Chapter 23: Direct Renin Inhibitors

Question 1

Drug:

Answer 1

Aliskiren (Tekturna)

Question 2

Actions:

Answer 2

1. Blocks the first step in the RAAS cascade

2. Preventing release of aldosterone

Question 3

Uses:

Answer 3

1. Alone or in combination with other antihypertensives to reduce BP
2. Not as effective in African Americans, older adults
3. Reserved for patients who do not respond to ACE inhibitors or ARBs

Question 4

CAE’s

Answer 4

1. Dyspepsia
2. Cramps
3. Diarrhea
4. Headache
5. Orthostatic hypotension

Question 5

SAE’s

Answer 5

1. Altered fluid and electrolytes

2. Birth defects