Chapter 26 Flashcards
Aneurysmal bone cyst mostly develop in the following, except:
a. femur
b. tibia
c. flat bones of the pelvis
d. vertebral body posterior elements
C
In 70% of the cases of aneurysmal bone cyst, chromosome 17p13 are present in which of the following?
a. plump spindle cells
b. multinucleated giant cells
c. inflammatory cells
d. endothelial cells
A
ABCs consist of multiple blood-filled cystic spaces separated by thin, tan-white septa. The septa are composed of the following except:
a. plump spindle cells
b. multinucleated giant cells
c. reactive woven bone lined by osteoblasts
d. endothelial cells
D
The following are true about fibrous cortical defects, except:
a. fibrous cortical defects is also known as metaphyseal fibrous defect
b. fibrous connective tissue replaces bone
c. lesions are present in up to 50% of children younger than 2
d. present as incidental finding in adolescents
C
Patterns present in McCune-Albright syndrome include the following, except:
a. polyostotic disease
b. endocrine abnormalities
c. precocious puberty
d. soft tissue myxomas
D
mazabraud syndrome: fibrous dysplasia (polycystic) and soft tissue myxomas
Which of the following is produced when the mutation in GNAS1 that occurs in early embryogenesis?
a. McCune-Albright syndrome
b. Mazabraud syndrome
c. monostotic fibrous dysplasia
d. polystotic fibrous dysplasia
A
monostotic fibrous dysplasia - mutation in osteoblast precursor during or after formation of the skeleton
The following are the most commonly affected by monostotic fibrous dysplasia, except:
a. femur
b. pelvic
c. tibia
d. calvarium
B
+ jawbones and ribs
The following are the most frequently affected by polyostotic fibrous dysplasia, except:
a. femur
b. skull
c. tibia
d. calvarium
D
The following are the pathways of spread of metastatic tumors, except:
a. direct extension
b. lymphatic spread
c. hematogenous spread
d. intraspinal seeding
e. none of the options
E
The following produce lytic lesions, except:
a. carcinoma of the kidney
b. adenocarcinoma
c. carcinoma of the lung
d. malignant melanoma
B
The following are the characteristics of of solid joints or synarthroses, except:
a. situated b/w the ends of bones formed via endochondral ossification
b. provide structural integrity
c. lack a joint space
d. only minimal movement
A
Fibrous synarthroses include the following, except:
a. cranial sutures
b. pubic symphyses
c. bonds between roots teeth and jawbones
d. none of the options
B
Hyaline cartilage is composed of the following, except:
a. water
b. type I collagen
c. proteoglycans
d. chondrocytes
B
carTWOlage
It is the most common types of joint disease
a. osteoarthritis
b. rheumatoid arthritis
c. reactive arthritis
d. mycobacterial artritis
A
The joints that are commonly involved in OA include the following, except:
a. hips
b. knees
c. shoulders
d. first tarsometatarsal joints
C
spared: wrists, elbows, shoulders
The following are true about RA except:
a. three times more common in women
b. ankylosis is present
c. produces inflammatory synovitis
d. joints involved are the primary weight bearing joints
D
The following are cytokine mediators involved in RA, which is not correctly paired to its function?
a. IFN-gamma: activates macrophages and resident synovial cells
b. IL-17: recruits eosinophils and monocytes
c. RANKL: stimulates bone resorption
d. TNF and IL-1: stimulate synovial cells to secrete proteases and destroy hyaline cartilage
B
should be neutrophils
These are diagnostic markers that can be detected in serum of up to 70% of px with RA
a. citrullinated peptieds
b. rheumatoid factor
c. anti-citrullinated peptide antibodies
d. vinculin
C
Features of seronegative spondyloarthropathies include the following, except:
a. absence of rheumatoid factor
b. pathologic changes in the ligamentous attachements
c. sacroiliac joint is spared
d. association with HLA-B27
e. bony proliferation leading to ankylosis
C
Reactive arthritis is defined as the triad of the following, except:
a. arthritis
b. cervicitis
c. conjunctivitis
d. gonococcal urethritis
D
It causes suppurative arthritis in children younger than 2 years old
a. H. influenzae
b. S. aureus
c. M. tuberculosis
d. EBV
A
older children and adults - S. aureus
It is caused by the spirochete Borrelia burdorferri, which is transmitted by deer ticks
a. suppurative arthritis
b. mycobacterial arthritis
c. viral arthritis
d. lyme arthritis
D
Endogenous crystals involved in crystal-induced arthritis, except:
a. monosodium urate
b. calcium pyrophosphate
c. basic calcium phosphate
d. none of the options
D
Characterized by synovium that becomes hyperplastic, fibrotic, and thickened by inflammatory cells
a. acute arthritis
b. chronic tophaceous arthjritis
c. Lesch-Nyhan syndrome
d. urate nephropathy
B
It is the pathognomonic hallmark of gout
a. tophi
b. monosodium urate crystlas
c. swan-neck deformity
d. boutonniere
A
Cyst that is up to 1.5 cm, nearly always located near a joint capsule or tendon sheath
a. ganglion cysts
b. synovial cysts
c. hyaline cysts
d. tenosynovial giant cell tumor
A
It is the most common soft tissue tumor in adults
a. lipoma
b. liposarcoma
c. nodular fasciitis
d. fibromatoses
A
Characteristics of liposarcoma, except:
a. well-differentiated
b. myxoid
c. benign tumor of fat
d. pleomorphic
C
It is a self-limited fibroblastic proliferation in young adults
a. nodular fasciitis
b. superficial fibromatosis
c. deep fbromatosis
d. none of the options
A
Most common soft tissue sarcoma of childhood and adolescence
a. Ewing sarcoma
b. Rhabdomyosarcoma
c. Synovial sarcoma
d. Undifferentiated pleomorphic sarcoma
B
Most common neoplasm in women
a. lipoma
b. liposarcoma
c. leiomyoma
c. leiomyosarcoma
C
Palpable induration or mass on the dorsolateral aspect of the penis
a. Palmar fibromatosis
b. Plantar fibromatosis
c. Peyronie disease
d. Ledderhose disease
e. Dupuyten contracture
C
Palmar fibromatosis - irregular or nodular thickening of palmar fascia (Dupyten)
Plantar fibromatosis - boys under 10, unilateral assoc with palmar and penile fibromatosis (Ledderhose)
