Chapter 23 Flashcards
It may occasionally produce a vague nodularity, detected as clustered or linear and branching areas of calcification
a. comedo DCIS
b. cribriform DCIS
c. micropapillary DCIS
d. papillary DCIS
A
Defined by tumor cells with pleomorphic, high-grade nuclei and areas of central necorsis
a. comedo DCIS
b. cribriform DCIS
c. micropapillary DCIS
d. papillary DCIS
A
Has cookie cutter-like space that is often filled with calcified secretory material
a. comedo DCIS
b. cribriform DCIS
c. micropapillary DCIS
d. papillary DCIS
B
micropapillary DCIS - produces complex protrusions without fibrovascular cores
papillary DCIS - produces true papillae with fibrovascular cores that lack a myoepithelial cell layer
Presents as a unilateral erythematous eruption with a scale crust
a. Paget disease
b. lobular carcinoma in situ
c. ductal carcinoma in situ
d. invasive carcinoma
A
It is associated with defects in DNA repair or genomic stability
a. HER2 cancers
b. luminal cancers
c. TNBC
d. DCIS
C
Major risk factors for recurrence of DCIS include the following, except:
a. high nuclear grade and necrosis
b. extent of disease
c. positive surgical margins
d. hard irregular radiodense masses
D
Using the Nottingham Histologic Score, Grade I carcinoma is described as the following, except:
a. well differentiated
b. have a low proliferative rate
c. grow in a tubular or cribriform pattern
d. have a small differentiated nuclei
D
Using the Nottingham Histologic Score, carcinomas that have areas where cells grow as solid clusters or single infiltrating cells and show greater nuclear pleomorphism and high number of mitotic figures is graded as:
a. Grade I
b. Grade II
c. Grade III
d. Grade IV
B
Grade I - well differentiated
Grade II - moderately differentiated
Grade III - poorly differentiated; invade as ragged nests or solid sheets of cells and have enlarged irregular nuclei
Subtype with the clearest association of phenotype and genotype
a. lobular carcinoma
b. mucnous carcinoma
c. tubular carcinoma
d. papillary carcinoma
A
These are dyscohesive, typically infiltrate single cells, and sometimes fail to produce a desmoplastic response
a. lobular carcinoma
b. mucnous carcinoma
c. tubular carcinoma
d. papillary carcinoma
e. medullary carcinoma
A
These have unusually large number of infiltrating T lymphocytes
a. lobular carcinoma
b. mucnous carcinoma
c. tubular carcinoma
d. papillary carcinoma
e. medullary carcinoma
E
It is soft or rubbery and has the appearance and consistency of pale gray-blue gelatin
a. lobular carcinoma
b. mucnous carcinoma
c. tubular carcinoma
d. papillary carcinoma
e. medullary carcinoma
B
+ arranged in clusters and small islands within large lakes of mucin
It is sometimes mistaken for a benign sclerosing lesion
a. lobular carcinoma
b. mucnous carcinoma
c. tubular carcinoma
d. papillary carcinoma
e. medullary carcinoma
C
Which of the following is incorrectly matched?
a. apocrine carcinoma: resemble sweat glands
b. micropapillary carcinoma: mimic the appearance of true papillae
c. metaplastic carcinoma: resemble myoepithelial cells
d. secretory carcinoma: mimics the surface of an orange peel
D
secretory: mimics lactating breast
inflammatory: mimics surface of an orange peel; peau d’orange
Most important prognostic factor
a. nodal metastasis
b. distant metastasis
c. tumor size
d. histologic grade
B
