a. McCune-Albright syndrome
b. Mazabraud syndrome
c. monostotic fibrous dysplasia
d. polystotic fibrous dysplasia

A

A

monostotic fibrous dysplasia - mutation in osteoblast precursor during or after formation of the skeleton

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7
Q

The following are the most commonly affected by monostotic fibrous dysplasia, except:

a. femur
b. pelvic
c. tibia
d. calvarium

A

B

+ jawbones and ribs

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8
Q

The following are the most frequently affected by polyostotic fibrous dysplasia, except:

a. femur
b. skull
c. tibia
d. calvarium

A

D

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9
Q

The following are the pathways of spread of metastatic tumors, except:

a. direct extension
b. lymphatic spread
c. hematogenous spread
d. intraspinal seeding
e. none of the options

A

E

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10
Q

The following produce lytic lesions, except:

a. carcinoma of the kidney
b. adenocarcinoma
c. carcinoma of the lung
d. malignant melanoma

A

B

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11
Q

The following are the characteristics of of solid joints or synarthroses, except:

a. situated b/w the ends of bones formed via endochondral ossification
b. provide structural integrity
c. lack a joint space
d. only minimal movement

A

A

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12
Q

Fibrous synarthroses include the following, except:

a. cranial sutures
b. pubic symphyses
c. bonds between roots teeth and jawbones
d. none of the options

A

B

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13
Q

Hyaline cartilage is composed of the following, except:

a. water
b. type I collagen
c. proteoglycans
d. chondrocytes

A

B

carTWOlage

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14
Q

It is the most common types of joint disease

a. osteoarthritis
b. rheumatoid arthritis
c. reactive arthritis
d. mycobacterial artritis

A

A

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15
Q

The joints that are commonly involved in OA include the following, except:

a. hips
b. knees
c. shoulders
d. first tarsometatarsal joints

A

C

spared: wrists, elbows, shoulders

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16
Q

The following are true about RA except:

a. three times more common in women
b. ankylosis is present
c. produces inflammatory synovitis
d. joints involved are the primary weight bearing joints

A

D

17
Q

The following are cytokine mediators involved in RA, which is not correctly paired to its function?

a. IFN-gamma: activates macrophages and resident synovial cells
b. IL-17: recruits eosinophils and monocytes
c. RANKL: stimulates bone resorption
d. TNF and IL-1: stimulate synovial cells to secrete proteases and destroy hyaline cartilage

A

B

should be neutrophils

18
Q

These are diagnostic markers that can be detected in serum of up to 70% of px with RA

a. citrullinated peptieds
b. rheumatoid factor
c. anti-citrullinated peptide antibodies
d. vinculin

A

C

19
Q

Features of seronegative spondyloarthropathies include the following, except:

a. absence of rheumatoid factor
b. pathologic changes in the ligamentous attachements
c. sacroiliac joint is spared
d. association with HLA-B27
e. bony proliferation leading to ankylosis

A

C

20
Q

Reactive arthritis is defined as the triad of the following, except:

a. arthritis
b. cervicitis
c. conjunctivitis
d. gonococcal urethritis

A

D

21
Q

It causes suppurative arthritis in children younger than 2 years old

a. H. influenzae
b. S. aureus
c. M. tuberculosis
d. EBV

A

A

older children and adults - S. aureus

22
Q

It is caused by the spirochete Borrelia burdorferri, which is transmitted by deer ticks

a. suppurative arthritis
b. mycobacterial arthritis
c. viral arthritis
d. lyme arthritis

A

D

23
Q

Endogenous crystals involved in crystal-induced arthritis, except:

a. monosodium urate
b. calcium pyrophosphate
c. basic calcium phosphate
d. none of the options

A

D

24
Q

Characterized by synovium that becomes hyperplastic, fibrotic, and thickened by inflammatory cells

a. acute arthritis
b. chronic tophaceous arthjritis
c. Lesch-Nyhan syndrome
d. urate nephropathy

A

B

25
Q

It is the pathognomonic hallmark of gout

a. tophi
b. monosodium urate crystlas
c. swan-neck deformity
d. boutonniere

A

A

26
Q

Cyst that is up to 1.5 cm, nearly always located near a joint capsule or tendon sheath

a. ganglion cysts
b. synovial cysts
c. hyaline cysts
d. tenosynovial giant cell tumor

A

A

27
Q

It is the most common soft tissue tumor in adults

a. lipoma
b. liposarcoma
c. nodular fasciitis
d. fibromatoses

A

A

28
Q

Characteristics of liposarcoma, except:

a. well-differentiated
b. myxoid
c. benign tumor of fat
d. pleomorphic

A

C

29
Q

It is a self-limited fibroblastic proliferation in young adults

a. nodular fasciitis
b. superficial fibromatosis
c. deep fbromatosis
d. none of the options

A

A

30
Q

Most common soft tissue sarcoma of childhood and adolescence

a. Ewing sarcoma
b. Rhabdomyosarcoma
c. Synovial sarcoma
d. Undifferentiated pleomorphic sarcoma

A

B

31
Q

Most common neoplasm in women

a. lipoma
b. liposarcoma
c. leiomyoma
c. leiomyosarcoma

A

C

32
Q

Palpable induration or mass on the dorsolateral aspect of the penis

a. Palmar fibromatosis
b. Plantar fibromatosis
c. Peyronie disease
d. Ledderhose disease
e. Dupuyten contracture

A

C

Palmar fibromatosis - irregular or nodular thickening of palmar fascia (Dupyten)
Plantar fibromatosis - boys under 10, unilateral assoc with palmar and penile fibromatosis (Ledderhose)

Patho (13 decks)

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