Chapter 23: Aldosterone Receptor Antagonist

Question 1

Drug:

Answer 1

Eplerenone (Inspra)

Question 2

Actions:

Answer 2

1. Block stimulation of aldosterone at receptor sites

2. Prevent sodium reabsorption

Question 3

Uses:

Answer 3

1. Alone
2. In combination with other hypertensives to reduce BP
3. Treat heart failure

Question 4

CAE’s:

Answer 4

1. Nausea
2. Diarrhea
3. Fatigue
4. Headache
5. Orthostatic hypotension

Question 5

SAE’s

Answer 5

1. Hyperkalemia
2. Elevated lipids
3. Nephrotoxicity
4. Hepatotoxicity
5. Gynecomastia
6. Vaginal bleeding
7. Numerous drug interactions
8. Lower dose required for older adults, those with hepatic failure